2012
Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability
Cope N, Eicher JD, Meng H, Gibson CJ, Hager K, Lacadie C, Fulbright RK, Constable RT, Page GP, Gruen JR. Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. NeuroImage 2012, 63: 148-156. PMID: 22750057, PMCID: PMC3518451, DOI: 10.1016/j.neuroimage.2012.06.037.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingChildChromosomes, Human, Pair 6DyslexiaFemaleGenetic VariationHumansMaleNerve Tissue ProteinsReading
2001
Peaks of Linkage Are Localized by a BAC/PAC Contig of the 6p Reading Disability Locus
Ahn J, Won T, Zia A, Reutter H, Kaplan D, Sparks R, Gruen J. Peaks of Linkage Are Localized by a BAC/PAC Contig of the 6p Reading Disability Locus. Genomics 2001, 78: 19-29. PMID: 11707069, DOI: 10.1006/geno.2001.6645.Peer-Reviewed Original ResearchConceptsBacterial artificial chromosomeBAC/PAC contigHigh-resolution genetic studiesEntire chromosome 6Intermarker distanceArtificial chromosome contigPhysical mapping dataPeak of linkageSuccinic semialdehyde dehydrogenaseUncharacterized genesGenetic boundariesSequence tagsShort tandem repeatsArtificial chromosomesMarker orderClone contigNew contigPhysical mapGenetic lociLinkage peakCandidate genesPAC contigSemialdehyde dehydrogenaseContigsChromosome 6Human GABAB receptor 1 gene: Eight novel sequence variants
Hisama F, Gruen J, Choi J, Huseinovic M, Grigorenko E, Pauls D, Mattson R, Gelernter J, Wood F, Goei V. Human GABAB receptor 1 gene: Eight novel sequence variants. Human Mutation 2001, 17: 349-350. PMID: 11295833, DOI: 10.1002/humu.34.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 6DNA Mutational AnalysisDNA PrimersExonsGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansIntronsMental DisordersMutationMutation, MissensePolymorphism, GeneticPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalReceptors, GABA-BUnited StatesConceptsNeurobehavioral disordersPrincipal inhibitory neurotransmitterHuman leukocyte antigen (HLA) regionInhibitory neurotransmitterPharmacogenetic studiesGene mutationsAntigen regionIntron variantsMissense mutationsDistinct mutationsDisordersLinkage studiesReceptor mapsAmerican populationGABBR1MutationsSusceptibility regionsEpilepsyCandidate genesDNA variantsGABANeurotransmittersSchizophreniaBrain
1999
The genomic organization of the histone clusters on human 6p21.3
Ahn J, Gruen J. The genomic organization of the histone clusters on human 6p21.3. Mammalian Genome 1999, 10: 768-770. PMID: 10384058, DOI: 10.1007/s003359901089.Peer-Reviewed Original ResearchAnimalsBase SequenceChromosomes, Human, Pair 6DNA PrimersHistonesHumansMultigene FamilyPhysical Chromosome Mapping
1998
Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization
Goei V, Choi J, Ahn J, Bowlus C, Raha-Chowdhury R, Gruen J. Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization. Biological Psychiatry 1998, 44: 659-666. PMID: 9798068, DOI: 10.1016/s0006-3223(98)00244-3.Peer-Reviewed Original ResearchConceptsGenomic organizationGenetic lociGenomic DNA clonesPotential positional candidate genesPositional candidate genesComplementary DNA cloningFull-length cDNAOpen reading frameHuman chromosome 6Northern blot hybridizationGenomic locationTelomeric sitesChromosomal locationHybridization selectionDNA clonesHuman genesReading frameDNA cloningGenomic DNACentromeric genesChromosome 6Sequence analysisGenesAmino acidsGABAB receptor gene
1992
Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE)
Gruen J, Goei V, Summers K, Capossela A, Powell L, Halliday J, Zoghbi H, Shukla H, Weissman S. Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE). Genomics 1992, 14: 232-240. PMID: 1427838, DOI: 10.1016/s0888-7543(05)80211-3.Peer-Reviewed Original ResearchConceptsPhysical mapGenomic DNACell linesRadiation hybrid cell linesHigh-resolution physical mapLong-range physical mapGenetic mapping studiesHuman genomic DNAPulsed-field gel electrophoresisHybrid cell linesRestriction fragment banding patternsMajor histocompatibility complex regionGenetic mappingMajor histocompatibility complex (MHC) class I regionHuman genomeHLA-F geneBanding patternsClass I regionGenesDisequilibrium analysisGel electrophoresisMapping studiesDNAI regionClass I