2010
Genome-wide analysis of germ cell proliferation in C . elegans identifies VRK-1 as a key regulator of CEP-1/p53
Waters K, Yang AZ, Reinke V. Genome-wide analysis of germ cell proliferation in C . elegans identifies VRK-1 as a key regulator of CEP-1/p53. Developmental Biology 2010, 344: 1011-1025. PMID: 20599896, PMCID: PMC3375680, DOI: 10.1016/j.ydbio.2010.06.022.Peer-Reviewed Original ResearchConceptsGerm cell proliferationVRK-1Germ cellsCEP-1CEP-1/p53Cell proliferationImportant regulatory relationshipsGenome-wide analysisGene expression profilingGermline proliferationCell cycle arrestUseful model systemC. elegansProliferation defectFunctional characterizationNegative regulationExpression profilingRegulatory relationshipsKey regulatorP53 activityCycle arrestUnsuspected mechanismElegansModel systemProliferation
2002
A Targeted RNAi Screen for Genes Involved in Chromosome Morphogenesis and Nuclear Organization in the Caenorhabditis elegans Germline
Colaiácovo M, Stanfield G, Reddy K, Reinke V, Kim S, Villeneuve A. A Targeted RNAi Screen for Genes Involved in Chromosome Morphogenesis and Nuclear Organization in the Caenorhabditis elegans Germline. Genetics 2002, 162: 113-128. PMID: 12242227, PMCID: PMC1462232, DOI: 10.1093/genetics/162.1.113.Peer-Reviewed Original ResearchConceptsChromosome morphogenesisNuclear organizationRNA interferenceCaenorhabditis elegans germlineFunctional genomic strategiesMeiotic prophase eventsTargeted RNAi screenGene expression surveyDNA microarray technologyGermline phenotypeGermline proliferationMeiosis genesChromosome organizationMitotic growthRNAi screenGenomic strategiesMeiotic progressionMeiotic prophaseExpression profilesMicroarray technologyGermlineGenesMorphogenesisCaenorhabditisProphase