2017
Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation
Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation. Neurogastroenterology & Motility 2017, 29 PMID: 28317231, PMCID: PMC5466533, DOI: 10.1111/nmo.13050.Peer-Reviewed Original ResearchConceptsDay 1Day 2Normal studiesAbnormal studiesProportion of patientsSame dayStudy interpretationColon manometryGastrocolonic responseRefractory constipationProspective evaluationManometry parametersMotility indexPatientsChallenge phaseAbstractTextAnesthesiaCatheterStudy parametersColonoscopyDaysConstipationHAPCsManometryStudy
2015
Effect of anesthesia on gastroesophageal reflux in children: a study using BRAVO wireless pH study measurements
Rodriguez L, Morley-Fletcher A, Souza A, Rosengaus L, Nurko S. Effect of anesthesia on gastroesophageal reflux in children: a study using BRAVO wireless pH study measurements. Neurogastroenterology & Motility 2015, 27: 1553-1558. PMID: 26264213, PMCID: PMC4624481, DOI: 10.1111/nmo.12652.Peer-Reviewed Original ResearchConceptsEffects of anesthesiaGastroesophageal refluxBravo wirelessStudy interpretationAnesthesia effectProportion of studiesRole of anesthesiaGER parametersCapsule placementAnesthesiaCutoff valueStudy durationAbstractTextSignificant increaseChildrenRefluxSignificant changesStudy measurementsDaysHoursBlock timePatientsStudyProportion
2013
Relationship between postprandial metabolomics and colon motility in children with constipation
Rodriguez L, Roberts LD, LaRosa J, Heinz N, Gerszten R, Nurko S, Goldstein AM. Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterology & Motility 2013, 25: 420-e299. PMID: 23421516, PMCID: PMC3877617, DOI: 10.1111/nmo.12086.Peer-Reviewed Original ResearchConceptsTreatment of constipationColonic motilityMotility indexMotility patternsNormal postprandial increasePostprandial motility patternCohort of childrenPostprandial metabolic changesSignificant metabolite changesColon manometryColon motilityConstipated childrenProspective studyStandardized mealKynurenic acidMeal challengePostprandial increasePostprandial changesMultiple time pointsConstipationLipid metabolitesPotential metabolic targetsAbstractTextSpecific metabolitesMetabolic changes
2012
Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility
Rodriguez L, Nurko S, Flores A. Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility. Neurogastroenterology & Motility 2012, 25: 140-e81. PMID: 23035840, PMCID: PMC3546133, DOI: 10.1111/nmo.12018.Peer-Reviewed Original ResearchConceptsAntegrade continence enemaColon manometryACE decreaseContinence enemaColon motilityDefecation disordersOlder ageReview of childrenGastrocolonic responseMotility indexOnly predictorMultivariate analysisDiscontinuationAbstractTextEnemaOutcomesPatientsSignificant increaseChildrenSuccessful decreaseDisordersAgeHAPCsMotilityCM changesInternal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex?
Rodriguez L, Siddiqui A, Nurko S. Internal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex? Neurogastroenterology & Motility 2012, 24: 1023-e545. PMID: 22757618, PMCID: PMC3465462, DOI: 10.1111/j.1365-2982.2012.01965.x.Peer-Reviewed Original ResearchConceptsHigh-amplitude peristaltic contractionsInternal anal sphincter relaxationAnal sphincter relaxationIAS relaxationSphincter relaxationAnal residual pressureManometry tracingsDefecation disordersConstipated childrenAnal relaxationHepatic flexureResting pressureDistal colonPeristaltic contractionsColonAbstractTextConstipationContraction propagationReflexChildrenImportant proportionContractionMost casesPatientsBisacodyl