2024
Testing in functional constipation—What's new and what works
Rodriguez L. Testing in functional constipation—What's new and what works. Alimentary Pharmacology & Therapeutics 2024, 60: s30-s41. PMID: 38940015, DOI: 10.1111/apt.17857.Peer-Reviewed Original ResearchColonic manometryFecal incontinenceConventional therapyRadiopaque markersFunctional constipationNon-retentive fecal incontinenceDiagnostic studiesFailed medical therapyLumbar spine MRIRecto-anal inhibitory reflexAnal resting pressureAbdominal X-raySpine MRIAnorectal manometryMedical therapyPaediatric constipationSurgical interventionClinical findingsInhibitory reflexEvaluate anatomySpinal abnormalitiesColonic transitMedical historyPaediatric gastroenterologistsConstipationSu2039 A CENTRALIZED INTERPRETATION OF DE-IDENTIFIED PEDIATRIC HIGH-RESOLUTION MANOMETRY STUDIES FROM A MULTICENTER COHORT: CHICAGO CLASSIFICATION V4.0 PROTOCOL IS OFTEN NOT FOLLOWED, BUT DIAGNOSIS CHANGES ARE MOSTLY NON-ACTIONABLE
Davis T, Rogers B, Llanos-Chea A, Krasaelap A, Banks D, Ambartsumyan L, Sanchez R, Yacob D, Baker C, Rey A, Desai C, Rottier A, Jayaraman M, Khorrami C, Dorfman L, El-Chammas K, Mansi S, Chiou E, Chumpitazi B, Puri N, Rodriguez L, Garza J, Saps M, Patel D, Gyawali C. Su2039 A CENTRALIZED INTERPRETATION OF DE-IDENTIFIED PEDIATRIC HIGH-RESOLUTION MANOMETRY STUDIES FROM A MULTICENTER COHORT: CHICAGO CLASSIFICATION V4.0 PROTOCOL IS OFTEN NOT FOLLOWED, BUT DIAGNOSIS CHANGES ARE MOSTLY NON-ACTIONABLE. Gastroenterology 2024, 166: s-902. DOI: 10.1016/s0016-5085(24)02560-5.Peer-Reviewed Original ResearchPersistent and newly developed gastrointestinal symptoms after surgery for intestinal malrotation in children: Dysmotility or disorders of gut and brain interaction?
Patel D, Banks D, Hira B, Ford M, Ambartsumyan L, Rodriguez L. Persistent and newly developed gastrointestinal symptoms after surgery for intestinal malrotation in children: Dysmotility or disorders of gut and brain interaction? Journal Of Pediatric Gastroenterology And Nutrition 2024, 78: 827-835. PMID: 38451033, DOI: 10.1002/jpn3.12178.Peer-Reviewed Original ResearchResolution of symptomsIntestinal malrotationGI symptomsFollow-upIncidental diagnosisPersistent gastrointestinal (GIPresence of postoperative symptomsPediatric tertiary care centerLong-term outcome of childrenMedian follow-upFactors associated with lackMulticenter retrospective studyPostoperative follow-upTertiary care centerAge of diagnosisTime to diagnosisLong-term outcomesRome IV criteriaGastrointestinal (GIOutcomes of childrenIdiopathic diagnosisOutcome variablesAssociated with disordersAssociation of demographicsClinical presentation
2023
The Clinical Utility of Antroduodenal Manometry in the Evaluation of Children with Upper Gastrointestinal Symptoms
Arbizu R, Trauernicht S, Pinillos S, Nurko S, Rodriguez L. The Clinical Utility of Antroduodenal Manometry in the Evaluation of Children with Upper Gastrointestinal Symptoms. Journal Of Pediatric Gastroenterology And Nutrition 2023, 77: 734-740. PMID: 37756372, DOI: 10.1097/mpg.0000000000003956.Peer-Reviewed Original ResearchConceptsGroup B symptomsUpper gastrointestinal symptomsIdiopathic etiologyB symptomsGastrointestinal symptomsPhase IIITreatment responseInitial successful responseIntestinal phase IIIOverall treatment responseSuccessful treatment responseSmall bowel motilityEvaluation of childrenSuccessful responseManometry measuresUGI symptomsAbdominal distentionAntroduodenal manometryPredominant symptomBowel motilityRetrospective reviewClinical findingsClinical utilitySymptomsEtiologyHirschsprung's disease associated enterocolitis: A comprehensive review
