2007
Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function
Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, Bokoch GM. Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. Journal Of Leukocyte Biology 2007, 81: 1127-1136. PMID: 17227822, DOI: 10.1189/jlb.0406251.Peer-Reviewed Original ResearchConceptsProtein kinase AEndogenous P-Rex1P-Rex1Exchange factorBetagamma subunitsCAMP-dependent protein kinase ACell adhesionG protein betagamma subunitsHeterotrimeric G proteinsActivation of PKARac-specific guanineG protein-coupled receptorsProtein betagamma subunitsNeutrophil chemoattractant receptorsProtein-coupled receptorsTyrosine kinase activityDependent RacExtracellular stimuliSpatial regulationKinase AKinase activityF-actinG proteinsImportant regulatorRac2 activation
2005
P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils
Dong X, Mo Z, Bokoch G, Guo C, Li Z, Wu D. P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils. Current Biology 2005, 15: 1874-1879. PMID: 16243036, DOI: 10.1016/j.cub.2005.09.014.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCaseinsCell LineChemotaxisCloning, MolecularEnzyme ActivationGene TargetingGuanine Nucleotide Exchange FactorsHumansImmunoprecipitationMiceMice, KnockoutNeuropeptidesNeutrophilsN-Formylmethionine Leucyl-PhenylalanineProtein TransportRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSuperoxidesConceptsP-Rex1Exchange factorGuanine nucleotide exchange factorsNucleotide exchange factorsRegulation of RacF-actin formationMouse neutrophilsSmall GTPasesRho familyRac activityApparent high affinityRac activatorActin formationRac1 activationRac2 activationCdc42Mouse linesRacRac2RhoAMigration rateRegulationHigh affinityLeukocyte chemoattractantsGTPases