2015
Regulation of glomerulotubular balance. III. Implication of cytosolic calcium in flow-dependent proximal tubule transport
Du Z, Weinbaum S, Weinstein A, Wang T. Regulation of glomerulotubular balance. III. Implication of cytosolic calcium in flow-dependent proximal tubule transport. American Journal Of Physiology. Renal Physiology 2015, 308: f839-f847. PMID: 25651568, PMCID: PMC4398834, DOI: 10.1152/ajprenal.00601.2014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicarbonatesBiological TransportCalciumCalcium-Transporting ATPasesChelating AgentsCytosolEnzyme InhibitorsIn Vitro TechniquesInositol 1,4,5-Trisphosphate ReceptorsKidney Tubules, ProximalKineticsMice, Inbred C57BLPerfusionRenal ReabsorptionSodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsNa/H exchanger 3Luminal Ca(2Flow-induced increaseCytosolic calciumProximal tubulesCa(2+) chelator BAPTA-AMAntagonist 2-aminoethoxydiphenyl borateCa-ATPase inhibitor thapsigarginProximal tubule transportNa(+) reabsorptionMicroperfused in vitroMouse proximal tubuleChelator BAPTA-AMH-ATPase activityNo effectControl tubulesInhibitor thapsigarginBAPTA-AMIntracellular Ca(2Decreased transportTubule transportBaseline transportStimulates Na(+Modulate Na(+Glomerulotubular balance
2011
DOPAMINE MODULATES FLOW‐DEPENDENT TRANSPORT BY NHE3, BUT NOT H+‐ATPASE, IN MOUSE PROXIMAL TUBULES
Du Z, Gotoh N, Weinbaum S, Weinstein A, Wang T. DOPAMINE MODULATES FLOW‐DEPENDENT TRANSPORT BY NHE3, BUT NOT H+‐ATPASE, IN MOUSE PROXIMAL TUBULES. The FASEB Journal 2011, 25: 1041.18-1041.18. DOI: 10.1096/fasebj.25.1_supplement.1041.18.Peer-Reviewed Original ResearchEffects of DAProtein kinase A inhibitor H89Proximal tubules in vitroPKA-mediated mechanismProximal tubule transportReabsorption of fluidTubules in vitroHCO3- absorptionLuminal perfusion rateTubule transportJHCO3Cl- transportProximal tubulesNHE3Perfusion rateDopamineSCH23390JNaPresence of DAInhibitory effectSignaling mechanismsH+-ATPaseDA1No effectFlow-dependent transport
1990
Cholinergic effect on rat proximal convoluted tubule
Wang T, Chan Y. Cholinergic effect on rat proximal convoluted tubule. Pflügers Archiv - European Journal Of Physiology 1990, 415: 533-539. PMID: 2109302, DOI: 10.1007/bf02583503.Peer-Reviewed Original ResearchConceptsPCT transportProximal convoluted tubulesA-23187Cholinergic receptorsHigher doses of carbacholInhibitory effect of carbacholRate of bicarbonate absorptionConvoluted tubulesCholinergic effectsRegulation of renal functionRat proximal convoluted tubuleEffects of cholinergic agentsEffect of carbacholAddition of carbacholDose of carbacholFunctional cholinergic receptorsCarbachol-induced effectsProximal tubular absorptionIonophore A-23187Bicarbonate-Ringer solutionInhibitory effectNo effectRenal functionBasolateral sideCalcium influx