2024
Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences
Radoman M, Fogelman N, Lacadie C, Seo D, Sinha R. Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences. American Journal Of Psychiatry 2024, 181: 412-422. PMID: 38706332, PMCID: PMC11117176, DOI: 10.1176/appi.ajp.20230849.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPercentage of heavy drinking daysNeural correlates of stressCue-induced cravingHeavy drinking daysAlcohol cravingSex differencesCorrelates of stressDrinking daysAlcohol cue-induced cravingCue-induced alcohol cravingBed nucleus of the stria terminalisSubgenual anterior cingulate cortexAssessment of alcohol cravingHeavy drinkingAlcohol cue reactivityAssociated with poor treatment outcomesCue-induced responsesNeutral cue exposureAssociated with hypoactivationTreatment-seeking adultsHeavy drinking outcomesEvidence of sex differencesVoxel-based regression analysisAnterior cingulate cortex
2023
Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers
Wemm S, Golden M, Martins J, Fogelman N, Sinha R. Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol And Alcoholism 2023, 58: 653-661. PMID: 37756494, PMCID: PMC10642609, DOI: 10.1093/alcalc/agad061.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeart rate variabilitySocial drinkersAUD groupChronic heavy alcohol useRate variabilityLife-threatening cardiovascular diseaseHRV measuresPatient-related symptomsPatient-reported symptomsHF/LF ratioSevere alcohol use disorderNervous system processesHeavy alcohol useParasympathetic dysfunctionCardiovascular diseaseHeart rate monitoringObservational studySleep difficultiesHeart rateParasympathetic activationUse disordersRSA amplitudeCardiovascular systemDays of monitoringBrain volumes in alcohol use disorder: Do females and males differ? A whole‐brain magnetic resonance imaging mega‐analysis
Maggioni E, Rossetti M, Allen N, Batalla A, Bellani M, Chye Y, Cousijn J, Goudriaan A, Hester R, Hutchison K, Li C, Martin‐Santos R, Momenan R, Sinha R, Schmaal L, Solowij N, Suo C, van Holst R, Veltman D, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Brambilla P, Lorenzetti V. Brain volumes in alcohol use disorder: Do females and males differ? A whole‐brain magnetic resonance imaging mega‐analysis. Human Brain Mapping 2023, 44: 4652-4666. PMID: 37436103, PMCID: PMC10400785, DOI: 10.1002/hbm.26404.Peer-Reviewed Original ResearchMifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study
Haass‐Koffler C, Magill M, Cannella N, Brown J, Aoun E, Cioe P, Sinha R, Swift R, Ciccocioppo R, Leggio L. Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study. Addiction Biology 2023, 28: e13288. PMID: 37369125, PMCID: PMC10313137, DOI: 10.1111/adb.13288.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAlcoholismCravingDouble-Blind MethodEthanolHumansHydrocortisoneMifepristoneConceptsAlcohol use disorderHuman laboratory studiesAdverse eventsAlcohol pharmacokineticsAlcohol cravingSubjective effectsSafety of mifepristonePlacebo-controlled trialStress-induced alcoholLack of effectCue-reactivity procedureBlood pressurePhase 1/2Alcohol drinkingGeneralized Estimating EquationsYohimbine administrationHemodynamic parametersPharmacological interventionsSaliva outputDay administrationUse disordersMifepristoneNon-treatment seekersAlcohol consumptionPlacebo conditionHypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology
