2022
Safety and Glycemic Outcomes With a Tubeless Automated Insulin Delivery System in Very Young Children With Type 1 Diabetes: A Single-Arm Multicenter Clinical Trial
Sherr JL, Bode BW, Forlenza GP, Laffel LM, Schoelwer MJ, Buckingham BA, Criego AB, DeSalvo DJ, MacLeish SA, Hansen DW, Ly TT, Sherr J, Weyman K, Tichy E, VanName M, Brei M, Zgorski M, Steffen A, Carria L, Bode B, Busby A, Forlenza G, Wadwa R, Slover R, Cobry E, Messer L, Laffel L, Isganaitis E, Ambler-Osborn L, Freiner E, Turcotte C, Volkening L, Schoelwer M, Brown S, Krauthause K, Emory E, Oliveri M, Buckingham B, Ekhlaspour L, Kingman R, Criego A, Schwartz B, Gandrud L, Grieme A, Hyatt J, DeSalvo D, McKay S, DeLaO K, Villegas C, MacLeish S, Wood J, Kaminski B, Casey T, Campbell W, Behm K, Adams R, Hansen D, Stone S, Bzdick S, Bulger J, Agostini L, Doolittle S, Kivilaid K, Kleve K, Ly T, Dumais B, Vienneau T, Huyett L, Lee J, O’Connor J, Benjamin E. Safety and Glycemic Outcomes With a Tubeless Automated Insulin Delivery System in Very Young Children With Type 1 Diabetes: A Single-Arm Multicenter Clinical Trial. Diabetes Care 2022, 45: 1907-1910. PMID: 35678724, PMCID: PMC9346983, DOI: 10.2337/dc21-2359.Peer-Reviewed Original ResearchConceptsInsulin delivery systemsSingle-arm studyLong-term complicationsMulticenter clinical trialType 1 diabetesSensor glucose levelsYoung childrenBaseline data collectionReduced hypoglycemiaDiabetic ketoacidosisGlycemic targetsUsual therapyGlycemic measuresSevere hypoglycemiaDelivery systemStudy endGlycemic outcomesClinical trialsGlucose levelsType 1HypoglycemiaInvestigational systemDlChildrenStudy phaseLong-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study
Van Name MA, Kanapka LG, DiMeglio LA, Miller KM, Albanese-O’Neill A, Commissariat P, Corathers SD, Harrington KR, Hilliard ME, Anderson BJ, Kelley JC, Laffel LM, MacLeish SA, Nathan BM, Tamborlane WV, Wadwa RP, Willi SM, Williams KM, Wintergerst KA, Woerner S, Wong JC, DeSalvo DJ. Long-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study. Journal Of Diabetes Science And Technology 2022, 17: 976-987. PMID: 35343269, PMCID: PMC10348002, DOI: 10.1177/19322968221084667.Peer-Reviewed Original ResearchMeSH KeywordsBlood GlucoseBlood Glucose Self-MonitoringChildChild, PreschoolDiabetes Mellitus, Type 1HumansHyperglycemiaHypoglycemiaConceptsFamily behavioral interventionsContinuous glucose monitoringBlood glucose monitoringCGM useYoung childrenGlucose monitoringOne-year resultsType 1 diabetesContinuous glucose monitor useHemoglobin A1cCGM groupGlycemic outcomesType 1Behavioral interventionsExtension phaseBGM groupMonitor useOne-year studyCGM technologyDiabetes technologyGlycemiaHypoglycemiaChildrenBehavioural supportGroup
2021
Continuous glucose monitoring use and glucose variability in very young children with type 1 diabetes (VibRate): A multinational prospective observational real‐world cohort study
Dovc K, Van Name M, Bizjan B, Rusak E, Piona C, Yesiltepe‐Mutlu G, Mentink R, Frontino G, Macedoni M, Ferreira SH, Serra‐Caetano J, Galhardo J, Pelicand J, Silvestri F, Sherr J, Chobot A, Biester T, Group F. Continuous glucose monitoring use and glucose variability in very young children with type 1 diabetes (VibRate): A multinational prospective observational real‐world cohort study. Diabetes Obesity And Metabolism 2021, 24: 564-569. PMID: 34820985, PMCID: PMC9306649, DOI: 10.1111/dom.14607.Peer-Reviewed Original Research
