2019
Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response
Sahraei M, Chaube B, Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, García-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernández-Hernando C, Suárez Y. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response. Journal Of Clinical Investigation 2019, 129: 5518-5536. PMID: 31710308, PMCID: PMC6877327, DOI: 10.1172/jci127125.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesMiR-21 expressionTumor growthMiR-21Immune responseCytotoxic T cell responsesC motif chemokine 10Antitumor immune responseT cell responsesAntitumoral immune responseTumor immune infiltratesInduction of cytokinesPotential therapeutic implicationsMiR-21 inhibitionStages of carcinogenesisAngiostatic phenotypeTumor cell deathIL-12Immune infiltratesTherapeutic implicationsSolid tumorsTumor neovascularizationTumor progressionTumor microenvironmentTumor pathogenesis
2007
Alloimmunity to Human Endothelial Cells Derived from Cord Blood Progenitors
Suárez Y, Shepherd BR, Rao DA, Pober JS. Alloimmunity to Human Endothelial Cells Derived from Cord Blood Progenitors. The Journal Of Immunology 2007, 179: 7488-7496. PMID: 18025193, DOI: 10.4049/jimmunol.179.11.7488.Peer-Reviewed Original ResearchConceptsCell-derived endothelial cellsEndothelial progenitor cellsCord blood endothelial progenitor cellsBlood endothelial progenitor cellsEndothelial cellsCord blood progenitorsExpression of proteinsMemory T cell responsesHuman endothelial cellsT cell responsesProgenitor cellsBlood progenitorsOrgan repairRegenerative medicineAllogeneic responseAdhesion moleculesTissue engineeringTissue sourcesMHC moleculesCell responsesSuch cellsCellsSame donorAlloimmunityVitro