2024
Correction: A novel and accurate method for estimating umbilical arterial and venous catheter insertion length
Tambasco C, Shabanova V, Peterec S, Bizzarro M. Correction: A novel and accurate method for estimating umbilical arterial and venous catheter insertion length. Journal Of Perinatology 2024, 44: 1234-1234. PMID: 38872024, DOI: 10.1038/s41372-024-01994-4.Peer-Reviewed Original ResearchMeasuring practice preference variation for quality improvement in neonatal respiratory care
Healy H, Whitesel E, Mao W, Day C, Murphy T, Song C, Williams P, Brachio S, Cham P, Vartanian R, Chin S, Arora P, Bizzarro M, Sink D, Zupancic J, Gupta M. Measuring practice preference variation for quality improvement in neonatal respiratory care. Journal Of Perinatology 2024, 44: 1001-1008. PMID: 38589537, DOI: 10.1038/s41372-024-01956-w.Peer-Reviewed Original ResearchNeonatal intensive care unitNeonatal respiratory careRespiratory careContinuous positive airway pressureLow birth weight infantsNon-invasive positive pressure ventilationBirth weight infantsPositive airway pressurePositive pressure ventilationIntensive care unitWeight infantsAirway pressureMandatory ventilationInvasive ventilationPressure ventilationCare unitClinical scenariosPressure supportObjectivesThe authorsVentilationQuality improvement effortsApneaNeonatologistsNeonatologyNSIGHTThe diagnostic utility of obtaining two blood cultures for the diagnosis of early onset sepsis in neonates
Fleiss N, Shabanova V, Murray T, Gallagher P, Bizzarro M. The diagnostic utility of obtaining two blood cultures for the diagnosis of early onset sepsis in neonates. Journal Of Perinatology 2024, 44: 745-747. PMID: 38409330, DOI: 10.1038/s41372-024-01914-6.Peer-Reviewed Original Research
2023
Reducing MRSA Infection in a New NICU During the COVID-19 Pandemic.
Barrett R, Fleiss N, Hansen C, Campbell M, Rychalsky M, Murdzek C, Krechevsky K, Abbott M, Allegra T, Blazevich B, Dunphy L, Fox A, Gambardella T, Garcia L, Grimm N, Scoffone A, Bizzarro M, Murray T. Reducing MRSA Infection in a New NICU During the COVID-19 Pandemic. Pediatrics 2023, 151 PMID: 36625072, DOI: 10.1542/peds.2022-057033.Peer-Reviewed Original ResearchConceptsInvasive MRSA infectionsInfection prevention strategiesMethicillin-resistant Staphylococcus aureusMRSA infectionOutcome measuresPrevention strategiesCOVID-19 pandemicMultidisciplinary quality improvement initiativeLevel IV NICUSubsequent invasive infectionsMRSA colonization rateCoronavirus disease 2019 (COVID-19) pandemicHealthcare Improvement's ModelQuality improvement initiativesDisease 2019 pandemicEffectiveness of interventionsPersonal protective equipmentSupply chain shortagesHospitalized neonatesInvasive infectionsPatient daysSkin colonizationHand hygieneMost NICUsNICU
2019
585. Shifting Focus Toward Healthcare-Associated Bloodstream Infections: Need for More NICU-Specific NHSN Definitions
Advani S, Murray T, Bizzarro M. 585. Shifting Focus Toward Healthcare-Associated Bloodstream Infections: Need for More NICU-Specific NHSN Definitions. Open Forum Infectious Diseases 2019, 6: s276-s277. PMCID: PMC6810847, DOI: 10.1093/ofid/ofz360.654.Peer-Reviewed Original ResearchCentral line-associated bloodstream infectionsBloodstream infectionsNHSN definitionsChi-square testClinical definitionNational Healthcare Safety Network definitionsNeonatal intensive care unit populationIntensive care unit populationYale-New Haven Children's HospitalLine-associated bloodstream infectionsLevel IV NICUSafety Network definitionsMedian birth weightPercent of patientsSepsis-related mortalityHours of lifeHealthcare-Associated Bloodstream InfectionsMcNemar chi-square testPositive blood culturesSource of infectionGut translocationParenteral nutritionNICU populationRetrospective reviewGestational ageDo Neonatology Fellows get training in percutaneously inserted central catheters placement during their fellowship?