Syed S, Sinha R, Milivojevic V, MacDougall A, LaValle H, Angarita G, Fox H. Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology. Human Psychopharmacology Clinical And Experimental 2023, 38: e2867. PMID: 37165544, DOI: 10.1002/hup.2867.Peer-Reviewed Original ResearchConceptsAlcohol use disorderRelapse riskDepressive symptomatologyDepressive symptomsAutonomic responsesIndividual relapse riskChronic alcohol useDepressive pathophysiologyAdrenocorticotropic hormoneInhibitory systemPlasma measuresUse disordersClinical practicePhasic changesConsecutive daysAlcohol usePsychological stressStroop performanceDisorder individualsDrinking controlsSymptomatologyImagery exposureCounterbalanced orderSymptomsDepression
2022
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic V, Sullivan L, Tiber J, Fogelman N, Simpson C, Hermes G, Sinha R. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. Psychopharmacology 2022, 240: 101-114. PMID: 36445398, PMCID: PMC10630889, DOI: 10.1007/s00213-022-06278-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDiastolic blood pressureHeart rateGABAergic transmissionNeuroactive steroidsHPA axisRelapse riskUse disordersAlcohol cravingTreatment of AUDAlcohol cue-induced cravingPilot clinical trialStress-induced anxietyCue-induced cravingAutonomic arousalNeurosteroid systemPreg groupStudy drugDBP responseBlood pressureDay groupClinical trialsPregnenolone levelsWeek 2Cue-provoked cravingBrain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents
Ottino‐González J, Garavan H, Albaugh M, Cao Z, Cupertino R, Schwab N, Spechler P, Allen N, Artiges E, Banaschewski T, Bokde A, Burke Quinlan E, Brühl R, Orr C, Cousijn J, Desrivières S, Flor H, Foxe J, Fröhner J, Goudriaan A, Gowland P, Grigis A, Heinz A, Hester R, Hutchison K, Li C, London E, Lorenzetti V, Luijten M, Nees F, Martín‐Santos R, Martinot J, Millenet S, Momenan R, Paillère Martinot M, Papadopoulos Orfanos D, Paulus M, Poustka L, Schmaal L, Schumann G, Sinha R, Smolka MN, Solowij N, Stein DJ, Stein EA, Uhlmann A, van Holst RJ, Veltman DJ, Walter H, Whelan R, Wiers RW, Yücel M, Zhang S, Jahanshad N, Thompson PM, Conrod P, Mackey S. Brain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents. Addiction 2022, 117: 1312-1325. PMID: 34907616, DOI: 10.1111/add.15772.Peer-Reviewed Original ResearchConceptsAlcohol dependenceHeavy drinking adolescentsStructural covariance networksAge 19Non-dependent controlsPre-existing risk factorsAge 14Cohort of adolescentsCross-sectional analysisRisk factorsAlcohol exposureEnhancing Neuroimaging GeneticsCortical thicknessHazardous drinkersEarly markerMeta-AnalysisNetwork segregationCross-sectional sampleIMAGEN studySubstantial exposureAdultsDrinking adolescentsCovariance networksBrain organizationAdolescentsAlcohol’s Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder
Sinha R. Alcohol’s Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder. Alcohol Research 2022, 42: 12. PMID: 36338609, PMCID: PMC9621746, DOI: 10.35946/arcr.v42.1.12.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disordersNational InstituteEvidence-based diagnosisIntramural Research ProgramAlcohol researchAlcohol-related problemsAlcohol abuseClinical researchMental healthTreatment researchStress neurobiologyDiagnosisPreventionDisordersNIAAAPresentationHealthAlcoholismInstitute
2013
Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R. Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk. JAMA Psychiatry 2013, 70: 727-739. PMID: 23636842, PMCID: PMC3788824, DOI: 10.1001/jamapsychiatry.2013.762.Peer-Reviewed Original ResearchConceptsHealthy control subjectsAD patientsControl subjectsInpatient treatmentAlcohol cravingAlcohol cuesBrain responsesRelapse riskAlcohol relapseHospital-based research unitAnterior cingulate cortex activationAlcohol-related cuesCommunity mental health centerVentromedial prefrontal functionChronic relapsing illnessVentromedial prefrontal cortexStress-induced cravingAbstinent alcohol-dependent patientsFunctional magnetic resonanceMental health centersAlcohol-dependent patientsSubsequent relapse riskNeural correlatesNeutral trialsHazard ratio
