The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation
Kulkarni S, Stephenson R, Amalraj S, Arrigo A, Betleja E, Moresco J, Yates J, Mahjoub M, Miller A, Khokha M. The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation. Cytoskeleton 2024 PMID: 39479942, DOI: 10.1002/cm.21952.Peer-Reviewed Original ResearchRhoA regulationCytokinetic contractile ringLeft-right organizerLR patterningRhoA protein levelsContractile ringGTPase RhoADepletion phenotypeMonociliated cellsCCDC11Loss of functionCytokinesisRhoAPatient phenotypesPhenotypeDisease pathogenesisProtein levelsMultiple ciliaCellsPotential mechanismsRegulationGTPaseCFAP53MulticiliationMutations