2015
Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome
Huffman JC, Beale EE, Celano CM, Beach SR, Belcher AM, Moore SV, Suarez L, Motiwala SR, Gandhi PU, Gaggin HK, Januzzi JL. Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome. Circulation Cardiovascular Quality And Outcomes 2015, 9: 55-63. PMID: 26646818, PMCID: PMC4720551, DOI: 10.1161/circoutcomes.115.002184.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePhysical activityBaseline optimismCardiac readmissionACS patientsCoronary syndromeMultivariable Cox regressionSubsequent physical activityGreater physical activityMultivariable linear regressionBeneficial health outcomesPositive psychological constructsCardiac rehospitalizationCardiovascular outcomesMedical comorbiditiesClinical outcomesCox regressionACS outcomesPrognostic biomarkerHealth outcomesBaseline activityPsychological covariatesReadmissionBiomarkersEffects of optimismDiagnostic and Prognostic Utility of Procalcitonin in Patients Presenting to the Emergency Department with Dyspnea
Alba GA, Truong QA, Gaggin HK, Gandhi PU, De Berardinis B, Magrini L, Bajwa EK, Di Somma S, Januzzi JL, Network G. Diagnostic and Prognostic Utility of Procalcitonin in Patients Presenting to the Emergency Department with Dyspnea. The American Journal Of Medicine 2015, 129: 96-104.e7. PMID: 26169892, DOI: 10.1016/j.amjmed.2015.06.037.Peer-Reviewed Original ResearchConceptsDiagnosis of pneumoniaNet reclassification improvementEmergency departmentHeart failurePrognostic valueReclassification improvementEmergency department patientsIndependent prognostic informationAccuracy of procalcitoninUrban emergency departmentAccurate diagnostic markerAcute dyspneaClinician certaintyElevated procalcitoninSerum procalcitoninDyspneic patientsProspective cohortSecondary outcomesDepartment patientsProcalcitonin concentrationsFatal outcomeNatriuretic peptidePCT valuesPrognostic utilityPatient population
2014
Characterization and Prediction of Adverse Events From Intensive Chronic Heart Failure Management and Effect on Quality of Life: Results From the Pro-B-Type Natriuretic Peptide Outpatient-Tailored Chronic Heart Failure Therapy (PROTECT) Study
Gandhi PU, Szymonifka J, Motiwala SR, Belcher AM, Januzzi JL, Gaggin HK. Characterization and Prediction of Adverse Events From Intensive Chronic Heart Failure Management and Effect on Quality of Life: Results From the Pro-B-Type Natriuretic Peptide Outpatient-Tailored Chronic Heart Failure Therapy (PROTECT) Study. Journal Of Cardiac Failure 2014, 21: 9-15. PMID: 25463415, DOI: 10.1016/j.cardfail.2014.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersCardiovascular AgentsChronic DiseaseDisease ManagementDizzinessFemaleHeart FailureHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsPredictive Value of TestsProspective StudiesQuality of LifeRenal InsufficiencySurveys and QuestionnairesTreatment OutcomeConceptsTreatment-related serious adverse eventsSerious adverse eventsQuality of lifeAdverse eventsRisk scoreN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideChronic heart failure managementHeart Failure Questionnaire scoreWorse QOLAcute renal failureFirst cardiovascular eventHeart failure managementHeart failure therapyWorse functional classHighest-risk quartileCare armHF careHF managementSystolic HFCardiovascular eventsNT-proBNPReverse remodelingFailure therapyRenal failurePrognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function?
Gandhi PU, Gaggin HK, Sheftel AD, Belcher AM, Weiner RB, Baggish AL, Motiwala SR, Liu PP, Januzzi JL. Prognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function? The American Journal Of Cardiology 2014, 114: 1543-1549. PMID: 25248814, DOI: 10.1016/j.amjcard.2014.08.018.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersDisease ProgressionEchocardiography, DopplerFemaleFollow-Up StudiesHeart Failure, DiastolicHumansInsulin-Like Growth Factor Binding ProteinsMaleMiddle AgedMyocardial ContractionPrognosisProspective StudiesSeverity of Illness IndexStroke VolumeTime FactorsVentricular Function, LeftConceptsInsulin-like growth factor-binding protein 7Right ventricular systolic pressureReduced ejection fractionAtrial volume indexVentricular systolic pressureTransmitral E/Diastolic functionIGFBP7 concentrationsHeart failureEjection fractionSystolic pressureVolume indexEchocardiographic parametersHigher left atrial volume indexLeft atrial volume indexInsulin-like growth factorAmbulatory heart failureAbnormal diastolic functionMyocardial diastolic functionNovel prognostic biomarkerProtein 7Binding protein 7Echocardiographic abnormalitiesFinal echocardiogramCardiovascular events