2024
Macrophage Infusion Rescues Cisplatin (CP)-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Safirstein R, Desir G. Macrophage Infusion Rescues Cisplatin (CP)-Induced AKI. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024psy855fx. DOI: 10.1681/asn.2024psy855fx.Peer-Reviewed Original ResearchRenalase peptides reduce pancreatitis severity in mice
Kolodecik T, Guo X, Shugrue C, Guo X, Desir G, Wen L, Gorelick F. Renalase peptides reduce pancreatitis severity in mice. AJP Gastrointestinal And Liver Physiology 2024, 327: g466-g480. PMID: 39010833, PMCID: PMC11427088, DOI: 10.1152/ajpgi.00143.2024.Peer-Reviewed Original ResearchAcute pancreatitisRecombinant renalaseProsurvival propertiesSeverity of acute pancreatitisModel of acute pancreatitisAcute inflammatory injuryClinically relevant modelAnti-inflammatoryHistological tissue injuryPost-ERCPCerulein modelCerulein-inducedInitial dosePancreatitis severityPreclinical modelsImmunohistochemical markersQuantify inflammationInflammatory changesMale micePancreatitisMacrophage populationsTissue injuryCerulein pancreatitisTherapeutic effectRenalaseRenalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19
Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.Peer-Reviewed Original Research
2023
Clinical predictive value of renalase in post-ERCP pancreatitis
Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.Peer-Reviewed Original ResearchPost-ERCP pancreatitisRenalase levelsPlasma renalase levelsProspective cohort studyPotential clinical roleAcute experimental pancreatitisLongitudinal regression modelsPEP patientsPlasma renalaseCohort studyTertiary hospitalClinical roleExperimental pancreatitisRenalaseAbstractTextERCPPancreatitisFurther studiesAIMSRegression modelsAPOBEC-1 deletion enhances cisplatin-induced acute kidney injury
Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.Peer-Reviewed Original ResearchmRNA Editing via the Apobec1 Gene Promotes Recovery from AKI
Guo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.Peer-Reviewed Original ResearchRenalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms
Guo X, Chen R, Chen T, Safirstein R, Jonas E, Desir G. Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms. Journal Of The American Society Of Nephrology 2023, 34: 117-117. DOI: 10.1681/asn.20233411s1117b.Peer-Reviewed Original ResearchSa1408 PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS
Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Sa1408 PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS. Gastroenterology 2023, 164: s-384-s-385. DOI: 10.1016/s0016-5085(23)01894-2.Peer-Reviewed Original ResearchPlasma renalase levels are associated with the development of acute pancreatitis
Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, DOI: 10.1016/j.pan.2023.01.001.Peer-Reviewed Original ResearchConceptsAcute pancreatitisSevere diseasePlasma renalase levelsAcute pancreatitis patientsSevere acute pancreatitisAcute pancreatitis modelPlasma renalaseRenalase levelsSignificant morbidityPancreatitis patientsPlasma levelsHealthy controlsPancreatitis modelPancreatitisPatientsPlasma samplesRenalaseDiseaseNonparametric statistical analysisSecretory proteinsMorbidityStatistical analysisMortalityLevels
2022
Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Blanc V, Davidson N, Moeckel G, Safirstein R, Desir G. Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI. Journal Of The American Society Of Nephrology 2022, 33: 359-360. DOI: 10.1681/asn.20223311s1359e.Peer-Reviewed Original ResearchRenalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis
Guo X, Chen R, Chen T, Moeckel G, Safirstein R, Jonas E, Desir G. Renalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis. Journal Of The American Society Of Nephrology 2022, 33: 359-359. DOI: 10.1681/asn.20223311s1359d.Peer-Reviewed Original Research
2021
Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD
Guo X, Xu L, Chen T, Gorelick F, Desir G, Safirstein R. Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD. Journal Of The American Society Of Nephrology 2021, 32: 749-749. DOI: 10.1681/asn.20213210s1749c.Peer-Reviewed Original Research
2020
Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD
Guo X, Xu L, Velazquez H, Chen T, Williams R, Heller D, Safirstein R, Desir G. Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD. Journal Of The American Society Of Nephrology 2020, 31: 230-230. DOI: 10.1681/asn.20203110s1230b.Peer-Reviewed Original ResearchApobec 1 Limits Cisplatin-Induced AKI by Regulating the Disposal of Pro-Ferroptotic Lipids
Guo X, Velazquez H, Chen T, Blanc V, Davidson N, Safirstein R, Desir G. Apobec 1 Limits Cisplatin-Induced AKI by Regulating the Disposal of Pro-Ferroptotic Lipids. Journal Of The American Society Of Nephrology 2020, 31: 123-123. DOI: 10.1681/asn.20203110s1123d.Peer-Reviewed Original Research
2019
MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA
Rao V, Guo X, Chang J, Peixoto A, Testani J, Desir G. MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA. Kidney International Reports 2019, 4: s67. DOI: 10.1016/j.ekir.2019.05.180.Peer-Reviewed Original ResearchSAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY
Desir G, Chang J, Guo X, Gromisch E, Peixoto A. SAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY. Kidney International Reports 2019, 4: s84-s85. DOI: 10.1016/j.ekir.2019.05.217.Peer-Reviewed Original Research
2016
Adrenomedullin 2 activates extracellular-signal-regulated kinase in endothelial cells via a protein kinase C α-independent pathway
Guo X, Ju R, Cha C, Simons M. Adrenomedullin 2 activates extracellular-signal-regulated kinase in endothelial cells via a protein kinase C α-independent pathway. F1000Research 2016, 5: 26. DOI: 10.12688/f1000research.2420.1.Peer-Reviewed Original Research
2015
The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinoma
Hollander LL, Guo X, Salem RR, H. CH. The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinoma. Journal Of Surgical Research 2015, 197: 219-224. PMID: 25982376, DOI: 10.1016/j.jss.2014.11.002.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinase/extracellular signal-regulated kinaseProtein kinase/extracellular signal-regulated kinaseExtracellular signal-regulated kinaseSignal-regulated kinaseTotal cellular levelsAdrenomedullin 2Tumor angiogenesis factorVascular endothelial growth factor 2Microarray technologyGrowth factor 2Cellular levelNovel therapeutic targetPancreatic cancer tissuesProtein expressionFactor 2Angiogenesis factorsTherapeutic targetTumor angiogenic factorsTumor angiogenesisAngiogenic rolePotential roleWorse histologic gradePossible roleCancer tissuesPancreas cancer
2014
Renalase
Guo X, Wang L, Velazquez H, Safirstein R, Desir GV. Renalase. Current Opinion In Nephrology & Hypertension 2014, 23: 513-518. PMID: 24992568, PMCID: PMC4383282, DOI: 10.1097/mnh.0000000000000044.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsEnzymatic functionType 1 diabetesMitogen-activated protein kinase pathwayNucleotide polymorphismsProtein kinase BProtein kinase pathwayCellular actionsPlasma membraneKinase pathwayKinase BPotential therapeutic utilityCertain single nucleotide polymorphismsEnzymatic propertiesIschemic strokeImmune modulatorsRenalase geneTherapeutic utilityCytoprotective effectsClinical implicationsRenalaseConsistent associationPotential roleDiabetesCytokinesAutomated Quantitative Analysis of Tissue Microarray of 443 Patients with Colorectal Adenocarcinoma: Low Expression of Bcl-2 Predicts Poor Survival
Nicholson AD, Guo X, Sullivan CA, H. CH. Automated Quantitative Analysis of Tissue Microarray of 443 Patients with Colorectal Adenocarcinoma: Low Expression of Bcl-2 Predicts Poor Survival. Journal Of The American College Of Surgeons 2014, 219: 977-987. PMID: 25127509, DOI: 10.1016/j.jamcollsurg.2014.07.007.Peer-Reviewed Original ResearchConceptsDisease-specific survivalBcl-2 expressionColorectal cancerOverall survivalPoor disease-specific survivalCox proportional hazards modelIndependent prognostic factorSubset of patientsColorectal adenocarcinoma samplesLog-rank testBcl-2Proportional hazards modelSemi-quantitative grading methodsColorectal cancer samplesNumber of cancersPrognostic factorsT stageChemotherapy choiceClinicopathologic variablesColorectal adenocarcinomaUnivariate analysisPatient outcomesPoor survivalTissue microarrayAggressive phenotype