Gershon E, Rodriguez L, Arbizu R. Hirschsprung's disease associated enterocolitis: A comprehensive review. World Journal Of Clinical Pediatrics 2023, 12: 68-76. PMID: 37342453, PMCID: PMC10278080, DOI: 10.5409/wjcp.v12.i3.68.Peer-Reviewed Original ResearchHirschsprung’s disease associated enterocolitisHirschsprung's diseaseAffected bowel segmentCurrent therapeutic optionsIntestinal barrier functionIntestinal dysmotilityInflammatory complicationsPostoperative periodDistal bowelSurgical treatmentAssociated enterocolitisBowel segmentsClinical presentationFunctional obstructionTherapeutic optionsMucosal defenseGanglion cellsNeural crest cellsBarrier functionCongenital disorderDiseaseDiagnosisCrest cellsComprehensive reviewTreatmentGastrointestinal Symptoms After Surgery for Intestinal Malrotation
Patel D, Halverson C, Jayaraman M, Ambartsumyan L, Rodriguez L. Gastrointestinal Symptoms After Surgery for Intestinal Malrotation. Journal Of Pediatric Gastroenterology And Nutrition 2023, 77: 316-318. PMID: 37256844, DOI: 10.1097/mpg.0000000000003840.Peer-Reviewed Original ResearchClinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo‐Obstruction
Colliard K, Nurko S, Flores A, Rodriguez L. Clinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo‐Obstruction. Journal Of Pediatric Gastroenterology And Nutrition 2023, 77: 327-331. PMID: 37229777, DOI: 10.1097/mpg.0000000000003841.Peer-Reviewed Original ResearchConceptsAntroduodenal manometryDefecation disordersPostprandial responseGroup BChronic Intestinal Pseudo-ObstructionIntestinal Pseudo-ObstructionNormal postprandial responseModerate agreementSmall bowel motilityLogistic regression analysisOstomy closurePseudo-ObstructionBowel motilityRetrospective reviewIleal motilityIndication groupGroup AClinical utilityYounger agePatientsMotility patternsPhase IIIMotor complexDisordersManometryPediatric Neurogastroenterology and Motility Disorders What Role Does Endoscopy Play?
Khlevner J, Patel D, Rodriguez L. Pediatric Neurogastroenterology and Motility Disorders What Role Does Endoscopy Play? Gastrointestinal Endoscopy Clinics Of North America 2023, 33: 379-399. PMID: 36948752, DOI: 10.1016/j.giec.2022.10.004.Peer-Reviewed Original ResearchConceptsPaediatric neurogastroenterologyMotility disordersOral endoscopic myotomyTherapeutic gastrointestinal endoscopyIncisional therapySmall bowelEndoscopic myotomyAnorectal disordersGastrointestinal endoscopyDiagnostic endoscopyFunctional lumenAxis interactionTherapeutic landscapeNovel modalityDisordersNeurogastroenterologyEndoscopyBowelMyotomyEsophagealColonicTherapyClinical utility of colonic low‐amplitude propagating contractions in children with functional constipation
Colliard K, Patel D, Nurko S, Rodriguez L. Clinical utility of colonic low‐amplitude propagating contractions in children with functional constipation. Neurogastroenterology & Motility 2023, 35: e14543. PMID: 37096634, DOI: 10.1111/nmo.14543.Peer-Reviewed Original ResearchConceptsFunctional constipationLogistic regressionClinical utilityPediatric functional constipationConstipation groupRetrospective reviewColonic enemaClinical significanceLAPCConstipationNeuromuscular integrityLarger studyPatientsOutcomesChildrenAssociationContractionHigher proportionHAPCsGroupRegressionIleostomyEnemaPediatric neurogenic bowel dysfunction: ICCS review document
Kelly M, Benninga M, Yang S, Franco I, Payne C, Wei C, Rodriguez L, Beierwaltes P, Tanaka S. Pediatric neurogenic bowel dysfunction: ICCS review document. Journal Of Pediatric Urology 2023, 19: 232-239. PMID: 36828731, DOI: 10.1016/j.jpurol.2023.01.015.Peer-Reviewed Original ResearchConceptsInternational Children's Continence SocietyNeurogenic bowel dysfunctionBowel dysfunctionLower urinary tract dysfunctionUrinary tract dysfunctionQuality of lifeNon-systematic reviewEvidence-based informationTract dysfunctionMonitoring of individualsHistory takingPhysical assessmentDysfunctionDiagnostic studiesCurrent literatureChildrenReviewCare
2022
Diverting Ileostomy in Children With Functional Constipation
