2008
PIPERACILLIN/TAZOBACTAM PLUS AMIKACIN VERSUS CARBAPENEM MONOTHERAPY AS EMPIRICAL TREATMENT OF FEBRILE NEUTROPENIA IN CHILDHOOD HEMATOLOGICAL MALIGNANCIES
Yildirim I, Aytac S, Ceyhan M, Cetin M, Tuncer M, Cengiz AB, Secmeer G, Yetgin S. PIPERACILLIN/TAZOBACTAM PLUS AMIKACIN VERSUS CARBAPENEM MONOTHERAPY AS EMPIRICAL TREATMENT OF FEBRILE NEUTROPENIA IN CHILDHOOD HEMATOLOGICAL MALIGNANCIES. Pediatric Hematology And Oncology 2008, 25: 291-299. PMID: 18484473, DOI: 10.1080/08880010802016847.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmikacinAnti-Bacterial AgentsBacteriaBacterial InfectionsCarbapenemsChildChild, PreschoolDrug Therapy, CombinationEnzyme InhibitorsFemaleHumansLeukemia, Myeloid, AcuteMaleNeutropeniaPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug CombinationPrecursor Cell Lymphoblastic Leukemia-LymphomaConceptsFebrile neutropenic episodesDuration of feverPiperacillin/tazobactamCarbapenem monotherapyNeutropenic episodesHematological malignanciesFebrile neutropeniaEmpirical treatmentInitial empirical regimenInfection-related mortalityPediatric hematological malignanciesChildhood hematological malignanciesAcute lymphoblastic leukemiaAcute myeloblastic leukemiaAmikacin combinationEmpirical regimenPTA groupCarbapenem groupLymphoblastic leukemiaTreatment modificationAntimicrobial therapyClinical trialsTreatment successAdditional antibioticsCommon cause
2007
Role of Procalcitonin and CRP in Differentiating a Stable From a Deteriorating Clinical Course in Pediatric Febrile Neutropenia
Secmeer G, Devrim I, Kara A, Ceyhan M, Cengiz B, Kutluk T, Buyukpamukcu M, Yetgin S, Tuncer M, Uludag AK, Tezer H, Yildirim I. Role of Procalcitonin and CRP in Differentiating a Stable From a Deteriorating Clinical Course in Pediatric Febrile Neutropenia. Journal Of Pediatric Hematology/Oncology 2007, 29: 107-111. PMID: 17279007, DOI: 10.1097/mph.0b013e3180320b5b.Peer-Reviewed Original ResearchConceptsNeutropenic fever patientsC-reactive proteinIntensive chemotherapyNeutropenic feverPCT concentrationsErythrocyte sedimentation rate levelsHacettepe University Ihsan Doğramaci Children's HospitalHours of onsetRole of procalcitoninValue of procalcitoninErythrocyte sedimentation ratePediatric febrile neutropeniaFebrile neutropeniaInflammation parametersControl patientsCRP levelsFebrile episodesOccult infectionUnderlying diseaseAntibiotic therapyClinical courseChildren's HospitalProspective studyTherapy modificationLeukocyte count