Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsWinifred Mak, MBBS, PhD
Assistant Professor Adjunct of Obstetrics, Gynecology & Reproductive SciencesAbout
Copy Link
Titles
Assistant Professor Adjunct of Obstetrics, Gynecology & Reproductive Sciences
Director, Early Recurrent Pregnancy Loss Program
Biography
Yale’s Early Recurrent Pregnancy Loss (RPL) Program provides cutting-edge fertility treatments to help couples overcome pregnancy loss. As the program’s director, Dr. Winifred Mak believes in the importance of consistently incorporating new research and therapies into treatment methods. “Our goal is your goal: to achieve a healthy pregnancy,” she says.
With four offices in Connecticut—Guilford, New Haven, Westport and Stamford—the program offers, “a personalized and evidence-based approach to treatment,” according to Dr. Mak. In addition to caring for patients, Dr. Mak is also an assistant professor in the Obstetrics, Gynecology and Reproductive Sciences Department at Yale School of Medicine. She treats the full range of reproductive endocrinology diseases including infertility, RPL and polycystic ovary syndrome (PCOS), a hormonal endocrine disorder in women.
Dr. Mak received her MBBS and a PhD in Genetics from the University of London. She completed two Ob/Gyn residencies, the first at Addenbrooke's Hospital in Cambridge, England, and the second at Cedars-Sinai Medical Center in Los Angeles, California. While finishing her fellowship in Reproductive Endocrinology and Infertility at the University of Pennsylvania, she was recruited by Yale University as a Women’s Reproductive Health Research (WRHR) scholar. The national WRHR program, funded by the National Institute of Health, is a physician-scientist training program for obstetricians and gynecologists.
Dr. Mak also conducts research at the Yale Stem Cell Center, where the “Mak Lab” is set up for her ongoing use. Her interests include understanding oocyte and early embryo biology which will help patients faced with infertility issues and recurrent pregnancy loss. Through continuous research she is able to explore promising new developments and pass her knowledge along to her patients.
Dr. Mak is a member of the American College of Obstetricians and Gynecologists, the American Society for Reproductive Medicine (ASRM) and the Society for Reproductive Investigation. Dr. Mak has been honored with an ASRM research award and the Albert S. McKern Research Scholarship. This scholarship is offered by the University of Sydney in Australia to postgraduates conducting research into the cause, prevention and treatment of mental and physical pain and distress during all stages of a woman’s pregnancy.
Departments & Organizations
- Discovery to Cure Internship
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Fellowship
- University of Pennsylvania (2011)
- Residency
- Cedars-Sinai Medical Center, Los Angeles (2008)
- PhD
- University of London (2004)
- Residency
- St. Mary's Hospital (2000)
- Residency
- Addenbrooke's Hospital (1999)
- MBBS
- University of London (1997)
Research
Copy Link
Overview
Medical Research Interests
ORCID
0000-0003-4885-4446
Research at a Glance
Publications Timeline
Research Interests
Placenta
Publications
2025
PRENATAL ANXIETY AND DEPRESSION SCORES IN NULLIPAROUS WOMEN WITH RECURRENT PREGNANCY LOSS
Schenken C, Roshong A, Conley P, Bello N, Mak W. PRENATAL ANXIETY AND DEPRESSION SCORES IN NULLIPAROUS WOMEN WITH RECURRENT PREGNANCY LOSS. Fertility And Sterility 2025, 124: e89-e90. DOI: 10.1016/j.fertnstert.2025.07.312.Peer-Reviewed Original Research
2024
Perinatal outcomes of women with recurrent pregnancy loss undergoing frozen embryo transfer from the Society of Assisted Reproductive Technology database
Go V, Goros M, Choi B, Farland L, Robinson R, Mak W. Perinatal outcomes of women with recurrent pregnancy loss undergoing frozen embryo transfer from the Society of Assisted Reproductive Technology database. Fertility And Sterility 2024, 123: 644-652. PMID: 39427823, PMCID: PMC11993351, DOI: 10.1016/j.fertnstert.2024.10.016.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHistory of recurrent pregnancy lossFrozen embryo transferRecurrent pregnancy lossSociety for Assisted Reproductive Technology Clinic Outcome Reporting System databaseRisk of adverse perinatal outcomesAdverse perinatal outcomesPerinatal outcomesTubal ligationMode of deliveryPregnancy lossPreterm deliveryGestational ageNeonatal deathLow birthweightEmbryo transferLive birthsDiagnosis of recurrent pregnancy lossReporting System databasePerinatal outcomes of womenRisk of neonatal deathPreimplantation genetic testingOutcomes of womenRetrospective cohort studyHistory of infertilityDays of lifeFERTILITY ED: EVALUATING THE EFFECTIVENESS OF SOCIAL MEDIA AS A TOOL TO INCREASE FERTILITY AWARENESS AMONG GRADUATE STUDENTS
