2012
Identification of renin signaling as a blood pressure modifying mechanism in soluble guanylate cyclase α1-deficient mice
Buys E, Raher M, Kirby A, Mohd S, Baron D, Hayton S, Tainsh L, Sips P, Rauwerdink K, Tainsh R, Shakartzi H, Stevens C, Decaluwé K, da Gloria Rodrigues-Machado M, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly M, Bloch K. Identification of renin signaling as a blood pressure modifying mechanism in soluble guanylate cyclase α1-deficient mice. Nitric Oxide 2012, 27: s25-s26. DOI: 10.1016/j.niox.2012.04.093.Peer-Reviewed Original ResearchRenin-angiotensin-aldosterone systemQuantitative trait lociRenin-angiotensin-aldosterone system signalingPlasma angiotensin II levelsEtiology of human hypertensionPlasma aldosterone levelsGlomerular filtration rateNitric oxideNO-cGMP signalingAngiotensin II levelsEndothelium-dependent vasorelaxationImpaired NO-cGMP signalingBlood urea nitrogenSubunit of soluble guanylate cyclaseAssociated with increased activitySoluble guanylate cyclaseImproving endothelium-dependent vasorelaxationRegulating blood pressureAldosterone levelsB6 miceMale F2 offspringNO-cGMPRenal functionUrinary volumeEssential hypertension
2003
Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium
Coric T, Hernandez N, de la Rosa D, Shao D, Wang T, Canessa CM. Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium. AJP Gastrointestinal And Liver Physiology 2003, 286: g663-g670. PMID: 14630642, DOI: 10.1152/ajpgi.00364.2003.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAnimalsAntibodies, BlockingAntibody SpecificityBlotting, NorthernCHO CellsColonCricetinaeDNA, ComplementaryEnzyme InductionEpithelial Sodium ChannelsEpitheliumFluorescent Antibody TechniqueImmediate-Early ProteinsIntestinal MucosaNuclear ProteinsPlasmidsProtein Serine-Threonine KinasesRatsRNA, MessengerSignal TransductionSodium ChannelsConceptsDistal colonGlucocorticoid-induced kinase 1Intestinal epitheliumConcentrations of aldosteroneSubunits of ENaCSodium channel activityExpression of ENaCRat intestinal epitheliumKinase 1Aldosterone levelsAldosterone-dependent mannerSingle doseSodium depletionChronic increaseDistal tubulesControl animalsAldosteroneAldosterone inductionRat intestineBasal conditionsColonSodium transportersEpitheliumSites of expressionSGK1