Featured Publications
Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement
Knauert M, Ayas N, Bosma K, Drouot X, Heavner M, Owens R, Watson P, Wilcox M, Anderson B, Cordoza M, Devlin J, Elliott R, Gehlbach B, Girard T, Kamdar B, Korwin A, Lusczek E, Parthasarathy S, Spies C, Sunderram J, Telias I, Weinhouse G, Zee P. Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2023, 207: e49-e68. PMID: 36999950, PMCID: PMC10111990, DOI: 10.1164/rccm.202301-0184st.Peer-Reviewed Original ResearchMorning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotypeKeeping an eye on circadian time in clinical research and medicine
Klerman E, Brager A, Carskadon M, Depner C, Foster R, Goel N, Harrington M, Holloway P, Knauert M, LeBourgeois M, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer F, Shea S, Skene D, Spies C, Staels B, St‐Onge M, Tiedt S, Zee P, Burgess H. Keeping an eye on circadian time in clinical research and medicine. Clinical And Translational Medicine 2022, 12: e1131. PMID: 36567263, PMCID: PMC9790849, DOI: 10.1002/ctm2.1131.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Adding Insult to Injury Sleep Deficiency in Hospitalized Patients
Mansour W, Knauert M. Adding Insult to Injury Sleep Deficiency in Hospitalized Patients. Sleep Medicine Clinics 2024, 19: 607-623. PMID: 39455181, DOI: 10.1016/j.jsmc.2024.07.008.Peer-Reviewed Original ResearchConceptsHospital settingSleep promotion protocolsSleep deficiencyHospitalized patientsNegative health effectsObjective sleep measuresSleep measurement techniquesHospital outcomesMedical conditionsEffects of sleep deficiencyStudy protocolIllness severitySleep promotionHospital environmentImpact multiple organ systemsMultiple organ systemsHospitalTreatment-related effectsSleep measuresContributing factorsPromotion protocolOrgan systemsOutcomesPatientsSleepFeeding critically ill patients at the right time of day
Dashti H, Wang Y, Knauert M. Feeding critically ill patients at the right time of day. Critical Care 2024, 28: 206. PMID: 38915028, PMCID: PMC11197374, DOI: 10.1186/s13054-024-04994-0.Peer-Reviewed Original ResearchEarly goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study
Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.Peer-Reviewed Original ResearchConceptsEarly enteral nutritionIn-hospital deathCritically ill adultsRetrospective cohort studyDays of intubationEnteral nutritionIll adultsAdult patientsCohort studyAssociated with decreased in-hospital deathsMechanically ventilated critically ill adultsGoal enteral nutritionIncreased hospital dischargeInitiation of ENCritically ill adult patientsMechanically ventilated adult patientsIncidence of in-hospital deathMedical intensive care unitAssociated with significant improvementsIll adult patientsDose of ENIntensive care unitClinical outcomesImprove mortalityPrimary outcome
2022
Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition
Miner B, Doyle M, Knauert M, Yaggi H, Stone K, Ancoli‐Israel S, Cauley J, Redline S, Blackwell T, Gill T, Groups F. Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition. Journal Of The American Geriatrics Society 2022, 71: 1198-1208. PMID: 36524599, PMCID: PMC10089942, DOI: 10.1111/jgs.18195.Peer-Reviewed Original ResearchConceptsShort sleep durationObjective short sleep durationCommunity-living older personsSleep durationOsteoporotic fracturesOlder menCommunity-living older menOlder personsMultiple predisposingHealth conditionsMen Sleep StudyModifiable risk factorsSeparate logistic regression modelsPoor sleep qualityHigh-risk phenotypeCross-sectional studyCross-sectional associationsMiddle-aged personsLogistic regression modelsClinical correlatesRisk factorsMultivariable modelSleep studiesSleep qualityOlder womenAdding Insult to Injury Sleep Deficiency in Hospitalized Patients
Mansour W, Knauert M. Adding Insult to Injury Sleep Deficiency in Hospitalized Patients. Clinics In Chest Medicine 2022, 43: 287-303. PMID: 35659026, PMCID: PMC9177053, DOI: 10.1016/j.ccm.2022.02.009.Peer-Reviewed Original ResearchConceptsSleep deficiencyHospital settingTreatment-related effectsMultiple organ systemsObjective sleep measurementsHospital outcomesHospitalized patientsIllness severityNegative health effectsSleep promotionStudy protocolPromotion protocolMedical conditionsSleep measurementsKey next stepOrgan systemsHealth effectsHospital environmentPatientsContributing factorDeficiencyOutcomesCommon problemInsultSettingSleep Deficiency and Health