Levit O, Shabanova V, Bizzarro M, Johnston L, M.Ed.. Do Neonatology Fellows get training in percutaneously inserted central catheters placement during their fellowship? Pediatrics 2019, 144: 623-623. DOI: 10.1542/peds.144.2ma7.623.Peer-Reviewed Original Research
2018
1291
Rychalsky M, Lurie M, Sicoli P, Kelly S, Chy C, Bhatt A, Hausser C, Svirskiy V, Liptrot M, Duffy J, Papstein T, Huang E, Anderson M, Rogers M, Labrie K, Lagasse P, Bizzarro M, Grossman M. 1291. Critical Care Medicine 2018, 46: 629. DOI: 10.1097/01.ccm.0000529294.26641.ab.Peer-Reviewed Original Research
2015
Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program
Nelson MU, Bizzarro MJ, Baltimore RS, Dembry LM, Gallagher PG. Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program. Journal Of Clinical Microbiology 2015, 53: 2492-2501. PMID: 26019206, PMCID: PMC4508396, DOI: 10.1128/jcm.00470-15.Peer-Reviewed Original ResearchMeSH KeywordsDNA, BacterialEpidemiological MonitoringFemaleGenetic VariationGenotypeGenotyping TechniquesHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleMethicillin-Resistant Staphylococcus aureusMolecular EpidemiologyMolecular TypingRetrospective StudiesStaphylococcal InfectionsVirulence FactorsConceptsNeonatal intensive care unitMethicillin-resistant Staphylococcus aureusIntensive care unitMRSA colonizationMolecular epidemiologyCare unitStaphylococcal cassette chromosome mec type IIAccessory gene regulator (agr) groupsMRSA colonization rateToxic shock syndrome toxinAgr group 1Exfoliative toxin AStaphylococcus aureusPotential virulence factor genesVirulence factor genesMRSA infectionSignificant morbidityClinical differencesPatient daysPulsed-field gel electrophoresisToxin AUSA300 strainGroup 1Continued vigilanceInfectionNeonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci
Bizzarro MJ, Shabanova V, Baltimore RS, Dembry LM, Ehrenkranz RA, Gallagher PG. Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci. The Journal Of Pediatrics 2015, 166: 1193-1199. PMID: 25919728, PMCID: PMC4413005, DOI: 10.1016/j.jpeds.2015.02.009.Peer-Reviewed Original ResearchConceptsEarly-onset sepsisLate-onset sepsisNeonatal intensive care unitCoagulase-negative staphylococciIntensive care unitCare unitLevel IV neonatal intensive care unitEpisodes of sepsisLow birth weightInfection prevention initiativesInfection prevention effortsPercent of casesGroup B streptococciHospital courseSepsis episodesMost infantsBirth weightCommon organismB streptococciSepsisOutcome dataAdditional surveillancePrevention effortsStudy periodInfants
2014
Methicillin-resistant Staphylococcus aureus : impact on care in the neonatal unit
Nelson M, Bizzarro M, Gallagher P. Methicillin-resistant Staphylococcus aureus : impact on care in the neonatal unit. 2014, 41-61. DOI: 10.2217/ebo.13.571.Peer-Reviewed Original ResearchNeonatal intensive care unitMethicillin-resistant Staphylococcus aureusMRSA transmissionTreatment of MRSAIntensive care unitAppropriate treatment regimensMRSA colonizationNeonatal morbidityMRSA acquisitionCare unitIll infantsNeonatal unitSignificant morbidityTreatment regimensRisk factorsMRSA strainsPrevention strategiesNeonatesInfectionPervasive pathogenEarly detectionMorbidityStaphylococcus aureusInfantsEpidemiologyInhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease
