Featured Publications
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
Barmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, Jones K, Habet V, Campbell M, Sumida T, Kontorovich A, Bogunovic D, Oliveira C, Steele J, Hall E, Pena-Hernandez M, Monteiro V, Lucas C, Ring A, Omer S, Iwasaki A, Yildirim I, Lucas C. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis. Science Immunology 2023, 8: eadh3455-eadh3455. PMID: 37146127, PMCID: PMC10468758, DOI: 10.1126/sciimmunol.adh3455.Peer-Reviewed Original ResearchConceptsMRNA vaccinesSARS-CoV-2 mRNA vaccinesSARS-CoV-2 mRNA vaccinationC-reactive protein levelsB-type natriuretic peptidePeripheral blood mononuclear cellsCardiac tissue inflammationDeep immune profilingSerum soluble CD163Vaccine-associated myocarditisCohort of patientsBlood mononuclear cellsCytotoxic T cellsLate gadolinium enhancementHypersensitivity myocarditisElevated troponinMRNA vaccinationImaging abnormalitiesNK cellsImmune profilingKiller cellsMyeloid responseNatriuretic peptideHumoral mechanismsInflammatory cytokinesComprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia
Sasse A, Feher A, Thorn S, Fahey J, Keeshan B, Sinusas A, Mojibian H, Steele J. Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia. Circulation Cardiovascular Imaging 2023, 16: 597-600. PMID: 37092334, DOI: 10.1161/circimaging.122.015158.Peer-Reviewed Case Reports and Technical NotesComputed Tomographic 3-Dimensional Virtual Dissection Aiding in Diagnosis and Surgical Planning of a Rare Form of Obstructed Supracardiac Total Anomalous Pulmonary Venous Connection With an Unusual Scimitar-Like Arrangement
Leone DM, Gruber PJ, Pesce M, Lee M, Brown C, Ghiroli S, Steele JM. Computed Tomographic 3-Dimensional Virtual Dissection Aiding in Diagnosis and Surgical Planning of a Rare Form of Obstructed Supracardiac Total Anomalous Pulmonary Venous Connection With an Unusual Scimitar-Like Arrangement. World Journal For Pediatric And Congenital Heart Surgery 2022, 14: 233-235. PMID: 36322621, DOI: 10.1177/21501351221133771.Peer-Reviewed Case Reports and Technical NotesConceptsSupracardiac total anomalous pulmonary venous connectionTotal anomalous pulmonary venous connectionAnomalous pulmonary venous connectionPulmonary venous connectionVenous connectionTomographic angiographyObstructed supracardiac total anomalous pulmonary venous connectionComplex congenital heart diseaseSurgical planningCongenital heart diseaseMembrane oxygenationSurgical managementRare presentationPreoperative imagingExcellent outcomesHeart diseaseRare formAnatomical delineationDissection techniqueNoncardiac structuresPresurgical planningAdjustment of flowAngiographyTechnique aidsMyocardial involvement in children with post-COVID multisystem inflammatory syndrome: a cardiovascular magnetic resonance based multicenter international study-the CARDOVID registry.
