1998
A tyrosine-based signal regulates H-K-ATPase-mediated potassium reabsorption in the kidney
Wang T, Courtois-Coutry N, Giebisch G, Caplan M. A tyrosine-based signal regulates H-K-ATPase-mediated potassium reabsorption in the kidney. American Journal Of Physiology 1998, 275: f818-f826. PMID: 9815140, DOI: 10.1152/ajprenal.1998.275.5.f818.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateTransgenic miceGastric acid outputPlasma K concentrationK pumpK-ATPaseRenal collecting tubulesK clearanceBlood pressurePotassium reabsorptionAcid outputUrine volumeK excretionFiltration rateGastric acidK reabsorptionPump functionCollecting tubuleMicePlasma NaTyrosine-based sequenceTyrosine-based signalsKidneyExcretionCytoplasmic tailTubule Function in Transgenic Mice
Wang T, Giebisch G. Tubule Function in Transgenic Mice. Experimental Nephrology 1998, 6: 447-453. PMID: 9730661, DOI: 10.1159/000020554.Peer-Reviewed Original ResearchConceptsNa-HK-ATPaseK-ATPase expressionRenal tubule transportRenal electrolyte transportStrains of miceRenal transport functionsTransport functionColonic isoformH,K-ATPaseIsoforms NHE2Isoforms NHE1Tubule transportTubule functionTubule segmentsMouse modelTransgenic miceTransgenic knockoutTransport lesionKnockout modelsMiceKidney tubulesElectrolyte transportNull mutationTubules
1995
Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes
Ohno A, Beck F, Pfaller W, Giebisch G, Wang T. Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes. Kidney International 1995, 48: 712-721. PMID: 7474656, DOI: 10.1038/ki.1995.342.Peer-Reviewed Original ResearchConceptsK-ATPase activityProximal tubulesUNX ratsNa/H exchangeBicarbonate absorptionBicarbonate transportResponse to unilateral nephrectomyNa,K-ATPase activityBasolateral ion transportStimulation of bicarbonateBasolateral NaChronic hyperfiltrationMaximal transport rateRemnant kidneyUnilateral nephrectomyCortical tubulesFiltration rateRenal clearanceUNXBicarbonate levelsK-ATPaseRubidium uptakeH secretionFluid absorptionCell ion concentrations