2011
Effects of Adrenal Sensitivity, Stress- and Cue-Induced Craving, and Anxiety on Subsequent Alcohol Relapse and Treatment Outcomes
Sinha R, Fox HC, Hong KI, Hansen J, Tuit K, Kreek MJ. Effects of Adrenal Sensitivity, Stress- and Cue-Induced Craving, and Anxiety on Subsequent Alcohol Relapse and Treatment Outcomes. JAMA Psychiatry 2011, 68: 942-952. PMID: 21536969, PMCID: PMC3668981, DOI: 10.1001/archgenpsychiatry.2011.49.Peer-Reviewed Original ResearchConceptsAlcohol-dependent patientsAlcohol relapseCue-induced alcohol cravingTreatment outcomesAdrenal sensitivityAlcohol cravingCommunity mental health centerCue-induced anxietyEarly alcohol recoveryHPA axis dysregulationHPA axis functionHPA axis responseMental health centersCue-induced alcoholAlcohol cuesStress-induced alcoholHospital-based research unitAlcohol-dependent individualsCue-Induced CravingCorticotropin levelsAxis dysregulationAxis functionAdrenal axisRelapse riskHealthy controls
2000
Alcohol and Eating Disorders: Implications for Alcohol Treatment and Health Services Research
Sinha R, O'Malley S. Alcohol and Eating Disorders: Implications for Alcohol Treatment and Health Services Research. Alcohol Clinical And Experimental Research 2000, 24: 1312-1319. PMID: 10968671, DOI: 10.1111/j.1530-0277.2000.tb02097.x.Peer-Reviewed Original ResearchConceptsHealth services research perspectivePossible etiologic associationAlcohol use disorderHealth services researchClinical manifestationsEtiologic associationAlcoholic womenPsychiatric disordersUse disordersAlcohol treatmentClinical implicationsBehavioral treatmentDisordersTreatment implicationsEating DisordersAlcoholismComorbiditiesWomenHigh rateServices researchSubstantial evidenceExpected ratesTreatmentReview
1999
Naturalistic Follow-Up of Drinking Behavior Following Participation in an Alcohol Administration Study
Sinha R, Krishnan-Sarin S, Farren C, O'Malley S. Naturalistic Follow-Up of Drinking Behavior Following Participation in an Alcohol Administration Study. Journal Of Substance Use And Addiction Treatment 1999, 17: 159-162. PMID: 10435264, DOI: 10.1016/s0740-5472(98)00058-0.Peer-Reviewed Original ResearchConceptsAlcohol administration researchAlcohol-dependent individualsSubsequent drinkingDrinking behaviorBrief motivational interventionAlcohol administration studyParticipants' drinking behaviorMotivational interventionIndividual motivationNumber of drinksAssessment of drinkingAdministration of alcoholAdministration researchSelf-administration studiesDrinking daysEffects of naltrexoneAlcohol dependenceParticipantsMotivationDrinkingIndividualsClinical benefitFollow-upBaseline levelsClinical need
1996
Eating Pathology among Women with Alcoholism and/ or Anxiety Disorders
Sinha R, Robinson J, Merikangas K, Wilson G, Rodin J, O'Malley S. Eating Pathology among Women with Alcoholism and/ or Anxiety Disorders. Alcohol Clinical And Experimental Research 1996, 20: 1184-1191. PMID: 8904968, DOI: 10.1111/j.1530-0277.1996.tb01109.x.Peer-Reviewed Original ResearchConceptsAnxiety disordersWeight concernsSchizophrenia-Lifetime VersionCo-morbid associationsEating Disorder ExaminationEating ConcernAlcoholic womenNonalcoholic womenDisorder NOSPsychiatric diagnosisAffective disordersBulimia nervosaDisorder ExaminationAlcoholismWomenDisordersHigher mean scoresCore psychopathologyMean scoreShape concernsHigh rateOvereatingEating Disorder Examination (EDE) subscalesScoresSubscales
1994
Assessment of recovery of electrophysiological and neurophysiological functions in chronic alcoholics