Aeschlimann FA, Misra N, Hussein T, Panaioli E, Soslow JH, Crum K, Steele JM, Huber S, Marcora S, Brambilla P, Jain S, Navallas M, Giuli V, Rücker B, Angst F, Patel MD, Azarine A, Caro-Domínguez P, Cavaliere A, Di Salvo G, Ferroni F, Agnoletti G, Bonnemains L, Martins D, Boddaert N, Wong J, Pushparajah K, Raimondi F. Myocardial involvement in children with post-COVID multisystem inflammatory syndrome: a cardiovascular magnetic resonance based multicenter international study-the CARDOVID registry. Journal Of Cardiovascular Magnetic Resonance : Official Journal Of The Society For Cardiovascular Magnetic Resonance 2021, 23: 140. PMID: 34969397, PMCID: PMC8717054, DOI: 10.1186/s12968-021-00841-1.Peer-Reviewed Original ResearchCOVID-19 Vaccination–Associated Myocarditis in Adolescents
Jain SS, Steele JM, Fonseca B, Huang S, Shah S, Maskatia SA, Buddhe S, Misra N, Ramachandran P, Gaur L, Eshtehardi P, Anwar S, Kaushik N, Han F, Chaudhuri NR, Grosse-Wortmann L. COVID-19 Vaccination–Associated Myocarditis in Adolescents. Pediatrics 2021, 148: e2021053427. PMID: 34389692, DOI: 10.1542/peds.2021-053427.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceMultisystem inflammatory syndromeMyocardial tissue changesInflammatory syndromeVentricular dysfunctionMyocardial injuryTissue changesExcellent short-term outcomesMild left ventricular dysfunctionDifferent pediatric age groupsQuick clinical recoveryLeft ventricular dysfunctionResolution of symptomsRetrospective multicenter studyPediatric age groupShort-term outcomesShort-term prognosisMessenger RNA vaccinesLate gadolinium enhancementYears of ageLake Louise criteriaSignificant dysrhythmiasHospital courseClinical characteristicsClinical recoveryLeft atrial strain and diastolic function abnormalities in obese and type 2 diabetic adolescents and young adults
Steele JM, Urbina EM, Mazur WM, Khoury PR, Nagueh SF, Tretter JT, Alsaied T. Left atrial strain and diastolic function abnormalities in obese and type 2 diabetic adolescents and young adults. Cardiovascular Diabetology 2020, 19: 163. PMID: 33004030, PMCID: PMC7531140, DOI: 10.1186/s12933-020-01139-9.Peer-Reviewed Original ResearchConceptsConduit strain rateDiastolic function abnormalitiesLV diastolic functionDiastolic functionFunction abnormalitiesT2DM patientsYoung adultsLA volumeMultivariable analysisBooster strainLeft ventricular diastolic function abnormalitiesType 2 diabetic adolescentsType 2 diabetes mellitusMitral E/Normal LA volumePrevalence of diastolicStructurally normal heartsPrevalence of abnormalitiesSpeckle tracking measurementsAtrial strainAtrial functionDiabetes mellitusEchocardiographic measuresEjection fractionHeart failurePractice patterns of cardiovascular magnetic resonance use in the diagnosis of pediatric myocarditis: A survey-based study
Jacobs H, Soslow J, Cornicelli M, Merves S, Garg R, Patel M, Agarwal A, Misra N, DiLorenzo M, Campbell M, Steele J, Co-Vu J, Robinson J, Lee S, Johnson J. Practice patterns of cardiovascular magnetic resonance use in the diagnosis of pediatric myocarditis: A survey-based study. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 101091. PMID: 39270799, DOI: 10.1016/j.jocmr.2024.101091.Peer-Reviewed Original ResearchLake Louise criteriaDiagnosis of myocarditisCardiovascular magnetic resonancePractice patternsEvaluate clinical practice patternsCardiovascular magnetic resonance evaluationClinical cardiovascular magnetic resonanceNon-invasive cardiac imagingSuspicion of myocarditisParametric mappingPediatric normative dataMagnetic resonance evaluationSpecificity of diagnosisClinical practice patternsDiagnosing myocarditisPediatric myocarditisNormative dataResearch Electronic Data CapturePediatric centersPediatric populationMyocardial diseaseMyocarditisElectronic Data CaptureCMR imagesDiagnostic uncertaintyTricuspid valve flow measurement using a deep learning framework for automated valve‐tracking 2D phase contrast
Lamy J, Gonzales R, Xiang J, Seemann F, Huber S, Steele J, Wieben O, Heiberg E, Peters D. Tricuspid valve flow measurement using a deep learning framework for automated valve‐tracking 2D phase contrast. Magnetic Resonance In Medicine 2024, 92: 1838-1850. PMID: 38817154, PMCID: PMC11341256, DOI: 10.1002/mrm.30163.Peer-Reviewed Original ResearchStroke volumeHealthy subjectsLong-axis cine imagesTricuspid valve planeTricuspid regurgitation velocityDiastolic function evaluationVentricular stroke volumePhase contrastSystolic excursionRegurgitation velocityTricuspid valveTrace regurgitationDiastolic flowCine imagesTricuspidClinical challengeCardiovascular MRValve planeValvular planeAcquisition planeHigh-velocity jetPatientsTraining deep learning networksPlanimetryDeep learning frameworkCardiac manifestations and outcomes of COVID-19 vaccine-associated myocarditis in the young in the USA: longitudinal results from the Myocarditis After COVID Vaccination (MACiV) multicenter study
eClinicalMedicine, Volume 76, 2024, 102809, ISSN 2589-5370, https://doi.org/10.1016/j.eclinm.2024.102809. (https://www.sciencedirect.com/science/article/pii/S2589537024003882)Peer-Reviewed Original ResearchCardiac MRI Predictors of Arrhythmic Sudden Cardiac Events in Patients With Fontan Circulation.
