2015
Use of Clostridium botulinum toxin in gastrointestinal motility disorders in children
Arbizu RA, Rodriguez L. Use of Clostridium botulinum toxin in gastrointestinal motility disorders in children. World Journal Of Gastrointestinal Endoscopy 2015, 7: 433-437. PMID: 25992183, PMCID: PMC4436912, DOI: 10.4253/wjge.v7.i5.433.Commentaries, Editorials and LettersGastrointestinal motility disordersMotility disordersBotulinum toxin type APatients 12 yearsToxin type AExcessive neural activityTreatment of strabismusBotulinum neurotoxin type AType ANeurotoxin type ABowel perforationPresynaptic releaseTherapeutic applicationsClostridium botulinum toxinSignificant complicationsMinor painCentral originBotulinum toxinGastroenterological conditionsAllergic reactionsParalytic diseaseSignificant paralysisGastrointestinal tractObligate anaerobic bacteriaClinical experience
2008
Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction
Irani K, Rodriguez L, Doody DP, Goldstein AM. Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction. Pediatric Surgery International 2008, 24: 779-783. PMID: 18443801, DOI: 10.1007/s00383-008-2171-3.Peer-Reviewed Original ResearchConceptsInternal anal sphincter dysfunctionAnal sphincter dysfunctionIntrasphincteric injectionSphincter dysfunctionIntractable constipationPediatric patientsBotulinum toxinIAS dysfunctionAbnormal anorectal manometryRectoanal inhibitory reflexTreatment of constipationDuration of effectChronic constipationPostoperative incontinenceRefractory constipationInhibitory reflexAnorectal manometryResting pressureRetrospective reviewBotox injectionHirschsprung's diseaseConstipationEffective treatmentPatientsDysfunction