Glenn S, Parsons O, Sinha R. Assessment of recovery of electrophysiological and neurophysiological functions in chronic alcoholics. Biological Psychiatry 1994, 36: 443-452. PMID: 7811840, DOI: 10.1016/0006-3223(94)90639-4.Peer-Reviewed Original Research
1993
Electrophysiological indices predict resumption of drinking in sober alcoholics
Glenn S, Sinha R, Parsons O. Electrophysiological indices predict resumption of drinking in sober alcoholics. Alcohol 1993, 10: 89-95. PMID: 8442897, DOI: 10.1016/0741-8329(93)90086-4.Peer-Reviewed Original ResearchConceptsInpatient alcoholism treatment programResumption of drinkingInitial testing sessionAlcoholism treatment programSocial predictor variablesChronic alcoholicsEvent-related potentialsMultivariate analysisSober alcoholicsTreatment programNonalcoholic controlsDrinking patternsN200 latencyAlcoholicsChi 2Biopsychosocial modelP300 amplitudeTesting sessionsStimulus taskElectrophysiological indices
1990
Relationships between Neuropsychological Test Performance and Event‐Related Potentials in Alcoholic and Nonalcoholic Samples
Parsons O, Sinha R, Williams H. Relationships between Neuropsychological Test Performance and Event‐Related Potentials in Alcoholic and Nonalcoholic Samples. Alcohol Clinical And Experimental Research 1990, 14: 746-755. PMID: 2264605, DOI: 10.1111/j.1530-0277.1990.tb01239.x.Peer-Reviewed Original ResearchConceptsEvent-related potentialsNeuropsychological test performanceTest performanceEvent-related potential taskPerceptual-motor testsFamily history positive alcoholicsERP differencesMiddle-aged alcoholicsERP measuresERP responsesP3 amplitudeNeuropsychological testsP3 latencyERP variablesPM testNP measuresPeer controlsNP performanceFemale alcoholicsSober alcoholicsNonalcoholic samplesMale alcoholicsPotential tasksMental disordersNP test
1989
The Relationship Between Neuropsychological and Late Component Evoked Potential Measures in Chronic Alcoholics
Patterson B, Sinha R, Williams H, Parsons O, Smith L, Schaeffer K. The Relationship Between Neuropsychological and Late Component Evoked Potential Measures in Chronic Alcoholics. International Journal Of Neuroscience 1989, 49: 319-327. PMID: 2638354, DOI: 10.3109/00207458909084830.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBrainElectroencephalographyHumansMaleMiddle AgedNeuropsychological TestsConceptsPerceptual-motor testsERP measuresFigural memoryNeuropsychological measuresMemory scoresEvent-related potential (ERP) measuresPerceptual-motor functionPerceptual-motor functioningVisual P3 amplitudePotential measuresEvoked potential measuresP3 amplitudeNd amplitudesP3 componentN1 amplitudeNeuropsychological testsCorrelational analysisMemoryAge-matched male controlsMeasuresSignificant relationshipSignificant correlationMale alcoholicsAlcoholicsNeuropsychologicalDrinking variables, affective measures and neuropsychological performance: Familial alcoholism and gender correlates
Sinha R, Parsons O, Glenn S. Drinking variables, affective measures and neuropsychological performance: Familial alcoholism and gender correlates. Alcohol 1989, 6: 77-85. PMID: 2719819, DOI: 10.1016/0741-8329(89)90077-3.Peer-Reviewed Original ResearchConceptsDrinking variablesNeuropsychological performance scoresFamily history-negative (FH-) alcoholicsNeuropsychological test performanceAlcohol intake measuresCognitive functioningNeuropsychological measuresAlcohol consumption variablesAffective measuresFemale alcoholicsNeuropsychological performanceTest performanceDepression Inventory scoresAffective symptomatologyAnxiety scoresBeck Depression Inventory scoresImpairment IndexFamilial alcoholismInventory scoresPerformance scoresIntake measuresMeasuresSignificant relationshipGender correlatesAlcohol consumption