2016
Regulation of DNA Repair by Hypoxia
Lu Y, Glazer P. Regulation of DNA Repair by Hypoxia. 2016, 169-188. DOI: 10.1142/9789813147324_0007.Peer-Reviewed Original Research
2011
Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter
Lu Y, Chu A, Turker MS, Glazer PM. Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter. Molecular And Cellular Biology 2011, 31: 3339-3350. PMID: 21670155, PMCID: PMC3147797, DOI: 10.1128/mcb.01121-10.Peer-Reviewed Original ResearchConceptsBRCA1 promoterH3K9 acetylationLysine-specific histone demethylase LSD1BRCA1 tumor suppressorShort-term repressionDNA methylation inhibitorHistone demethylase LSD1Hypoxic stressTreatment of cellsH3K9 methylationRepressive modificationsGenome instabilityHistone modificationsEpigenetic regulationEpigenetic modificationsDemethylase LSD1Methylation inhibitorTranscriptional levelHistone deacetylase inhibitorsTumor suppressorPromoterHPRT geneMethylationSporadic cancersBRCA1 expression
2010
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130
Hegan DC, Lu Y, Stachelek GC, Crosby ME, Bindra RS, Glazer PM. Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 2201-2206. PMID: 20133863, PMCID: PMC2836641, DOI: 10.1073/pnas.0904783107.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorColonic NeoplasmsCrk-Associated Substrate ProteinDNA RepairDown-RegulationE2F4 Transcription FactorEnzyme InhibitorsGenes, BRCA1HumansPhenanthrenesPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesPromoter Regions, GeneticRad51 RecombinaseRadiation-Sensitizing AgentsRNA, Small InterferingConceptsHomology-dependent repairBase excision repair factorsExcision repair factorsPARP inhibitionRole of PARPPARP inhibitorsRepair factorsExpression of BRCA1DNA repairDNA breaksHypoxic cancer cellsRAD51SiRNA knockdownDNA damagePARP-1P130 expressionCancer therapyP130Cancer cellsPARPRad51 promoterHPV E7BRCA1E7 expressionSiRNAs
2004
Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells.
Lu Y, Zi X, Pollak M. Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. International Journal Of Cancer. Journal International Du Cancer 2004, 108: 334-41. PMID: 14648698, DOI: 10.1002/ijc.11445.Peer-Reviewed Original ResearchOverexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells.
Lu Y, Zi X, Zhao Y, Pollak M. Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells. Biochemical And Biophysical Research Communications 2004, 313: 709-15. PMID: 14697248.Peer-Reviewed Original Research
2002
Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells.
Camirand A, Lu Y, Pollak M. Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells. Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research 2002, 8: BR521-6. PMID: 12503030.Peer-Reviewed Original Research
2001
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).
Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). Journal Of The National Cancer Institute 2001, 93: 1852-7. PMID: 11752009.Peer-Reviewed Original Research