2022
MO345: Clinical Characteristics and Trajectory in a National Cohort of Veterans Treated With Conservative Management Versus Dialysis
Narasaki Y, Rhee C, You A, Mukamel D, Novoa A, Otobe Y, Daza A, Kovesdy C, Crowley S, Nguyen D, Kalantar-Zadeh K. MO345: Clinical Characteristics and Trajectory in a National Cohort of Veterans Treated With Conservative Management Versus Dialysis. Nephrology Dialysis Transplantation 2022, 37: gfac068.055. DOI: 10.1093/ndt/gfac068.055.Peer-Reviewed Original ResearchChronic kidney diseaseAdvanced chronic kidney diseaseEnd-stage renal diseaseConservative managementUS veteransClinical characteristicsIndex eGFRNational cohortNon-dialysis dependent chronic kidney diseaseDependent chronic kidney diseaseUnited States Renal Data SystemAdvanced CKD patientsDominant treatment paradigmNon-dialytic managementReceipt of dialysisForm of dialysisRenal replacement therapySimilar sex distributionVeterans Health AdministrationHealthcare systemVA healthcare systemYounger age distributionCKD cohortCKD outcomesCKD patients
2017
Renal Replacement Therapy and Incremental Hemodialysis for Veterans with Advanced Chronic Kidney Disease
Kalantar‐Zadeh K, Crowley ST, Beddhu S, Chen JLT, Daugirdas JT, Goldfarb DS, Jin A, Kovesdy CP, Leehey DJ, Moradi H, Navaneethan SD, Norris KC, Obi Y, O'Hare A, Shafi T, Streja E, Unruh ML, Vachharajani TJ, Weisbord S, Rhee CM. Renal Replacement Therapy and Incremental Hemodialysis for Veterans with Advanced Chronic Kidney Disease. Seminars In Dialysis 2017, 30: 251-261. PMID: 28421638, PMCID: PMC5418081, DOI: 10.1111/sdi.12601.Peer-Reviewed Original ResearchConceptsResidual kidney functionIncremental hemodialysisDialysis centersDialysis unitsAdvanced chronic kidney diseaseFirst dialysis yearNon-VA centersVA systemChronic kidney diseaseRenal replacement therapyThrice-weekly hemodialysisReceipt of carePatient-centered approachDialysis reimbursementDialysis yearHemodialysis regimenMaintenance dialysisKidney functionPatients' qualityKidney diseaseReplacement therapyVA centersAccess longevityFavorable outcomeIncremental dialysis
2009
Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study
Palevsky PM, O'Connor TZ, Chertow GM, Crowley ST, Zhang JH, Kellum JA, the US Department of Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network. Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study. Critical Care 2009, 13: 310. PMID: 19678919, PMCID: PMC2750132, DOI: 10.1186/cc7901.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRenal replacement therapyAcute Renal Failure Trial Network studyKidney injuryReplacement therapyStudy therapyRenal supportHealth Acute Renal Failure Trial Network studyVeterans Affairs/National InstitutesCause mortalityIll patientsKidney functionContinuous modalitiesStudy investigatorsOptimal doseClinical practiceTherapyVolume managementInjuryNational InstituteNetwork studiesHypotensionPatientsStudy resultsMortality
2008
Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury
Palevsky P, Zhang J, O'Connor T, Chertow G, Crowley S, Choudhury D, Finkel K, Kellum J, Paganini E, Schein R, Smith M, Swanson K, Thompson B, Vijayan A, Watnick S, Star R, Peduzzi P. Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury. New England Journal Of Medicine 2008, 359: 7-20. PMID: 18492867, PMCID: PMC2574780, DOI: 10.1056/nejmoa0802639.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRenal replacement therapyNonrenal organ failureContinuous venovenous hemodiafiltrationIntensive treatment strategiesKidney injuryIll patientsIntensive therapyIntermittent hemodialysisKidney functionOrgan failureRenal supportTreatment strategiesContinuous renal replacement therapyDay 60Intensive renal replacement therapyIntensive renal supportLow-efficiency dialysisCritically Ill PatientsPrimary end pointHemodialysis three timesRate of deathNonrenal organsBaseline characteristicsStable patientsLessons for Successful Study Enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study
Crowley ST, Chertow GM, Vitale J, O'Connor T, Zhang J, Schein RM, Choudhury D, Finkel K, Vijayan A, Paganini E, Palevsky PM, Group F. Lessons for Successful Study Enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study. Clinical Journal Of The American Society Of Nephrology 2008, 3: 955-961. PMID: 18385390, PMCID: PMC2440269, DOI: 10.2215/cjn.05621207.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiasClinical Trials as TopicCritical IllnessHemodiafiltrationHumansInformed ConsentIntensive Care UnitsMulticenter Studies as TopicNational Institutes of Health (U.S.)Patient SelectionRandomized Controlled Trials as TopicRenal DialysisResearch DesignTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsHealth Acute Renal Failure Trial Network studyAcute Renal Failure Trial Network studyVeterans Affairs/National InstitutesAcute kidney injuryEnrollment windowKidney injuryPhysician refusalPotential patientsChronic kidney diseaseRenal replacement therapyNational InstituteEnrollment efficiencyLoss of patientsEligible patientsUnderlying comorbiditiesIll patientsStudy enrollmentKidney diseaseReplacement therapyFuture trialsIntervention trialsClinical equipoiseChronic illnessClinical trialsInclusion criteria