Wolfe NK, Schiff MD, Olivieri LJ, Christopher AB, Fogel M, Slesnick TC, Krishnamurthy R, Muthurangu V, Dorfman AL, Lam CZ, Weigand J, Robinson JD, Rathod RH, Alsaied T, FORCE Investigators. Cardiac MRI Predictors of Arrhythmic Sudden Cardiac Events in Patients With Fontan Circulation. J Am Coll Cardiol 2024 PMID: 39453360, DOI: 10.1016/j.jacc.2024.08.063.Peer-Reviewed Original Research
2024
Characterization and Z-score Calculation of Cardiac MRI parameters in patients after the Fontan operation. A Fontan Outcome Registry using CMR Examinations (FORCE) study.
Alsaied T, Li R, Christopher A, Fogel M, Slesnick TC, Krishnamurthy R, Muthurangu V, Dorfman AL, Lam CZ, Weigand J, Jeong JH, Robinson JD, Olivieri LJ, Rathod RH, FORCE Investigators. Characterization and Z-score Calculation of Cardiac MRI parameters in patients after the Fontan operation. A Fontan Outcome Registry using CMR Examinations (FORCE) study. J Cardiovasc Magn Reson 2024, 101113. PMID: 39442671, DOI: 10.1016/j.jocmr.2024.101113.Peer-Reviewed Original ResearchLongitudinal Evaluation of Atrial Function in Patients with Tetralogy of Fallot
Ittleman B, Tretter J, Bader A, Mcollum S, Shabanova V, Steele J. Longitudinal Evaluation of Atrial Function in Patients with Tetralogy of Fallot. Pediatric Cardiology 2024, 1-9. PMID: 38849600, DOI: 10.1007/s00246-024-03503-y.Peer-Reviewed Original ResearchRepaired tetralogy of FallotPulmonary valve replacementTetralogy of FallotReservoir strain rateDiastolic functionAtrial functionTiming of pulmonary valve replacementLeft ventricular (LV) diastolic functionAssessment of left ventricular (LV) diastolic functionEvaluation of atrial functionRight ventricular systolic functionAssessment of diastolic functionFour-chamber viewVentricular systolic functionVentricular diastolic functionSustained ventricular tachyarrhythmiasRight atrial reservoirBiatrial functionRepaired tetralogyNon-invasive assessmentMedian ageSystolic functionValve replacementCMR examinationAtrial sizeThoracic aortic aneurysm in an adolescent with intraoperative discovery of contained rupture: a case report.