Bizzarro M, Gross I, Barbosa FT. Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease. Cochrane Database Of Systematic Reviews 2014, 2014: cd005055. PMID: 24991723, PMCID: PMC10728583, DOI: 10.1002/14651858.cd005055.pub3.Peer-Reviewed Original ResearchConceptsMean pulmonary arterial pressurePulmonary hypertensive crisisCongenital heart diseaseLong-term mortalityPulmonary hypertensionHeart rateMethaemoglobin levelsNeurodevelopmental disabilitiesHospital stayArterial pressureNitric oxidePostoperative managementHeart diseaseEfficacy of iNOUse of iNOPulmonary arterial pressureSystemic blood pressureArterial oxygen tensionLength of stayMarkers of toxicityConventional managementHypertensive crisisPostoperative administrationPulmonary vasodilationSecondary outcomesTime for a Neonatal-Specific Consensus Definition for Sepsis
Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA. Time for a Neonatal-Specific Consensus Definition for Sepsis. Pediatric Critical Care Medicine 2014, 15: 523-528. PMID: 24751791, PMCID: PMC4087075, DOI: 10.1097/pcc.0000000000000157.Peer-Reviewed Original ResearchConceptsConsensus definitionNeonatal sepsisPreterm neonatesTerm neonatesPediatric consensus definitionsHost immune responseSepsis criteriaDevastating conditionLaboratory criteriaDiagnostic challengePediatric literatureClinical trialsObservational studyImmune responseSepsisNeonatesNew drugsDisease epidemiologyChildrenFuture trainingIntensivistsVariable definitionsEpidemiologyDiseaseTrialsLow‐Dose Intravenous Soybean Oil Emulsion for Prevention of Cholestasis in Preterm Neonates
Levit OL, Calkins KL, Gibson LC, Kelley‐Quon L, Robinson DT, Elashoff DA, Grogan TR, Li N, Bizzarro MJ, Ehrenkranz RA. Low‐Dose Intravenous Soybean Oil Emulsion for Prevention of Cholestasis in Preterm Neonates. Journal Of Parenteral And Enteral Nutrition 2014, 40: 374-382. PMID: 24963025, PMCID: PMC4537394, DOI: 10.1177/0148607114540005.Peer-Reviewed Original ResearchConceptsDays of lifeIntravenous fat emulsionPreterm neonatesPrimary outcomeGestational ageControl groupControl doseFat emulsionDays of PNFull enteral feedsPrevention of cholestasisMajor neonatal morbidityHours of lifeEffective preventive strategiesLow groupHospital stayNeonatal morbidityBaseline characteristicsParenteral nutritionSecondary outcomesEnteral feedsEssential fatty acidsPremature infantsLiver diseaseTotal bilirubinEar drainage and the role of sepsis evaluations in the neonatal intensive care unit
Khattab M, Cannon‐Heinrich C, Bizzarro MJ. Ear drainage and the role of sepsis evaluations in the neonatal intensive care unit. Acta Paediatrica 2014, 103: 732-736. PMID: 24635016, PMCID: PMC4320968, DOI: 10.1111/apa.12636.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitIntensive care unitEar drainageSepsis evaluationCare unitTape removalMedian gestational ageExternal auditory canalGestational ageAuditory canalInflammatory processUnnecessary interventionsAnti-adhesive productDrainageInterventionEarOnsetBirthweightAdmissionCasesEvaluationWeeksClinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis
Levit O, Bhandari V, Li FY, Shabanova V, Gallagher PG, Bizzarro MJ. Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis. The Pediatric Infectious Disease Journal 2014, 33: 143-146. PMID: 24418836, PMCID: PMC3917323, DOI: 10.1097/inf.0000000000000024.Peer-Reviewed Original ResearchConceptsLate-onset sepsisLow birth weight infantsBirth weight infantsIndependent risk factorLaboratory factorsWeight infantsVLBW infantsRisk factorsCases of LOSEpisodes of LOSRisk of LOSFungal LOSNeonatal intensive care unitMultivariate logistic regression analysisSepsis-related deathsIntensive care unitOnset of illnessSepsis-associated mortalityGram-positive infectionsLogistic regression analysisOnset of diseasePresentation of illnessComposite risk profileLaboratory signsNecrotizing enterocolitis