Rodriguez L, Colliard K, Nurko S, Flores A, Buchmiller TL. Diverting Ileostomy in Children With Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 578-583. PMID: 35897140, DOI: 10.1097/mpg.0000000000003579.Peer-Reviewed Original ResearchConceptsFunctional constipationOstomy closurePediatric functional constipationInstitutional review board approvalReview board approvalEnema failureColon motilityFurther surgeryInvasive evaluationRetrospective studySurgical interventionOstomyBoard approvalUseful interventionLarger studyConstipationSuccessful responsePatientsSurgeryChildrenRole of CMDemographicsAssociationInterventionIndicationsEvaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum
Rodriguez L, Morley‐Fletcher A, Winter H, Timothy B. Evaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 450-454. PMID: 35830732, DOI: 10.1097/mpg.0000000000003561.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseSymptom correlationBravo wirelessReflux diseaseEvaluation of GERDMedian reflux indexNon-ASD childrenSignificant side effectsASD childrenNormal esophageal mucosaAutism spectrum disorderSelf-injurious behaviorChest painReflux indexGER episodesGER symptomsMale predominanceAbnormal studiesPatient populationEsophageal mucosaSupine positionLarge cohortSide effectsBehavioral symptomsStudy durationA Guide to Establishing a Pediatric Neurogastroenterology and Motility Program
Patel D, Sood V, Ambartsumyan L, Wheeler J, Kaul A, Khlevner J, Darbari A, Rodriguez L. A Guide to Establishing a Pediatric Neurogastroenterology and Motility Program. Journal Of Pediatric Gastroenterology And Nutrition 2022, 74: 435-439. PMID: 35045556, DOI: 10.1097/mpg.0000000000003385.Peer-Reviewed Original ResearchElectrogastrography, Breath Tests, Ultrasonography, Transit Tests, Wireless Motility Capsule, and Cine-MRI
Arbizu R, Rodriguez L. Electrogastrography, Breath Tests, Ultrasonography, Transit Tests, Wireless Motility Capsule, and Cine-MRI. 2022, 207-220. DOI: 10.1007/978-3-031-15229-0_17.Peer-Reviewed Original ResearchWhole gut transitWireless motility capsuleGastrointestinal tractMotility capsuleBreath testMore pediatric studiesCine magnetic resonance imagingEvaluation of childrenWhole gastrointestinal tractMotility disordersGastric emptyingPediatric studiesNoninvasive testsMyoelectrical activityTransit testTransit studiesInvasive interventionsAdjunct testGut transitMotility studiesClinical diagnosisResonance imagingClinical settingLuminal volumeUltrasonography
2021
Upper Gastrointestinal Functional and Motility Disorders in Children
Miller J, Khlevner J, Rodriguez L. Upper Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1237-1253. PMID: 34736587, DOI: 10.1016/j.pcl.2021.07.009.Peer-Reviewed Original ResearchConceptsMotility disordersNew diagnostic studiesUpper gastrointestinal tractAbdominal painChest painMechanisms of diseaseClinical presentationMotor functionGastrointestinal tractGastrointestinal physiologyTherapeutic interventionsDiagnostic studiesDisordersNormal functionPainChildrenDysphagiaNauseaVomitingDysfunctionEsophagusSymptomsStomachDiseaseDiagnosisLower Gastrointestinal Functional and Motility Disorders in Children
Arbizu R, Freiberg B, Rodriguez L. Lower Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1255-1271. PMID: 34736588, DOI: 10.1016/j.pcl.2021.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnorectal MalformationsBiopsyChildChild, PreschoolColonic DiseasesConstipationErythromycinFemaleGastrointestinal DiseasesGastrointestinal MotilityHirschsprung DiseaseHumansInfantIntestinal Pseudo-ObstructionIntestine, SmallLower Gastrointestinal TractMaleManometryNutritional StatusQuality of LifeConceptsMotility disordersSignificant morbidityTherapeutic interventionsColorectal disordersPediatric gastroenterologistsClinical presentationSmall bowelGastrointestinal disordersCommon complaintDiagnostic evaluationSmall intestineDisordersMorbidityComplicationsSuch interventionsInterventionSocial stigmaPoor qualityBowelAnorectumGastroenterologistsColonMortalityComplaintsIntestineCan Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies?
