2022
Discovery of 42 genome-wide significant loci associated with dyslexia
Doust C, Fontanillas P, Eising E, Gordon SD, Wang Z, Alagöz G, Molz B, Pourcain B, Francks C, Marioni R, Zhao J, Paracchini S, Talcott J, Monaco A, Stein J, Gruen J, Olson R, Willcutt E, DeFries J, Pennington B, Smith S, Wright M, Martin N, Auton A, Bates T, Fisher S, Luciano M. Discovery of 42 genome-wide significant loci associated with dyslexia. Nature Genetics 2022, 54: 1621-1629. PMID: 36266505, PMCID: PMC9649434, DOI: 10.1038/s41588-022-01192-y.Peer-Reviewed Original ResearchConceptsGenome-wide significant lociSignificant lociIndependent genome-wide significant lociWide association studyGenetic covarianceAssociation studiesGenetic markersLociGenetic etiologyEuropean ancestryTraitsPolygenic scoresCrucial life skillGenesHeritabilityIndependent cohortAncestryFamily studiesDiscovery
2016
Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders
Truong DT, Shriberg LD, Smith SD, Chapman KL, Scheer-Cohen AR, DeMille MM, Adams AK, Nato AQ, Wijsman EM, Eicher JD, Gruen JR. Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders. Human Genetics 2016, 135: 1329-1341. PMID: 27535846, PMCID: PMC5065602, DOI: 10.1007/s00439-016-1717-z.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolChromosome MappingChromosomes, Human, Pair 13Drosophila ProteinsDyslexiaFemaleGenetic LinkageGenetic Predisposition to DiseaseGenotypeHumansLanguage DisordersLod ScoreMaleMembrane ProteinsMiddle AgedNuclear ProteinsPedigreeQuantitative Trait LociReadingSpeech DisordersWritingConceptsNonword repetitionSpecific language impairmentCognitive processesLanguage impairmentAuditory processingVerbal developmentMotor planningPerson's abilityRobust endophenotypesMultigenerational familiesLanguage traitsRepetitionDisordersGenome-wide linkage scanSpellingVariance component linkage analysisCausal genetic factorsMultipoint variance component linkage analysisMemoryEndophenotypesSpeechChromosome 13qFuture studiesPresent studyDeficitsExecutive Functions Contribute Uniquely to Reading Competence in Minority Youth
Jacobson LA, Koriakin T, Lipkin P, Boada R, Frijters JC, Lovett MW, Hill D, Willcutt E, Gottwald S, Wolf M, Bosson-Heenan J, Gruen JR, Mahone EM. Executive Functions Contribute Uniquely to Reading Competence in Minority Youth. Journal Of Learning Disabilities 2016, 50: 422-433. PMID: 26755569, PMCID: PMC5960349, DOI: 10.1177/0022219415618501.Peer-Reviewed Original ResearchConceptsExecutive functionAttentional switchingMinority youthDomain-general processesComponents of readingInformation processing speedHierarchical linear regressionWord readingExecutive skillsAssessment of individualsCompetent readingReading interventionLanguage skillsContextual wordsProcessing speedFluencyUnique contributionComprehensionSkillsYouthMinority backgroundsReadingEthnic minority groupsCaucasian samplesCompetence
2012
Prenatal Exposure to Nicotine and Impaired Reading Performance
Cho K, Frijters JC, Zhang H, Miller LL, Gruen JR. Prenatal Exposure to Nicotine and Impaired Reading Performance. The Journal Of Pediatrics 2012, 162: 713-718.e2. PMID: 23122624, PMCID: PMC3577994, DOI: 10.1016/j.jpeds.2012.09.041.Peer-Reviewed Original ResearchConceptsSchool-aged childrenPrenatal nicotine exposureSkill outcomesAge childrenLongitudinal studyPotential mediatorsNicotine exposureSkills of childrenPhonological deficitPrenatal exposureRisk of underperformanceReading performanceSingle wordsAvon Longitudinal StudyLongitudinal samplePoor performanceLarge associationsNegative associationChildrenAreas of speedParentsSpellingFluencyNicotineComprehensionVariants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability
Cope N, Eicher JD, Meng H, Gibson CJ, Hager K, Lacadie C, Fulbright RK, Constable RT, Page GP, Gruen JR. Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. NeuroImage 2012, 63: 148-156. PMID: 22750057, PMCID: PMC3518451, DOI: 10.1016/j.neuroimage.2012.06.037.Peer-Reviewed Original Research