2017
A translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia
Gunduz‐Bruce H, Kenney J, Changlani S, Peixoto A, Gueorguieva R, Leone C, Stachenfeld N. A translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2017, 102: 587-597. PMID: 28294453, DOI: 10.1113/ep086212.Peer-Reviewed Original ResearchConceptsSubgroup of patientsHealthy control subjectsNMDA receptorsControl subjectsDepressed patientsAVP releaseAnimal studiesSchizophrenic subjectsTranslational approachVivo evidenceRecent clinical trialsNMDA receptor functionPlasma arginine vasopressin concentrationNMDA receptor activityHypertonic saline infusionNMDA antagonist ketamineArginine vasopressin concentrationHypertonic salineInverse associationClinical trialsHealthy controlsSaline infusionGlutamate signalingSchizophrenic patientsVasopressin concentration
2008
Sex Hormone Effects on Body Fluid Regulation
Stachenfeld NS. Sex Hormone Effects on Body Fluid Regulation. Exercise And Sport Sciences Reviews 2008, 36: 152-159. PMID: 18580296, PMCID: PMC2849969, DOI: 10.1097/jes.0b013e31817be928.Peer-Reviewed Original Research
2003
Oestrogen effects on urine concentrating response in young women
Stachenfeld NS, Taylor HS, Leone CA, Keefe DL. Oestrogen effects on urine concentrating response in young women. The Journal Of Physiology 2003, 552: 869-880. PMID: 12923212, PMCID: PMC2343447, DOI: 10.1113/jphysiol.2003.046920.Peer-Reviewed Original ResearchConceptsAVP infusionRenal sensitivityHormone treatmentDistal tubular sodium reabsorptionRenal free water clearanceRenal fluid retentionTubular sodium reabsorptionFree water clearancePlasma AVP concentrationArginine vasopressin releaseRate of clearancePhysiological rangeOE2 treatmentSodium excretionGnRHa administrationSodium reabsorptionEstrogen effectsEstrogen treatmentFluid retentionLeuprolide acetateWater clearanceRenal waterAVP concentrationVasopressin releaseUrine osmolality
2002
Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. AJP Endocrinology And Metabolism 2002, 283: e711-e721. PMID: 12217888, DOI: 10.1152/ajpendo.00192.2002.Peer-Reviewed Original ResearchConceptsHormone treatmentEstrogen effectsPlasma renin activityFree water clearanceEnd of recoveryIntrarenal effectsRenal sensitivityRenin activitySodium excretionFractional excretionAVP increaseSodium retentionFluid retentionLeuprolide acetateWater clearanceEndogenous estrogensAldosterone stimulationFluid balanceGnRHaNaCl infusionPg/EstrogenAVPProgesteroneExcretion
2001
Progesterone does not alter osmotic regulation of AVP
Calzone W, Silva C, Keefe D, Stachenfeld N. Progesterone does not alter osmotic regulation of AVP. AJP Regulatory Integrative And Comparative Physiology 2001, 281: r2011-r2020. PMID: 11705788, DOI: 10.1152/ajpregu.2001.281.6.r2011.Peer-Reviewed Original ResearchConceptsHypertonic saline infusionLuteal phaseOral contraceptivesFollicular phaseOsmotic thresholdThirst onsetRenal free water clearanceLow osmotic thresholdFree water clearancePlasma AVP concentrationArginine vasopressin releaseBaseline plasma osmolalityBody water balanceMenstrual cycleMidluteal phaseWater clearanceSaline infusionAVP releaseAVP concentrationMenstrual phaseVasopressin releaseFluid balanceOC treatmentThirst responseCrossover designSelected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling
Stachenfeld N, Splenser A, Calzone W, Taylor M, Keefe D. Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling. Journal Of Applied Physiology 2001, 91: 1893-1901. PMID: 11568177, DOI: 10.1152/jappl.2001.91.4.1893.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureMenstrual phaseBasal plasma AVP concentrationGreater systolic blood pressurePressure-natriuresis curveRenal sodium handlingPlasma osmolalityPlasma AVP concentrationMin of restMidluteal menstrual phasesBasal plasma osmolalitySex differencesSodium handlingPulse pressureBody wtAVP concentrationAVP releaseNaCl infusionHormone responseMenWomenGreater sensitivityBody waterOsmolality
1999
Effects of oral contraceptives on body fluid regulation
Stachenfeld N, Silva C, Keefe D, Kokoszka C, Nadel E. Effects of oral contraceptives on body fluid regulation. Journal Of Applied Physiology 1999, 87: 1016-1025. PMID: 10484572, DOI: 10.1152/jappl.1999.87.3.1016.Peer-Reviewed Original ResearchConceptsBody fluid regulationLuteal phaseHighest plasma estradiol concentrationFluid regulationOral contraceptive administrationBody fluid retentionPlasma estradiol concentrationsMidluteal menstrual phasesBody fluid balanceArginine vasopressin concentrationBasal plasma osmolalityExercise dehydrationOral contraceptivesContraceptive administrationBody water balanceFluid retentionFollicular phaseEstradiol concentrationsAVP releaseMenstrual phaseFluid balanceVasopressin concentrationCrossover designThirst stimulationPlasma osmolalityPhysiological variability of fluid-regulation hormones in young women
Stachenfeld N, DiPietro L, Kokoszka C, Silva C, Keefe D, Nadel E. Physiological variability of fluid-regulation hormones in young women. Journal Of Applied Physiology 1999, 86: 1092-1096. PMID: 10066728, DOI: 10.1152/jappl.1999.86.3.1092.Peer-Reviewed Original ResearchConceptsPlasma renin activityEarly follicular phaseFollicular phaseMenstrual phaseMenstrual phase-related differencesAtrial natriuretic peptideDifferent menstrual phasesMean hormone concentrationsRenin activityNatriuretic peptideMidluteal phaseMenstrual cycleHormonal variablesPlasma concentrationsLuteal phaseHormone concentrationsPhase-related differencesYoung womenHormoneCronbach's alphaRehydration periodRestingAlphaMean concentrationPhysiological variability
1998
Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women
Stachenfeld N, Dipietro L, Palter S, Nadel E. Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. American Journal Of Physiology 1998, 274: r187-r195. PMID: 9458917, DOI: 10.1152/ajpregu.1998.274.1.r187.Peer-Reviewed Original ResearchConceptsMin of drinkingPg/Body water balanceHypertonic salineFractional sodium excretionPlasma aldosterone concentrationRenal sodium reabsorptionFree water clearancePlasma estradiol concentrationsHypertonic saline infusionHigh E2 statesWater ad libitumMosmol/kgH2OAldosterone concentrationPostmenopausal womenSodium excretionPlacebo administrationUrine outputAVP secretionSodium reabsorptionFluid retentionE2 treatmentEstradiol concentrationsWater clearanceSaline infusion
1995
Body temperature modification of osmotically induced vasopressin secretion and thirst in humans
Takamata A, Mack G, Stachenfeld N, Nadel E. Body temperature modification of osmotically induced vasopressin secretion and thirst in humans. American Journal Of Physiology 1995, 269: r874-r880. PMID: 7485606, DOI: 10.1152/ajpregu.1995.269.4.r874.Peer-Reviewed Original Research