2001
Human GABAB receptor 1 gene: Eight novel sequence variants
Hisama F, Gruen J, Choi J, Huseinovic M, Grigorenko E, Pauls D, Mattson R, Gelernter J, Wood F, Goei V. Human GABAB receptor 1 gene: Eight novel sequence variants. Human Mutation 2001, 17: 349-350. PMID: 11295833, DOI: 10.1002/humu.34.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 6DNA Mutational AnalysisDNA PrimersExonsGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansIntronsMental DisordersMutationMutation, MissensePolymorphism, GeneticPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalReceptors, GABA-BUnited StatesConceptsNeurobehavioral disordersPrincipal inhibitory neurotransmitterHuman leukocyte antigen (HLA) regionInhibitory neurotransmitterPharmacogenetic studiesGene mutationsAntigen regionIntron variantsMissense mutationsDistinct mutationsDisordersLinkage studiesReceptor mapsAmerican populationGABBR1MutationsSusceptibility regionsEpilepsyCandidate genesDNA variantsGABANeurotransmittersSchizophreniaBrain
1998
Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization
Goei V, Choi J, Ahn J, Bowlus C, Raha-Chowdhury R, Gruen J. Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization. Biological Psychiatry 1998, 44: 659-666. PMID: 9798068, DOI: 10.1016/s0006-3223(98)00244-3.Peer-Reviewed Original ResearchConceptsGenomic organizationGenetic lociGenomic DNA clonesPotential positional candidate genesPositional candidate genesComplementary DNA cloningFull-length cDNAOpen reading frameHuman chromosome 6Northern blot hybridizationGenomic locationTelomeric sitesChromosomal locationHybridization selectionDNA clonesHuman genesReading frameDNA cloningGenomic DNACentromeric genesChromosome 6Sequence analysisGenesAmino acidsGABAB receptor gene
1991
Differential expression of novel Gsα signal transduction protein cDNA species
Swaroop A, Agarwal N, Gruen J, Bick D, Weissman S. Differential expression of novel Gsα signal transduction protein cDNA species. Nucleic Acids Research 1991, 19: 4725-4729. PMID: 1716359, PMCID: PMC328715, DOI: 10.1093/nar/19.17.4725.Peer-Reviewed Original ResearchConceptsCDNA speciesAlpha speciesDifferential expressionSignal transduction proteinsAlpha cDNA cloneTransduction proteinsHeterotrimeric complexCDNA clonesAlternative promotersNovel exonsAlternate splicingAUG codonHuman adult retinaMembrane receptorsGs alphaNovel signalSpeciesSpecific oligonucleotide probesOligonucleotide probesSitu hybridizationExon 2Total RNASpecific primersMolecular heterogeneityAdult retina