Shaffer J, Desposorio J, Talkad A, Mak W, Alvarez M, Shields C. FERTILITY ED: EVALUATING THE EFFECTIVENESS OF SOCIAL MEDIA AS A TOOL TO INCREASE FERTILITY AWARENESS AMONG GRADUATE STUDENTS. Fertility And Sterility 2024, 122: e140. DOI: 10.1016/j.fertnstert.2024.07.516.Peer-Reviewed Original ResearchCitationsIMPACT OF AGE ON THE EFFECTIVENESS OF FERTILITY AWARENESS EDUCATION (FERTILITYED) FOLLOWING EXPOSURE TO TikTokTM-STYLE VIDEOS VERSUS BROCHURE
Desposorio J, Shields C, Alvarez M, Shaffer J, Talkad A, Mak W. IMPACT OF AGE ON THE EFFECTIVENESS OF FERTILITY AWARENESS EDUCATION (FERTILITYED) FOLLOWING EXPOSURE TO TikTokTM-STYLE VIDEOS VERSUS BROCHURE. Fertility And Sterility 2024, 122: e134. DOI: 10.1016/j.fertnstert.2024.07.501.Peer-Reviewed Original ResearchNEONATAL OUTCOMES OF PATIENTS UNDERGOING INTRAVAGINAL CULTURE COMPARED TO TRADITIONAL IN VITRO FERTILIZATION: A SART CORS STUDY
Kostroun K, Choi B, Roshong A, Mak W. NEONATAL OUTCOMES OF PATIENTS UNDERGOING INTRAVAGINAL CULTURE COMPARED TO TRADITIONAL IN VITRO FERTILIZATION: A SART CORS STUDY. Fertility And Sterility 2024, 122: e299. DOI: 10.1016/j.fertnstert.2024.07.919.Peer-Reviewed Original Research
2023
NEONATAL OUTCOMES OF PATIENTS WITH RECURRENT PREGNANCY LOSS UNDERGOING FROZEN EMBRYO TRANSFER: A SART CORS STUDY
Go V, Kostroun K, Goros M, Farland L, Robinson R, Mak W. NEONATAL OUTCOMES OF PATIENTS WITH RECURRENT PREGNANCY LOSS UNDERGOING FROZEN EMBRYO TRANSFER: A SART CORS STUDY. Fertility And Sterility 2023, 120: e39. DOI: 10.1016/j.fertnstert.2023.08.142.Peer-Reviewed Original ResearchA SURVEY STUDY TO ASSESS THE IMPACT OF ROE V. WADE REVERSAL ON REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY FELLOWS
Kostroun K, Go V, Hartup L, Mak W. A SURVEY STUDY TO ASSESS THE IMPACT OF ROE V. WADE REVERSAL ON REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY FELLOWS. Fertility And Sterility 2023, 120: e32. DOI: 10.1016/j.fertnstert.2023.08.730.Peer-Reviewed Original ResearchConcepts
2014
In Vitro Culture Increases the Frequency of Stochastic Epigenetic Errors at Imprinted Genes in Placental Tissues from Mouse Concepti Produced Through Assisted Reproductive Technologies1
de Waal E, Mak W, Calhoun S, Stein P, Ord T, Krapp C, Coutifaris C, Schultz RM, Bartolomei MS. In Vitro Culture Increases the Frequency of Stochastic Epigenetic Errors at Imprinted Genes in Placental Tissues from Mouse Concepti Produced Through Assisted Reproductive Technologies1. Biology Of Reproduction 2014, 90: 22, 1-12. PMID: 24337315, PMCID: PMC4076403, DOI: 10.1095/biolreprod.113.114785.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEpigenetic errorsEpigenetic defectsART-conceived offspringImprinted genesMammalian embryosDNA methylationEpigenetic profilesPreimplantation developmentEpigenetic abnormalitiesAssisted Reproductive TechnologyMammalian speciesMouse conceptiMouse embryosExpression profilesEmbryonic tissuesAbnormal methylationGenesEmbryosPlacental tissueIVF embryosVitro CultureMethylationHigh oxygen tensionLow birth weightMillions of couples
2013
Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females
McGraw S, Oakes CC, Martel J, Cirio MC, de Zeeuw P, Mak W, Plass C, Bartolomei MS, Chaillet JR, Trasler JM. Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females. PLOS Genetics 2013, 9: e1003873. PMID: 24278026, PMCID: PMC3836718, DOI: 10.1371/journal.pgen.1003873.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsImprinted X-chromosome inactivationX-chromosome inactivationChromosome inactivationImprinted X inactivationDNA methylation eventsX-inactivation centerDNA methylation patternsKey regulatory regionsGenomic imprintsMethylation maintenanceGenomic imprintingImprinted lociFemale blastocystsMethylation eventsExtraembryonic tissuesBiallelic expressionMethylation patternsRegulatory regionsPreimplantation developmentAffected lociX chromosomeX inactivationMouse embryosDNA hypomethylationPreimplantation embryos
2011
National study of factors influencing assisted reproductive technology outcomes with male factor infertility
Nangia AK, Luke B, Smith JF, Mak W, Stern JE, Group T. National study of factors influencing assisted reproductive technology outcomes with male factor infertility. Fertility And Sterility 2011, 96: 609-614. PMID: 21733503, DOI: 10.1016/j.fertnstert.2011.06.026.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClinical intrauterine gestationMale factor infertilityFactor infertilityICSI cyclesTubal ligationAssisted Reproductive Technology Clinic Outcome Reporting System databaseLB rateMale factor infertility casesHistoric cohort studyReproductive technology cyclesClinic-based dataReproductive technology outcomesMultivariate logistic regressionReporting System databaseCohort studyIntrauterine gestationICSI outcomesInfertility casesWorse outcomesOdds ratioMAIN OUTCOMESperm injectionInfertilityLogistic regressionSperm collection
Get In Touch
Copy Link