2022
Evaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum
Rodriguez L, Morley‐Fletcher A, Winter H, Timothy B. Evaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 450-454. PMID: 35830732, DOI: 10.1097/mpg.0000000000003561.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseSymptom correlationBravo wirelessReflux diseaseEvaluation of GERDMedian reflux indexNon-ASD childrenSignificant side effectsASD childrenNormal esophageal mucosaAutism spectrum disorderSelf-injurious behaviorChest painReflux indexGER episodesGER symptomsMale predominanceAbnormal studiesPatient populationEsophageal mucosaSupine positionLarge cohortSide effectsBehavioral symptomsStudy duration
2020
Long‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy
Bonilla S, Nurko S, Rodriguez L. Long‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy. Journal Of Pediatric Gastroenterology And Nutrition 2020, 71: 288-291. PMID: 32459741, DOI: 10.1097/mpg.0000000000002795.Peer-Reviewed Original ResearchConceptsConventional therapyLong-term usePediatric constipationFunctional constipationSide effectsTertiary care children's hospitalFrequency of BMPediatric functional constipationBowel movement frequencyLong-term followLong-term treatmentMedian doseRescue therapyMedian durationStandard therapyOsmotic laxativesRetrospective reviewPediatric populationChildren's HospitalStimulant laxativesMedian numberConstipationPatientsTreatment durationFavorable response
2013
Safety and Efficacy of Cyproheptadine for Treating Dyspeptic Symptoms in Children
Rodriguez L, Diaz J, Nurko S. Safety and Efficacy of Cyproheptadine for Treating Dyspeptic Symptoms in Children. The Journal Of Pediatrics 2013, 163: 261-267. PMID: 23419589, PMCID: PMC3661691, DOI: 10.1016/j.jpeds.2012.12.096.Peer-Reviewed Original ResearchConceptsEfficacy of cyproheptadineDyspeptic symptomsEarly vomitingSide effectsMultivariate analysisRetrospective open-label studyOpen-label studyUpper gastrointestinal symptomsPotent serotonin antagonistUse of cyproheptadineLack of responseLate vomitingAbdominal painGastrointestinal symptomsAntroduodenal manometryFunctional dyspepsiaNissen fundoplicationSerotonin antagonistsFirst therapyGastric emptyingFurther interventionTherapy responseVomitingCyproheptadineResponse rate