2013
Concurrent Bloodstream Infections in Infants with Necrotizing Enterocolitis
Bizzarro MJ, Ehrenkranz RA, Gallagher PG. Concurrent Bloodstream Infections in Infants with Necrotizing Enterocolitis. The Journal Of Pediatrics 2013, 164: 61-66. PMID: 24139563, DOI: 10.1016/j.jpeds.2013.09.020.Peer-Reviewed Original ResearchConceptsBloodstream infectionsPost-NECNegative bacilliLate-onset bloodstream infectionConcurrent bloodstream infectionHospital course dataMean gestational ageCases of NECDiagnosis of NECOnset of diseaseMicrobiologic etiologyUnderappreciated complicationMicrobiologic dataNecrotizing enterocolitisGestational ageRetrospective reviewSingle centerSurgical interventionBirth weightRisk factorsHigher oddsInfantsNECEnterocolitisInfectionTemporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit
Bizzarro MJ, Li FY, Katz K, Shabanova V, Ehrenkranz RA, Bhandari V. Temporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit. Journal Of Perinatology 2013, 34: 33-38. PMID: 24071904, DOI: 10.1038/jp.2013.122.Peer-Reviewed Original ResearchConceptsSevere ROPRetinopathy of prematurityNeonatal intensive care unitIntensive care unitCare unitMultivariate analysisBronchopulmonary dysplasia/deathTarget saturation rangePost-intervention evaluationPreterm neonatesOxygen saturationStaff educationSurgeryInfantsMultidisciplinary groupSignificant reductionHyperoxiaDeathExposureSignal extraction technologyMorbidityPrematurityRetinopathyNeonatesNeutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis
Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz RA, Rinder HM, Bhandari V. Neutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis. American Journal Of Perinatology 2013, 31: 021-030. PMID: 23456906, DOI: 10.1055/s-0033-1334453.Peer-Reviewed Original ResearchConceptsCulture-proven sepsisClinical sepsisNeutrophil CD64CD64 indexNeonatal sepsisHematologic criteriaSingle-centre neonatal intensive care unitEarly-onset clinical sepsisNeonatal intensive care unitNeutrophil CD64 indexProspective observational cohortAbsolute neutrophil countNormal birth weightIntensive care unitAbsolute band countNegative predictive valueAdditional markersSepsis evaluationNeutrophil countObservational cohortCare unitBirth weightHematologic parametersSepsisCD64
2011
Granulicatella adiacens and Early-Onset Sepsis in Neonate
Bizzarro M, Callan D, Farrel P, Dembry L, Gallagher P. Granulicatella adiacens and Early-Onset Sepsis in Neonate. Emerging Infectious Diseases 2011 DOI: 10.3201/eid1710.101967_article.htm.Peer-Reviewed Original ResearchCongenital Diaphragmatic Hernia: Updates and Outcomes
Benjamin J, Bizzarro M, Cotten C. Congenital Diaphragmatic Hernia: Updates and Outcomes. NeoReviews 2011, 12: e439-e452. DOI: 10.1542/neo.12-8-e439.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCongenital diaphragmatic herniaHigh-frequency mechanical ventilationLong-term morbidityFollow-up settingLong-term outcomesSubstantial mortality riskCDH survivorsUtero interventionSurgical repairMechanical ventilationBasic pathophysiologyFetal treatmentComplex patientsDiaphragmatic herniaAffected patientsInpatient arenaMortality riskTherapeutic strategiesMedical careNitric oxidePrenatal identificationMultidisciplinary approachPatientsOutcomesRecent updates