2020
Inequities in Diabetic Ketoacidosis Among Patients With Type 1 Diabetes and COVID-19: Data From 52 US Clinical Centers
Ebekozien O, Agarwal S, Noor N, Albanese-O’Neill A, Wong JC, Seeherunvong T, Sanchez J, DeSalvo D, Lyons SK, Majidi S, Wood JR, Acharya R, Aleppo G, Sumpter KM, Cymbaluk A, Shah NA, Van Name M, Cruz-Aviles L, Alonso GT, Gallagher MP, Sanda S, Feuer AJ, Cossen K, Rioles N, Jones NY, Kamboj MK, Hirsch IB. Inequities in Diabetic Ketoacidosis Among Patients With Type 1 Diabetes and COVID-19: Data From 52 US Clinical Centers. The Journal Of Clinical Endocrinology & Metabolism 2020, 106: 1755-1762. PMID: 33410917, PMCID: PMC7928931, DOI: 10.1210/clinem/dgaa920.Peer-Reviewed Original ResearchConceptsNH Black patientsLaboratory-confirmed COVID-19NH-White patientsDiabetic ketoacidosisType 1 diabetesNH blacksBlack patientsNH whitesWhite patientsHispanic patientsPotential confoundersLaboratory-confirmed coronavirus disease 2019COVID-19Multivariable logistic regression analysisUS clinical centersCross-sectional studyCOVID-19 infectionCoronavirus disease 2019Logistic regression analysisRace/ethnicity groupsMedian HbA1cSerious complicationsDKA eventsPatient factorsT1D patientsA Randomized Clinical Trial Assessing Continuous Glucose Monitoring (CGM) Use With Standardized Education With or Without a Family Behavioral Intervention Compared With Fingerstick Blood Glucose Monitoring in Very Young Children With Type 1 Diabetes.
Laffel L, Harrington K, Hanono A, Naik N, Ambler-Osborn L, Schultz A, DiMeglio L, Woerne S, Jolivette H, Ismail H, Tebbe M, Newman A, Legge M, Tamborlane W, Van Name M, Weyman K, Finnegan J, Steffen A, Zgorski M, DeSalvo D, Hilliard M, DeLaO K, Xie C, Levy W, Wadwa R, Forlenza G, Majidi S, Alonso G, Weber I, Clay M, Simmons E, Nathan B, Sunni M, Sweet J, Pappenfus B, Kogler A, Ludwig M, Nelson B, Street A, Weingartner D, Albanese-O’Neill A, Haller M, Adams J, Cintron M, Thomas N, Kelley J, Simmons J, William G, Brendle F, Goland R, Williams K, Gandica R, Pollak S, Casciano E, Robinson E, Willi S, Minnock P, Olivos D, Carchidi C, Grant B, Wong J, Adi S, Corathers S, Sheanon N, Fox C, Weis T, MacLeish S, Wood J, Casey T, Campbell W, McGuigan P, Wintergerst K, Watson S, Kingery S, Pierce G, Ruch H, Rayborn L, Rodriguez-Luna M, Deuser A. A Randomized Clinical Trial Assessing Continuous Glucose Monitoring (CGM) Use With Standardized Education With or Without a Family Behavioral Intervention Compared With Fingerstick Blood Glucose Monitoring in Very Young Children With Type 1 Diabetes. Diabetes Care 2020, 44: 464-472. PMID: 33334807, PMCID: PMC9162100, DOI: 10.2337/dc20-1060.Peer-Reviewed Original ResearchConceptsType 1 diabetesBlood glucose monitoringContinuous glucose monitoringFamily behavioral interventionsGlucose monitoringFingerstick blood glucose monitoringBehavioral interventionsSevere hypoglycemic eventsDays/weekYears of ageFear of hypoglycemiaYoung childrenTreatment group comparisonsChildren ages 2Very Young ChildrenHypoglycemic eventsCGM groupDiabetes burdenClinical trialsGlycemic outcomesGlucose levelsPrimary analysisDiabetesBGM groupPercent timeTime spent outside of target glucose range for young children with type 1 diabetes: a continuous glucose monitor study
