2003
Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats1 1This study was supported by NIH grant HL22273, the R.J. Stransky Foundation, and the Women and Children’s Health Research Foundation of the Children’s Hospital of Buffalo.
Khanna A, Rossman J, Caty MG, Fung H. Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats1 1This study was supported by NIH grant HL22273, the R.J. Stransky Foundation, and the Women and Children’s Health Research Foundation of the Children’s Hospital of Buffalo. Journal Of Surgical Research 2003, 114: 15-24. PMID: 13678693, DOI: 10.1016/s0022-4804(03)00329-9.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAnimalsBileHemodynamicsIntestinal DiseasesIntestinal MucosaIntestinesMaleModels, AnimalNeutrophil ActivationNeutrophil InfiltrationNitric OxideNitroglycerinPermeabilityPlatelet Activating FactorRatsRats, Sprague-DawleyReactive Oxygen SpeciesReperfusion InjuryVasodilator AgentsConceptsIntestinal ischemia-reperfusion injuryIschemia-reperfusion injuryHealth Research FoundationBile flowMean arterial pressureAdministration of nitroglycerinIntestinal barrier functionIntestinal ischemiaMucosal injurySystemic hemodynamicsArterial pressureHypotensive effectIntestinal pathologyChildren's HospitalIntestinal IRIntestinal permeabilityRat modelSustained decreaseExperimental diseaseSystemic effectsNitroglycerinBeneficial effectsPhysiologic functionDifferent dosesBarrier function
2001
Intestinal and Hemodynamic Impairment Following Mesenteric Ischemia/Reperfusion
Khanna A, Rossman J, Fung H, Caty M. Intestinal and Hemodynamic Impairment Following Mesenteric Ischemia/Reperfusion. Journal Of Surgical Research 2001, 99: 114-119. PMID: 11421612, DOI: 10.1006/jsre.2001.6103.Peer-Reviewed Original ResearchConceptsMean arterial pressureR injuryRat modelHeart rateAnimal modelsMesenteric ischemia/reperfusionBarrier functionReperfusion injury resultsSuperior mesenteric arteryIschemia/reperfusionNormal barrier functionArterial pressureHemodynamic effectsIntestinal damageMesenteric occlusionHemodynamic measurementsMesenteric arterySmall bowelFemoral arterySustained fallIntestinal permeabilityInjury resultsAnesthetized ratsIntestinal impairmentHistological disruption
1997
Oxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury
O'Donnell K, Caty M, Zheng S, Rossman J, Azizkhan R. Oxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury. Journal Of Pediatric Surgery 1997, 32: 361-365. PMID: 9044154, DOI: 10.1016/s0022-3468(97)90211-6.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injurySuperior mesenteric arteryMucosal injuryReperfusion injuryMucosal integrityOxygenated perfluorocarbonNew treatment modalitiesR groupMesenteric insufficiencyR injuryMesenteric arteryMucosal functionTreatment modalitiesIntraluminal perfusionMucosal preservationIschemic disordersRat modelIntraluminal flowIntestinal mucosaClinical situationsInjuryIschemiaTissue sectionsReperfusionFeasible technique