2023
Does Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships?
Etkin R, Juel E, Lebowitz E, Silverman W. Does Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships? Clinical Child And Family Psychology Review 2023, 26: 1052-1076. PMID: 37838627, DOI: 10.1007/s10567-023-00454-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdolescentAnxietyAnxiety DisordersChildCognitive Behavioral TherapyHumansSocial InteractionTreatment OutcomeConceptsCognitive behavioral therapyAdolescent anxiety disordersPeer relationshipsSocial functioningAnxiety disordersYouth anxiety disordersPeer outcomesAnxiety reductionTreatment-specific effectsFunctioningTreatment specificitySystematic narrative reviewRelated difficultiesSample characteristicsMajority of studiesSpecific outcomesChildrenTreatment outcomesStatistical findingsStudy sampleDisordersNarrative reviewFindingsRelationshipAnxietyEffect modification of an effective transdiagnostic cognitive behavioral psychotherapy in youths with common mental health problems: Secondary analyses of the randomized mind-my-mind trial
Rimvall M, Vassard D, Nielsen S, Wolf R, Plessen K, Bilenberg N, Thomsen P, Thastum M, Neumer S, Puggaard L, Pedersen M, Pagsberg A, Silverman W, Correll C, Christensen R, Jeppesen P. Effect modification of an effective transdiagnostic cognitive behavioral psychotherapy in youths with common mental health problems: Secondary analyses of the randomized mind-my-mind trial. European Neuropsychopharmacology 2023, 74: 64-75. PMID: 37279641, DOI: 10.1016/j.euroneuro.2023.05.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCognitionCognitive Behavioral TherapyEmotionsHumansMental DisordersMental HealthTreatment OutcomeConceptsMental health problemsPotential effect modifiersHealth problemsDifferential treatment effectsTreatment benefitEffect modifiersUntreated mental health problemsSubstantial mental health problemsCommon mental health problemsTreatment effectsLocal community settingsCommunity-based programsBaseline factorsTreat analysisClinical variablesEffect modificationCognitive-behavioral psychotherapyDiagnostic criteriaMIND trialSociodemographic factorsTrial dataMental disordersSecondary analysisCommunity settingsCBT treatmentParent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome
Cabrera V, Buitron V, Patriarca G, Rey Y, Lebowitz E, Silverman W, Pettit J. Parent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome. Behavior Therapy 2023, 54: 852-862. PMID: 37597962, PMCID: PMC10440415, DOI: 10.1016/j.beth.2023.03.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersChildCognitive Behavioral TherapyFemaleHumansMaleParentsTreatment OutcomeConceptsYouth anxiety severityParent accommodationCognitive-behavioral treatmentYouth irritabilityAnxiety treatment outcomesAnxiety severityChild anxietyPrimary anxiety disorder diagnosisAnxiety disorder diagnosisAnxious youthYouth anxietyYouth ages 6Adolescent irritabilityAnxiety outcomesBehavioral treatmentAnxiety protocolAnxietyGreater impairmentDisorder diagnosisAge 6Treatment outcomesFuture researchPosttreatmentIrritabilityResearch documentsThe Therapy Process Observational Coding System: Group cohesion scale in youth anxiety treatment: Psychometric properties
Fjermestad K, McLeod B, Silverman W, Bjaastad J, Lerner M, Wergeland G. The Therapy Process Observational Coding System: Group cohesion scale in youth anxiety treatment: Psychometric properties. Journal Of Clinical Psychology 2023, 79: 1726-1739. PMID: 36799300, DOI: 10.1002/jclp.23496.Peer-Reviewed Original Research
2022
Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth
Pettit J, Rey Y, Marin C, Bechor M, Lebowitz E, Vasey M, Jaccard J, Abend R, Pine D, Bar-Haim Y, Silverman W. Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth. Behavior Therapy 2022, 54: 77-90. PMID: 36608979, PMCID: PMC9825787, DOI: 10.1016/j.beth.2022.07.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersAttentional BiasChildChild, PreschoolCognitive Behavioral TherapyHumansMaleTreatment OutcomeConceptsAttention Bias Modification TreatmentAttention control trainingAttention trainingAnxiety severityAttention controlAnxiety levelsAttention biasNeutral facesLow-intensity treatmentGlobal impairmentDot-probe taskYouth anxiety severityClinic-Referred YouthFull criteriaAttention focusingControl trainingTreatment researchYouthIndependent evaluatorsTrainingImpairment ratingsACT trialsPosttreatmentSeverity ratingsRatingsYouth social functioning interacts with treatment arm, diagnosis, and gender to predict anxiety treatment outcome
Etkin RG, Marin CE, Silverman WK, Lebowitz ER. Youth social functioning interacts with treatment arm, diagnosis, and gender to predict anxiety treatment outcome. Behaviour Research And Therapy 2022, 156: 104160. PMID: 35870327, DOI: 10.1016/j.brat.2022.104160.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersCognitive Behavioral TherapyFemaleHumansMaleSocial InteractionTreatment OutcomeConceptsAnxiety treatment outcomesYouth social functioningSocial skillsPositive social interactionsSocial functioningAnxiety diagnosesAnxiety disordersSocial interactionParent-based treatmentChildren's social skillsSocial anxiety disorderYouths' social skillsAnxiety symptom severityYouth genderTreatment outcomesDiagnostic InterviewSymptom severityClinical functioningFunctioningSkillsYouthPredictorsMultiple regression modelDisordersGender
2021
Directional effects of parent and child anxiety 1 year following treatment of child anxiety, and the mediational role of parent psychological control
Silverman WK, Marin CE, Rey Y, Jaccard J, Pettit JW. Directional effects of parent and child anxiety 1 year following treatment of child anxiety, and the mediational role of parent psychological control. Depression And Anxiety 2021, 38: 1289-1297. PMID: 34464490, PMCID: PMC8664994, DOI: 10.1002/da.23210.Peer-Reviewed Original ResearchConceptsParents’ psychological controlPsychological controlChild anxietyCognitive behavioral therapyParent anxietyIndividual cognitive behavioral therapyChild's ageAnxiety 1 yearTreatment targetsMediational roleEvidence of childrenBehavioral therapyRecent efficacy trialsParent involvementAnxietyPosttreatmentDirectional effectsParentsClinical implicationsCBT armEvidence of parentChildrenTreatment effectsModeratorEfficacy trialsModerators of response to child‐based and parent‐based child anxiety treatment: a machine learning‐based analysis
Lebowitz ER, Zilcha‐Mano S, Orbach M, Shimshoni Y, Silverman WK. Moderators of response to child‐based and parent‐based child anxiety treatment: a machine learning‐based analysis. Journal Of Child Psychology And Psychiatry 2021, 62: 1175-1182. PMID: 33624848, DOI: 10.1111/jcpp.13386.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyAnxiety DisordersChildCognitive Behavioral TherapyHumansMachine LearningParentingTreatment OutcomeConceptsModerators of responseParent negativityChild anxiety treatmentOxytocin levelsBaseline anxietyCognitive behavioral therapyPrimary anxiety disorderChild-reported outcomesParent-reported outcomesChildhood anxietyAnxiety treatmentAnxiety symptomsPotential moderatorsAnxiety disordersTreatment conditionsModeratorMachine learning-based analysisAnxietyNegativitySignificant interactionChildrenNonoptimal treatmentTreatment efficacyParentingSocioemotional
2020
Parent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment
Zilcha-Mano S, Shimshoni Y, Silverman WK, Lebowitz ER. Parent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment. Journal Of Clinical Child & Adolescent Psychology 2020, 50: 427-439. PMID: 32401557, PMCID: PMC8496486, DOI: 10.1080/15374416.2020.1756300.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyChildCognitive Behavioral TherapyFemaleHumansMaleParent-Child RelationsParentingTreatment OutcomeConceptsParent-child agreementFamily accommodationMultilevel response-surface analysisAnxious Childhood EmotionsChild anxiety treatmentChild anxiety severityCognitive behavioral therapyAnxiety symptom severityDistinct underlying mechanismsChildhood EmotionsChildhood anxietySupportive parentingAnxiety treatmentParent reportBehavioral therapyRole of accommodationAnxiety severityAnxiety disordersPoor treatment outcomesTreatment outcomesSymptom severitySubsequent treatment outcomesTreatment endSignificant predictorsChildren
2019
Efficacy and mechanisms underlying a gamified attention bias modification training in anxious youth: protocol for a randomized controlled trial
Linke JO, Jones E, Pagliaccio D, Swetlitz C, Lewis KM, Silverman WK, Bar-Haim Y, Pine DS, Brotman MA. Efficacy and mechanisms underlying a gamified attention bias modification training in anxious youth: protocol for a randomized controlled trial. BMC Psychiatry 2019, 19: 246. PMID: 31391027, PMCID: PMC6686536, DOI: 10.1186/s12888-019-2224-2.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyContext of CBTBias modification trainingDot-probe taskAttentional biasAnxious youthAmygdala connectivityAnxiety disordersAttention bias modification trainingPrimary anxiety disorder diagnosisHealthy comparison youthAnxiety disorder diagnosisVisual searchThreat responsesNeurobiological correlatesComparison youthBehavioral therapyTraining elementsDisorder diagnosisEngaging gameNeuronal levelYouthPrevious findingsMixed resultsTaskA Randomized Controlled Trial of Attention Bias Modification Treatment in Youth With Treatment-Resistant Anxiety Disorders
Pettit JW, Bechor M, Rey Y, Vasey MW, Abend R, Pine DS, Bar-Haim Y, Jaccard J, Silverman WK. A Randomized Controlled Trial of Attention Bias Modification Treatment in Youth With Treatment-Resistant Anxiety Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 157-165. PMID: 30877049, PMCID: PMC6744353, DOI: 10.1016/j.jaac.2019.02.018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersAttentional BiasChildCognitive Behavioral TherapyFemaleHumansMaleTreatment OutcomeConceptsAttention Bias Modification TreatmentAttention control trainingTreatment-resistant anxiety disordersAttention controlAnxiety severityAttention biasNeutral facesAnxiety disordersAttention bias modification trainingBias modification trainingYouth anxiety severityCognitive behavioral therapyAttention trainingDiagnostic recoveryAnxiety diagnosesControl trainingTraining trialsContingency scheduleYouthModification treatmentIndependent evaluatorsAnxietyTrainingAugmentation strategiesFaceParent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions
Lebowitz ER, Marin C, Martino A, Shimshoni Y, Silverman WK. Parent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 362-372. PMID: 30851397, PMCID: PMC6732048, DOI: 10.1016/j.jaac.2019.02.014.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyAnxiety DisordersChildCognitionCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedParentingTreatment OutcomeConceptsParent-based treatmentAnxious Childhood EmotionsChildhood anxiety disordersFamily accommodationChildhood anxietyAnxiety disordersChildhood EmotionsSupportive parentingParenting stressAnxiety outcomesCognitive behavioral therapyPrimary anxiety disorderParent interventionBehavioral therapyChildren's ratingsAnxiety severityTreatment credibilityClinician-rated scalesParent treatmentParent involvementAnxietyDiagnostic InterviewEmotionsParentingIndependent evaluatorsTrajectories and Predictors of Response in Youth Anxiety CBT: Integrative Data Analysis