DiMeglio LA, Kanapka LG, DeSalvo DJ, Anderson BJ, Harrington KR, Hilliard ME, Laffel LM, Tamborlane WV, Van Name MA, Wadwa RP, Willi SM, Woerner S, Wong JC, Miller KM, Group F. Time spent outside of target glucose range for young children with type 1 diabetes: a continuous glucose monitor study. Diabetic Medicine 2020, 37: 1308-1315. PMID: 32096282, PMCID: PMC9065795, DOI: 10.1111/dme.14276.Peer-Reviewed Original ResearchSources and Valence of Information Impacting Parents' Decisions to Use Diabetes Technologies in Young Children <8 Years Old with Type 1 Diabetes
Commissariat P, Whitehouse A, Hilliard M, Miller KM, Harrington KR, Levy W, DeSalvo DJ, Van Name M, Anderson B, Tamborlane W, DiMeglio LA, Laffel L. Sources and Valence of Information Impacting Parents' Decisions to Use Diabetes Technologies in Young Children <8 Years Old with Type 1 Diabetes. Diabetes Technology & Therapeutics 2020, 22: 697-700. PMID: 32077755, PMCID: PMC7718841, DOI: 10.1089/dia.2019.0497.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetes technologyCare providersYoung childrenDiabetes care providersHealth care providersCaregivers of childrenDiabetes technology useSubset of parentsDiabetesCare optionsType 1Most parentsUnderwent content analysisChildrenParents' decisionsProvidersSemi-structured interviewsParentsYears
2019
“I'm essentially his pancreas”: Parent perceptions of diabetes burden and opportunities to reduce burden in the care of children <8 years old with type 1 diabetes
Commissariat PV, Harrington KR, Whitehouse AL, Miller KM, Hilliard ME, Van Name M, DeSalvo DJ, Tamborlane WV, Anderson BJ, DiMeglio LA, Laffel LM. “I'm essentially his pancreas”: Parent perceptions of diabetes burden and opportunities to reduce burden in the care of children <8 years old with type 1 diabetes. Pediatric Diabetes 2019, 21: 377-383. PMID: 31808586, PMCID: PMC7830825, DOI: 10.1111/pedi.12956.Peer-Reviewed Original ResearchConceptsType 1 diabetesGlycemic controlDiabetes burdenSecondary caregiversEmotional burdenChildren's glycemic controlYoung childrenCare of childrenAge 5.2Parents' perceptionsCaregivers' knowledgeClinical centersSemi-structured qualitative interviewsDiabetesDiabetes educationParental burdenHealthcare providersAge groupsInsulin pumpParents' burdenT1DChildren's qualityChild's diabetesParents' knowledgeParents' confidenceGreater parental comfort with lower glucose targets in young children with Type 1 diabetes using continuous glucose monitoring
Van Name MA, Miller KM, Commissariat PV, Whitehouse AL, Harrington KR, Anderson BJ, Mantravadi MG, Levy W, DeSalvo DJ, Tamborlane WV, Hilliard ME, Laffel LM, DiMeglio LA. Greater parental comfort with lower glucose targets in young children with Type 1 diabetes using continuous glucose monitoring. Diabetic Medicine 2019, 36: 1508-1510. PMID: 31295359, PMCID: PMC7027357, DOI: 10.1111/dme.14074.Peer-Reviewed Original ResearchBenefits and Barriers of Continuous Glucose Monitoring in Young Children with Type 1 Diabetes
Hilliard ME, Levy W, Anderson BJ, Whitehouse AL, Commissariat PV, Harrington KR, Laffel LM, Miller KM, Van Name M, Tamborlane WV, DeSalvo DJ, DiMeglio LA. Benefits and Barriers of Continuous Glucose Monitoring in Young Children with Type 1 Diabetes. Diabetes Technology & Therapeutics 2019, 21: 493-498. PMID: 31287721, PMCID: PMC6708264, DOI: 10.1089/dia.2019.0142.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringCGM useDiabetes managementDiabetes careBenefits of CGMYoung childrenGlucose monitoringMean child ageChildren's diabetes careType 1 diabetes managementPainful insertionT1D durationParents of childrenGlucose excursionsImproved sleepClinical strategiesSemistructured qualitative interviewsType 1Parental comfortChild's ageChildrenBehavioural supportMultiple barriersParents' experiencesCaregivers
