2020
miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression
Benito-Vicente A, Uribe KB, Rotllan N, Ramírez CM, Jebari-Benslaiman S, Goedeke L, Canfrán-Duque A, Galicia-García U, De Urturi D, Aspichueta P, Suárez Y, Fernández-Hernando C, Martín C. miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression. International Journal Of Molecular Sciences 2020, 21: 8675. PMID: 33212990, PMCID: PMC7698485, DOI: 10.3390/ijms21228675.Peer-Reviewed Original ResearchConceptsInsulin resistanceInsulin receptor substrate-1Type 2 diabetes mellitusHepatic insulin resistanceInsulin receptorInsulin receptor expressionImplication of microRNAsDiabetes mellitusHeart failureCardiometabolic pathologiesInsulin sensitivityReceptor expressionINSR expressionReceptor substrate-1Human hepatoma cellsHepatic tissueLipid metabolismObesityInsulinHigh expressionMiR-27Hepatoma cellsSubstrate-1Novel roleLiver
2004
Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin
Suárez Y, Fernández C, Gómez-Coronado D, Ferruelo AJ, Dávalos A, Martínez-Botas J, Lasunción MA. Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. Cardiovascular Research 2004, 64: 346-355. PMID: 15485695, DOI: 10.1016/j.cardiores.2004.06.024.Peer-Reviewed Original ResearchConceptsLDL receptor activityLow-density lipoproteinReceptor activityLow density lipoprotein receptor activityPlasma LDL cholesterol levelsLDL cholesterol levelsLipoprotein receptor activityEstrogen receptor modulatorsBreast cancer therapyReceptor mRNA levelsLDL receptor mRNA levelsLDL receptor expressionCholesterol-lowering activityDose-dependent mannerHigh LDL concentrationsHypolipidemic effectsMOLT-4 cellsCholesterol levelsReceptor expressionReceptor modulatorsEstrogen receptorTamoxifenLDL concentrationLDL uptakeLDL receptor