2013
Stress as a Common Risk Factor for Obesity and Addiction
Sinha R, Jastreboff AM. Stress as a Common Risk Factor for Obesity and Addiction. Biological Psychiatry 2013, 73: 827-835. PMID: 23541000, PMCID: PMC3658316, DOI: 10.1016/j.biopsych.2013.01.032.BooksConceptsNeurobiology of stressHP foodsIncentive salienceFood motivationIntegrative heuristic modelFood-related motivationDevelopment of addictionBiology of stressNeural mechanismsNeurobiological mechanismsAddiction relapsePalatable foodAddictive drugsAllostatic loadMotivationRisk factorsSalienceHigh levelsNeurobiologyHeuristic modelEnergy homeostasisWeight gainAddictionFuture directionsDopaminergic activityDivergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity
Balodis IM, Molina ND, Kober H, Worhunsky PD, White MA, Sinha R, Grilo CM, Potenza MN. Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity. Obesity 2013, 21: 367-377. PMID: 23404820, PMCID: PMC3610836, DOI: 10.1002/oby.20068.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusCognitive controlBED groupNeural correlatesStroop color-word interference taskColor-word interference taskRight inferior frontal gyrusVentromedial prefrontal cortexDivergent neural substratesFunctional magnetic resonanceInterference taskStroop performanceVmPFC activationDietary restraint scoresInhibitory processingDiminished abilityNeural substratesComparison participantsFrontal gyrusInhibitory controlBiobehavioral processesPrefrontal cortexDietary restraintBehavioral controlRelative hypoactivity
2011
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Journal Of Clinical Investigation 2011, 121: 4161-4169. PMID: 21926468, PMCID: PMC3195474, DOI: 10.1172/jci57873.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsGlucose levelsHyperinsulinemic euglycemic-hypoglycemic clampsBrain regionsFunctional MRIMedial prefrontal cortexMedial prefrontal cortex activationRisk of overeatingLevels of glucosePostprandial reductionPrefrontal cortex activationObese subjectsNonobese individualsMild hypoglycemiaWorldwide epidemicCortex activationPrefrontal cortexFood cuesFood motivationFood stimuliNeural controlObesityInhibitory controlBehavioral measuresVisual cues