2009
Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell disease
Pashankar FD, Carbonella J, Bazzy‐Asaad A, Friedman A. Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell disease. British Journal Of Haematology 2009, 144: 736-741. PMID: 19055665, DOI: 10.1111/j.1365-2141.2008.07501.x.Peer-Reviewed Original ResearchConceptsTricuspid regurgitant jet velocityElevated pulmonary artery pressurePulmonary artery pressureSickle cell diseaseArtery pressureCell diseaseHigher tricuspid regurgitant jet velocityObstructive sleep apneaRegurgitant jet velocityRight ventricular pressureLowest oxygen saturationBorderline elevationCardiopulmonary evaluationInitial echocardiogramRepeat echocardiogramPulmonary hypertensionLower hemoglobinSleep apneaPersistent elevationRisk factorsVentricular pressureIntrapatient variabilityOxygen saturationEchocardiogramPatients
2008
Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure
Nakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A. Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure. Pediatrics 2008, 122: e634-e642. PMID: 18762497, PMCID: PMC5117807, DOI: 10.1542/peds.2008-0154.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep-disordered breathingSympathetic nervous system activityPositive airway pressureNervous system activityWhole-body insulin sensitivityMetabolic syndromeAirway pressureLeptin levelsInsulin sensitivitySystem activityExact testContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentC-reactive protein levelsOral glucose tolerance testGlucose tolerance testRole of leptinBMI z-scoreFisher's exact testOvernight polysomnographyBreathing groupMetabolic derangementsInsulin resistanceSleep QuestionnairePrevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease
Pashankar FD, Carbonella J, Bazzy-Asaad A, Friedman A. Prevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease. Pediatrics 2008, 121: 777-782. PMID: 18381543, DOI: 10.1542/peds.2007-0730.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionAnemia, Sickle CellChildChild, PreschoolCohort StudiesComorbidityFemaleFollow-Up StudiesHumansHypertension, PulmonaryMaleMass ScreeningPrevalenceProspective StudiesPulmonary Wedge PressureRisk AssessmentSeverity of Illness IndexSex DistributionSurvival AnalysisTricuspid Valve InsufficiencyUltrasonography, Doppler, TranscranialConceptsTricuspid regurgitant jet velocityElevated pulmonary artery pressureElevated tricuspid regurgitant jet velocityPulmonary artery pressureRegurgitant jet velocityTranscranial Doppler examinationArtery pressurePulmonary hypertensionDoppler examinationSickle cell diseaseRisk factorsCell diseaseExact testPeak tricuspid regurgitant jet velocityPulmonary artery systolic pressureHigh pulmonary artery pressureComprehensive clinic visitModerate pulmonary hypertensionRight outflow obstructionAcute chest syndromeMild pulmonary hypertensionPercent of patientsChronic blood transfusionsHigher platelet countsLowest oxygen saturation