2021
Colonic Fermentation and Acetate Production in Youth with and without Obesity
Galuppo B, Cline G, Van Name M, Shabanova V, Wagner D, Kien CL, Santoro N. Colonic Fermentation and Acetate Production in Youth with and without Obesity. Journal Of Nutrition 2021, 151: 3292-3298. PMID: 34494088, PMCID: PMC8562084, DOI: 10.1093/jn/nxab277.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisLean youthLactulose ingestionGut microbiotaHepatic de novo lipogenesisDevelopment of obesityColonic acetateOral doseIntravenous infusionPeripheral circulationColonic fermentationNovo lipogenesisObesityRate of appearanceAge 15Spearman correlationIngestionLactuloseRegression modelsMicrobiotaLesser degreeComplicationsGroupInfusionFerment carbohydrates
2015
Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene
Santoro N, Caprio S, Pierpont B, Van Name M, Savoye M, Parks EJ. Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: e1125-e1132. PMID: 26043229, PMCID: PMC4524990, DOI: 10.1210/jc.2015-1587.Peer-Reviewed Original ResearchConceptsHepatic de novo lipogenesisDe novo lipogenesisFractional de novo lipogenesisCC subjectsNovo lipogenesisLiver lipid synthesisLow-density lipoproteinCarbohydrate drinkGlucose oxidationObese adolescentsObese youthTT subjectsTT genotypeCHO loadHigh basal ratesStudy aimRisk allelesGCKR geneLipogenesisGene variantsBasal rateCommon variantsSubjectsLipid synthesisLower increase