2017
Management and Family Burdens Endorsed by Parents of Youth <7 Years Old With Type 1 Diabetes
Harrington KR, Boyle CT, Miller KM, Hilliard ME, Anderson BJ, Van Name M, DiMeglio LA, Laffel LM. Management and Family Burdens Endorsed by Parents of Youth <7 Years Old With Type 1 Diabetes. Journal Of Diabetes Science And Technology 2017, 11: 980-987. PMID: 28770627, PMCID: PMC5951003, DOI: 10.1177/1932296817721938.Peer-Reviewed Original ResearchMeSH KeywordsAdultChildChild, PreschoolCost of IllnessDiabetes Mellitus, Type 1FemaleHumansMaleParentsConceptsType 1 diabetesDiabetes managementT1D Exchange Clinic RegistryDuration of diabetesMean hemoglobin A1cFamily impact scoresLow blood sugarQuality of sleepYoung childrenMedical record informationClinical characteristicsHemoglobin A1cSerious complicationsBlood sugarClinic registryMean ageFamily burdenSubstantial burdenParental burdenDiabetesAge groupsInsulin pumpType 1Parents of youthChildren's diabetes managementInsulin Pump Use in Young Children with Type 1 Diabetes: Sociodemographic Factors and Parent-Reported Barriers
Commissariat PV, Boyle CT, Miller KM, Mantravadi MG, DeSalvo DJ, Tamborlane WV, Van Name MA, Anderson BJ, DiMeglio LA, Laffel LM. Insulin Pump Use in Young Children with Type 1 Diabetes: Sociodemographic Factors and Parent-Reported Barriers. Diabetes Technology & Therapeutics 2017, 19: 363-369. PMID: 28581817, PMCID: PMC6435342, DOI: 10.1089/dia.2016.0375.Peer-Reviewed Original ResearchMeSH KeywordsBlood GlucoseBlood Glucose Self-MonitoringChildChild, PreschoolCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHealth Care SurveysHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsMaleMonitoring, AmbulatoryParentsPatient Acceptance of Health CarePatient PreferenceRegistriesSocioeconomic FactorsUnited StatesConceptsBlood glucose monitoringContinuous glucose monitoringGlycemic controlGlucose monitoringMore frequent blood glucose monitoringPump usersYoung childrenFrequent blood glucose monitoringParent-reported reasonsDuration of diabetesOverall glycemic controlInsulin pump useT1D Exchange RegistryParent-reported barriersType 1 diabetesAnnual household incomeClinical characteristicsT1D durationParents of childrenPump therapyCGM usePump useSociodemographic factorsTherapeutic effectivenessType 1Nighttime is the worst time: Parental fear of hypoglycemia in young children with type 1 diabetes
Van Name MA, Hilliard ME, Boyle CT, Miller KM, DeSalvo DJ, Anderson BJ, Laffel LM, Woerner SE, DiMeglio LA, Tamborlane WV. Nighttime is the worst time: Parental fear of hypoglycemia in young children with type 1 diabetes. Pediatric Diabetes 2017, 19: 114-120. PMID: 28429581, PMCID: PMC5650950, DOI: 10.1111/pedi.12525.Peer-Reviewed Original ResearchSchooling diabetes: Use of continuous glucose monitoring and remote monitors in the home and school settings
Erie C, Van Name MA, Weyman K, Weinzimer SA, Finnegan J, Sikes K, Tamborlane WV, Sherr JL. Schooling diabetes: Use of continuous glucose monitoring and remote monitors in the home and school settings. Pediatric Diabetes 2017, 19: 92-97. PMID: 28303678, PMCID: PMC5601025, DOI: 10.1111/pedi.12518.Peer-Reviewed Original Research