A conceptual framework for the molecular pathogenesis of progressive kidney disease
Schnaper HW, Hubchak SC, Runyan CE, Browne JA, Finer G, Liu X, Hayashida T. A conceptual framework for the molecular pathogenesis of progressive kidney disease. Pediatric Nephrology 2010, 25: 2223-2230. PMID: 20352456, PMCID: PMC5558437, DOI: 10.1007/s00467-010-1503-4.Peer-Reviewed Original ResearchConceptsKidney diseaseProgressive nephron lossChronic kidney diseaseProgressive kidney diseaseRole of cytokinesProgressive glomerular diseaseNephron lossGlomerular diseaseClinical conditionsCytokine effectsClinical practiceMolecular pathogenesisDiseasePathogenesisCellular dysfunctionAdaptive physiological responsesPhysiological factorsCellular responsesRepairSubsequent cyclesPhysiological responsesTissue-specific cellular responsesProteinuriaDysfunctionCytokines