2021
Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Sinha R, Fogelman N, Wemm S, Angarita G, Seo D, Hermes G. Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder. Addiction Biology 2021, 27: e13116. PMID: 34856641, PMCID: PMC9872962, DOI: 10.1111/adb.13116.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional magnetic resonance imagingAlcohol use disorderAlcohol cuesHeavy drinking daysStudy 2Alcohol withdrawal symptomsNeutral visual imagesDrinking daysStudy 1 resultsUse disordersCortico-striatal dysfunctionAlcohol treatment outcomesAlcohol intakeFMRI sessionsResilient copingStriatal responsesPrefrontal cortexStudy 1Chronic alcohol useCorticostriatal dysfunctionStriatal functioningAUD patientsVisual imagesPlacebo treatment
2020
Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms
Sinha R, Wemm S, Fogelman N, Milivojevic V, Morgan PM, Angarita GA, Hermes G, Fox HC. Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms. American Journal Of Psychiatry 2020, 178: 447-458. PMID: 33207935, PMCID: PMC8119326, DOI: 10.1176/appi.ajp.2020.20050609.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcohol AbstinenceAlcoholismAnxietyCentral Nervous System DepressantsCounselingCravingDepressionDouble-Blind MethodEthanolFemaleHumansMaleMiddle AgedPrazosinProof of Concept StudySelf-Help GroupsSleep Wake DisordersSubstance Withdrawal SyndromeTreatment OutcomeConceptsAlcohol withdrawal symptomsHeavy drinking daysAlcohol use disorderDrinks/dayWithdrawal symptomsDrinking daysSecondary outcomesPrazosin efficacyAlcohol cravingSelf-reported drinking daysTreatment of AUDEfficacy of prazosinWithdrawal symptom scoresPoor treatment outcomesGlobal disease burdenCurrent alcohol dependencePrimary outcomeTreat analysisAlcohol use outcomesAlcohol intakeSymptom scoresWeek 12Prognostic indicatorDisease burdenSleep disturbances