Skriner LC, Chu BC, Kaplan M, Bodden DHM, Bögels SM, Kendall PC, Nauta MH, Silverman WK, Wood JJ, Barker DH, de la Torre J, Saavedra L, Xie MG. Trajectories and Predictors of Response in Youth Anxiety CBT: Integrative Data Analysis. Journal Of Consulting And Clinical Psychology 2019, 87: 198-211. PMID: 30570308, DOI: 10.1037/ccp0000367.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersChildCognitive Behavioral TherapyFemaleHumansMaleTreatment OutcomeConceptsCognitive behavioral therapyGrowth mixture modelingIntegrative data analysisParent-reported anxiety symptomsFamily cognitive-behavioral therapySymptom changeTrajectory classesYouth-reported symptomsParent-reported symptomsMixture modelingPredictors of trajectoriesItem response theory modelsAnxious youthImprovement classesAnxiety symptomsRapid respondersResponse classesYouthTheory modelPredictorsDistinct patternsOlder agePredictors of responseMembershipSymptomsA Cost Analysis of a Stepped Care Treatment Approach for Anxiety Disorders in Youth
Yeguez CE, Page TF, Rey Y, Silverman WK, Pettit JW. A Cost Analysis of a Stepped Care Treatment Approach for Anxiety Disorders in Youth. Journal Of Clinical Child & Adolescent Psychology 2019, 49: 549-555. PMID: 30644757, PMCID: PMC6629529, DOI: 10.1080/15374416.2018.1539913.Peer-Reviewed Original Research
2017
Can less be more? Open trial of a stepped care approach for child and adolescent anxiety disorders
Pettit JW, Rey Y, Bechor M, Melendez R, Vaclavik D, Buitron V, Bar-Haim Y, Pine DS, Silverman WK. Can less be more? Open trial of a stepped care approach for child and adolescent anxiety disorders. Journal Of Anxiety Disorders 2017, 51: 7-13. PMID: 28843575, PMCID: PMC5610647, DOI: 10.1016/j.janxdis.2017.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAnxiety DisordersAttentional BiasChildCognitive Behavioral TherapyFemaleHumansMaleParentsTherapy, Computer-AssistedTreatment OutcomeConceptsYouth anxiety severityAnxiety severityAnxiety disordersCognitive-behavioral therapy protocolAdolescent anxiety disordersCo-occurring ADHDBehavioral therapy protocolAnxiety disorder treatmentHigher anxiety severityLow-intensity treatmentClinical Global Impressions-Improvement scaleHigh-intensity treatmentDisorder treatmentYouthCare treatment approachMindfulness-Based Stress Reduction for Adolescents with Functional Somatic Syndromes: A Pilot Cohort Study
Ali A, Weiss TR, Dutton A, McKee D, Jones KD, Kashikar-Zuck S, Silverman WK, Shapiro ED. Mindfulness-Based Stress Reduction for Adolescents with Functional Somatic Syndromes: A Pilot Cohort Study. The Journal Of Pediatrics 2017, 183: 184-190. PMID: 28088398, PMCID: PMC5367961, DOI: 10.1016/j.jpeds.2016.12.053.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChronic DiseaseCohort StudiesDisability EvaluationFatigue Syndrome, ChronicFemaleFibromyalgiaHeadacheHumansIrritable Bowel SyndromeMaleMindfulnessMusculoskeletal PainPilot ProjectsPrognosisRisk AdjustmentRisk AssessmentStatistics, NonparametricStress, PsychologicalTreatment OutcomeConceptsFunctional Disability InventoryFunctional somatic syndromesSomatic syndromesSymptom Impact QuestionnaireWidespread chronic painPilot cohort studyCohort of subjectsFunctional somatic symptomsPerceived Stress Scale scoresMindfulness-based stress reduction programStress Scale scoresParent-completed measureAdverse eventsCohort studyStress reduction programChronic painFunctional disabilityImpact QuestionnaireSymptom impactDisability InventoryPediatric QualityPerceived Stress ScaleClinical utilityDaily livingAcceptable intervention
