2017
Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer
Matsumoto A, Arcaroli J, Chen Y, Gasparetto M, Neumeister V, Thompson DC, Singh S, Smith C, Messersmith W, Vasiliou V. Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer. British Journal Of Cancer 2017, 117: 1537-1543. PMID: 28881356, PMCID: PMC5680456, DOI: 10.1038/bjc.2017.304.Peer-Reviewed Original ResearchConceptsCRC markersTumor tissueNormal tissuesCell linesHuman CRC explantsCRC cell linesColorectal cancer markersAldehyde dehydrogenase 1A1CRC explantsImmunohistological biomarkersColorectal cancerCRC biomarkersImmunohistological markersTissue microarraySolid tumorsLow expressionMicroarray findingsGenetic alterationsALDH isozymesCell populationsALDH1A1CRCMRNA analysisCancer markersMarkers
2011
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer
Chen Y, Orlicky DJ, Matsumoto A, Singh S, Thompson DC, Vasiliou V. Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. Biochemical And Biophysical Research Communications 2011, 405: 173-179. PMID: 21216231, PMCID: PMC3112362, DOI: 10.1016/j.bbrc.2011.01.002.Peer-Reviewed Original ResearchConceptsHuman colon cancerColon cancerPotential biomarkersLipid peroxidationHigher expression scoresHuman cancersAldehyde dehydrogenase 1B1Cancer stem cellsColonic cancer specimensHuman colonic adenocarcinomaColonic adenocarcinomaImmunohistochemical expressionCancer specimensActivity of ALDHTumor tissueExpression scoreHuman adenocarcinomasTissue arraysAdenocarcinomaALDH activityCancerALDH1A1ALDH isozymesCancerous tissuesStem cells
2009
Corneal aldehyde dehydrogenases: Multiple functions and novel nuclear localization
Stagos D, Chen Y, Cantore M, Jester JV, Vasiliou V. Corneal aldehyde dehydrogenases: Multiple functions and novel nuclear localization. Brain Research Bulletin 2009, 81: 211-218. PMID: 19720116, PMCID: PMC3025408, DOI: 10.1016/j.brainresbull.2009.08.017.Peer-Reviewed Original ResearchConceptsException of rabbitsCorneal epitheliumOcular tissuesMouse corneaProtective roleUVR exposureCorneaMessenger levelsNuclear presenceOxidative damageCorneal crystallinsSubstantial evidenceNovel nuclear localizationALDH3A1Rabbit keratocytesReactive aldehydesCell cycle regulationAntioxidant activityGene expressionALDHMost mammalsCycle regulationExogenous aldehydesNuclear localizationALDH1A1