Arbizu RA, Amicangelo M, Rodriguez L, Nurko S. Can Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies? Journal Of Pediatric Gastroenterology And Nutrition 2021, 74: 33-37. PMID: 34478251, DOI: 10.1097/mpg.0000000000003283.Peer-Reviewed Original ResearchConceptsIntra-anal pressuresRectoanal inhibitory reflexAnorectal manometryInhibitory reflexAbsent rectoanal inhibitory reflexInternal anal sphincter relaxationNormal rectoanal inhibitory reflexAnal sphincter relaxationAnorectal manometry studyBalloon distentionIAS relaxationSpinal neuropathyIntractable constipationObstructive symptomsSphincter relaxationProspective studyAnesthesia inductionManometry studiesPatientsPropofolDisease repairLatency timeConstipationAnesthesiaReflexMelanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation
Chen JJ, Kitzia Colliard RN, Nurko S, Rodriguez L. Melanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation. Digestive Diseases And Sciences 2021, 67: 3922-3928. PMID: 34379221, DOI: 10.1007/s10620-021-07191-z.Peer-Reviewed Original ResearchConceptsPediatric functional constipationMelanosis coliFunctional constipationColonic manometryColonic motilityMarker of severityTreatment of constipationRate of surgeryColonic dysmotilityColonic biopsiesMedian agePediatric patientsManometry resultsMedication historyMethodsProspective studyPatient groupResultsA totalSurgical historyPathologic resultsConstipationPatientsCatheter positionDemographic dataSubsequent needSignificant differences
2020
Diagnostic and clinical utility of the wireless motility capsule in children: A study in patients with functional gastrointestinal disorders
Rodriguez L, Heinz N, Colliard K, Amicangelo M, Nurko S. Diagnostic and clinical utility of the wireless motility capsule in children: A study in patients with functional gastrointestinal disorders. Neurogastroenterology & Motility 2020, 33: e14032. PMID: 33184926, DOI: 10.1111/nmo.14032.Peer-Reviewed Original ResearchConceptsWireless motility capsuleColon transitGastrointestinal symptomsCapsule retentionMotility capsuleLower gastrointestinal symptomsRadiopaque marker studiesFunctional gastrointestinal symptomsFunctional gastrointestinal disordersNuclear medicine gastricGastrointestinal motilityGastrointestinal disordersTransit abnormalitiesClinical utilityGastric transitSymptomsLarger studyPatientsInterpretation agreementMarker studiesMotility parametersStudy interpretationCROMSignificant correlationChildrenEvaluation of Fecal Incontinence in Pediatric Functional Constipation
Morera C, Nurko S, Rodriguez L. Evaluation of Fecal Incontinence in Pediatric Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2020, 72: 361-365. PMID: 33560756, DOI: 10.1097/mpg.0000000000002978.Peer-Reviewed Original ResearchConceptsPediatric functional constipationFecal incontinenceFunctional constipationColonic manometryMedian anal resting pressureAnal resting pressureMore patientsResting pressureAbnormal studiesConventional therapyMale genderTreatment outcomesClinical dataConstipationNormal studiesTherapy responseMeal responseIncontinencePatientsMultivariate analysisMotility studiesTherapyNormal armLow responseManometry