Identification of renin signaling as a blood pressure modifying mechanism in soluble guanylate cyclase α1-deficient mice
Buys E, Raher M, Kirby A, Mohd S, Baron D, Hayton S, Tainsh L, Sips P, Rauwerdink K, Tainsh R, Shakartzi H, Stevens C, Decaluwé K, da Gloria Rodrigues-Machado M, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly M, Bloch K. Identification of renin signaling as a blood pressure modifying mechanism in soluble guanylate cyclase α1-deficient mice. Nitric Oxide 2012, 27: s25-s26. DOI: 10.1016/j.niox.2012.04.093.Peer-Reviewed Original ResearchRenin-angiotensin-aldosterone systemQuantitative trait lociRenin-angiotensin-aldosterone system signalingPlasma angiotensin II levelsEtiology of human hypertensionPlasma aldosterone levelsGlomerular filtration rateNitric oxideNO-cGMP signalingAngiotensin II levelsEndothelium-dependent vasorelaxationImpaired NO-cGMP signalingBlood urea nitrogenSubunit of soluble guanylate cyclaseAssociated with increased activitySoluble guanylate cyclaseImproving endothelium-dependent vasorelaxationRegulating blood pressureAldosterone levelsB6 miceMale F2 offspringNO-cGMPRenal functionUrinary volumeEssential hypertension