Lee ME, Boules H, Steele J, Asnes J, Assi R. Thoracic aortic aneurysm in an adolescent with intraoperative discovery of contained rupture: a case report. AME Case Rep 2024, 8: 36. PMID: 38711883, DOI: 10.21037/acr-23-163.Peer-Reviewed Case Reports and Technical Notes
2023
Longitudinal Assessment of Left Ventricular Function in Patients with Myopericarditis After mRNA COVID-19 Vaccination
NV B, McCollum S, Faherty E, Steele J, Karnik R. Longitudinal Assessment of Left Ventricular Function in Patients with Myopericarditis After mRNA COVID-19 Vaccination. Pediatric Cardiology 2023, 45: 1524-1532. PMID: 37294336, PMCID: PMC10251331, DOI: 10.1007/s00246-023-03200-2.Peer-Reviewed Original ResearchLeft ventricular longitudinal strainMRNA COVID-19 vaccinationCOVID-19 vaccinationSubclinical myocardial injuryEjection fractionFractional shorteningInitial presentationMyocardial injurySingle-center reviewMedian ejection fractionLeft ventricular functionVentricular longitudinal strainTime 0Area-length methodWilcoxon signed-rank testAcute illnessDiastolic functionVentricular functionDiastolic parametersLV functionRisk stratificationMyocardial recoveryTissue DopplerSigned-rank testMyopericarditisLeft ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy
Frye R, Ittleman B, Shabanova V, Sugeng L, Steele J, Ferdman D, Karnik R. Left ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy. Progress In Pediatric Cardiology 2023, 69: 101636. DOI: 10.1016/j.ppedcard.2023.101636.Peer-Reviewed Original ResearchBicuspid aortic valveLeft ventricular strainVentricular strainGlobal longitudinal strainGlobal circumferential strainAortic valvePediatric patientsEjection fractionLeft ventricle global longitudinal strainLeft ventricular global longitudinal strainBackground Bicuspid aortic valveVentricle global longitudinal strainSingle-center retrospective studyVentricular global longitudinal strainCommon congenital cardiac defectLongitudinal strainCircumferential strainAortic valve replacementNormal ejection fractionPrior cardiac interventionCongenital cardiac defectsYears of agePotential early markerLeft ventricular myocardiumSignificant differencesLeft ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy
Richard Emmett Frye, Benjamin Ittleman, Veronika Shabanova, Lissa Sugeng, Jeremy Steele, Dina Ferdman, Ruchika Karnik, Left ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy, Progress in Pediatric Cardiology, Volume 69, 2023, 101636, ISSN 1058-9813, https://doi.org/10.1016/j.ppedcard.2023.101636.Peer-Reviewed Original Research
2022
Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination
Pareek M, Steele J, Asnes J, Baldassarre L, Casale L, Desai N, Elder R, Faherty E, Ferguson I, Fishman R, Ghazizadeh Z, Glick L, Hall E, Khera R, Kokkinidis D, Kwan J, O'Marr J, Schussheim A, Tuohy E, Wang Y, Spatz E, Jacoby D, Miller E. Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination. JACC Cardiovascular Imaging 2022, 15: 2002-2005. PMID: 36357140, PMCID: PMC9094612, DOI: 10.1016/j.jcmg.2022.03.026.Peer-Reviewed Case Reports and Technical Notes
2021
Robotic mitral valve repair in a patient with cardiac dextroversion
Bourdillon A, Elder R, Lalonde M, Steele J, Gruber PJ, Geirsson A. Robotic mitral valve repair in a patient with cardiac dextroversion. JTCVS Techniques 2021, 11: 12-16. PMID: 35169722, PMCID: PMC8828793, DOI: 10.1016/j.xjtc.2021.10.031.Peer-Reviewed Case Reports and Technical NotesChallenges of Diagnosing Viral Myocarditis in Adolescents in the Era of COVID‐19 and MIS‐C
Shah HP, Frye R, Chang S, Faherty E, Steele J, Karnik R. Challenges of Diagnosing Viral Myocarditis in Adolescents in the Era of COVID‐19 and MIS‐C. Case Reports In Pediatrics 2021, 2021: 4797498. PMID: 34616578, PMCID: PMC8490073, DOI: 10.1155/2021/4797498.Peer-Reviewed Case Reports and Technical NotesPediatric myocarditisElevated inflammatory markersMultisystem inflammatory syndromeShortness of breathDiagnosis of myocarditisSudden cardiac deathCOVID-19Electrocardiogram findingsInflammatory markersInflammatory syndromeChest tightnessCardiac deathMale presentingAnnual incidenceClinical presentationD-dimerViral myocarditisMyocardial injuryClinical conundrumSubclinical presentationMyocarditisRare diseaseClinical experienceTrue prevalenceCurrent Covid-19 pandemic eraA 13-Year-Old With Fever and Chest Pain
Soma G, Simmons MA, Canarie MF, Karnik R, Steele J, Tiyyagura G, Asnes J. A 13-Year-Old With Fever and Chest Pain. Pediatrics 2021, 148: e2021050960. PMID: 34344802, DOI: 10.1542/peds.2021-050960.Peer-Reviewed Case Reports and Technical Notes