2016
Genome-wide association study of response to cognitive–behavioural therapy in children with anxiety disorders
Coleman JR, Lester KJ, Keers R, Roberts S, Curtis C, Arendt K, Bögels S, Cooper P, Creswell C, Dalgleish T, Hartman CA, Heiervang ER, Hötzel K, Hudson JL, In-Albon T, Lavallee K, Lyneham HJ, Marin CE, Meiser-Stedman R, Morris T, Nauta MH, Rapee RM, Schneider S, Schneider SC, Silverman WK, Thastum M, Thirlwall K, Waite P, Wergeland GJ, Breen G, Eley TC. Genome-wide association study of response to cognitive–behavioural therapy in children with anxiety disorders. The British Journal Of Psychiatry 2016, 209: 236-243. PMID: 26989097, PMCID: PMC5007453, DOI: 10.1192/bjp.bp.115.168229.Peer-Reviewed Original ResearchGenetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders
Lester KJ, Coleman JR, Roberts S, Keers R, Breen G, Bögels S, Creswell C, Hudson JL, McKinnon A, Nauta M, Rapee RM, Schneider S, Silverman WK, Thastum M, Waite P, Wergeland GJ, Eley TC. Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 144-155. PMID: 27346075, PMCID: PMC5324578, DOI: 10.1002/ajmg.b.32467.Peer-Reviewed Original ResearchConceptsAnxiety disorder diagnosisIndividual differencesPrimary anxiety disorder diagnosisSuccessful psychological treatmentDisorder diagnosisCognitive behavior therapyAnxiety disorder severityExtinction learningFear extinctionPsychological treatmentBehavior therapyDisorder severityPoor treatment responseSymptom severityEffect sizeFull sampleEndocannabinoid systemFearTreatment responseCBTAnxietyPotential clinical utilityLimited evidenceLearningChildrenNon-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders
Lester KJ, Roberts S, Keers R, Coleman JR, Breen G, Wong CC, Xu X, Arendt K, Blatter-Meunier J, Bögels S, Cooper P, Creswell C, Heiervang ER, Herren C, Hogendoorn SM, Hudson JL, Krause K, Lyneham HJ, McKinnon A, Morris T, Nauta MH, Rapee RM, Rey Y, Schneider S, Schneider SC, Silverman WK, Smith P, Thastum M, Thirlwall K, Waite P, Wergeland GJ, Eley TC. Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders. The British Journal Of Psychiatry 2016, 208: 182-188. PMID: 26294368, PMCID: PMC4837384, DOI: 10.1192/bjp.bp.114.154997.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCBT outcomeChild anxietyAnxiety disordersChild anxiety disordersMore positive outcomesShort-allele homozygotesPositive treatment outcomesPsychological therapiesDisorder outcomesPositive outcomesTreatment studiesHomogenous sampleMixed resultsAnxietyMixed effects modelsNon-significant effectTreatment outcomesCohort 2DisordersSignificant associationFuture studiesOutcomesAssociationTherapy
2015
Predictors of treatment outcome in an effectiveness trial of cognitive behavioral therapy for children with anxiety disorders
Wergeland GJ, Fjermestad KW, Marin CE, Bjelland I, Haugland BS, Silverman WK, Öst LG, Bjaastad JF, Oeding K, Havik OE, Heiervang ER. Predictors of treatment outcome in an effectiveness trial of cognitive behavioral therapy for children with anxiety disorders. Behaviour Research And Therapy 2015, 76: 1-12. PMID: 26583954, DOI: 10.1016/j.brat.2015.11.001.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyChild-rated anxiety symptomsParent internalizing symptomsAnxiety disordersAnxiety symptomsCBT programInternalizing symptomsSocial phobiaBehavioral therapyLower family social classPrimary anxiety disorderSeparation anxiety disorderPositive treatment outcomesFamily social classChildren of parentsAnxious childrenEffectiveness trialChildren's motivationParent factorsSeparation anxietyTreatment outcomesSymptom levelsRecent effectiveness studiesPoor outcomePhobia