Knauert MP. Sleep Deficiency and Health. Clinics In Chest Medicine 2022, 43: xiii-xiv. PMID: 35659032, DOI: 10.1016/j.ccm.2022.02.014.Peer-Reviewed Original ResearchEnhancing cosinor analysis of circadian phase markers using the gamma distribution
Doyle MM, Murphy TE, Miner B, Pisani MA, Lusczek ER, Knauert MP. Enhancing cosinor analysis of circadian phase markers using the gamma distribution. Sleep Medicine 2022, 92: 1-3. PMID: 35306404, PMCID: PMC9356385, DOI: 10.1016/j.sleep.2022.01.015.Peer-Reviewed Original Research
2021
Influence of medical trainee sleep pattern (chronotype) on burn-out and satisfaction with work schedules: a multicentre observational study
Gohar A, Knauert M, Kalot M, Khan A, Sider D, Javed M, Wooldridge D, Eck L, Buckhold F, Colaco B, Bhat A, Castillo D, Newman R, Mustafa R. Influence of medical trainee sleep pattern (chronotype) on burn-out and satisfaction with work schedules: a multicentre observational study. Postgraduate Medical Journal 2021, 98: 936-941. PMID: 37062998, PMCID: PMC10074556, DOI: 10.1136/postgradmedj-2021-140975.Peer-Reviewed Original ResearchA SAS macro for modelling periodic data using cosinor analysis
Doyle MM, Murphy TE, Pisani MA, Yaggi HK, Jeon S, Redeker NS, Knauert MP. A SAS macro for modelling periodic data using cosinor analysis. Computer Methods And Programs In Biomedicine 2021, 209: 106292. PMID: 34380075, PMCID: PMC8435001, DOI: 10.1016/j.cmpb.2021.106292.Peer-Reviewed Original Research
2020
A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the Future
Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the Future. CHEST Journal 2020, 159: 949-958. PMID: 33159907, PMCID: PMC7641526, DOI: 10.1016/j.chest.2020.10.067.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute diseaseRespiratory syndromeSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Post-intensive care syndromePotential long-term complicationsCOVID-19Respiratory syndrome coronavirus 2Middle East respiratory syndromeSevere acute respiratory syndromeCoronavirus disease 2019 (COVID-19) casesPersistent respiratory symptomsLong-term complicationsCOVID-19 survivorsSyndrome coronavirus 2Acute respiratory syndromeCOVID-19 outcomesChronic complicationsPersistent symptomsRespiratory symptomsCoronavirus 2Lung diseaseNonhospitalized individualsClinical programsComplications
2019
Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes
Gao C, Knauert M. Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes. Seminars In Respiratory And Critical Care Medicine 2019, 40: 629-637. PMID: 31826263, DOI: 10.1055/s-0039-1698394.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIll patientsIntensive care unit careIntensive care unit practiceCircadian rhythmCurrent ICU practiceLow-risk interventionNumerous adverse outcomesUnit careCritical illnessImmune compromiseCardiovascular instabilityMetabolic derangementsAdverse outcomesICU practiceUnit practicesSleep disruptionCare improvementPatientsOutcomesSleepRhythmBright lightDaysCircadian biologyDeliriumPilot study: an intensive care unit sleep promotion protocol
Knauert MP, Pisani M, Redeker N, Murphy T, Araujo K, Jeon S, Yaggi H. Pilot study: an intensive care unit sleep promotion protocol. BMJ Open Respiratory Research 2019, 6: e000411. PMID: 31258916, PMCID: PMC6561389, DOI: 10.1136/bmjresp-2019-000411.Peer-Reviewed Original ResearchConceptsPromotion protocolProtocol armUsual careSleep protocolICU sleepProtocol patientsIll patientsPrimary outcomeSleep disruptionBedside careRoom entryPatientsRoom activitiesSleep opportunityCareLength of timeProtocol effectMean ARoom disturbancesGeneralised linear modelArmTime blocksEquivalent levelsRoom entranceActivity
2018
Association between death and loss of stage N2 sleep features among critically Ill patients with delirium
Knauert MP, Gilmore EJ, Murphy TE, Yaggi HK, Van Ness PH, Han L, Hirsch LJ, Pisani MA. Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. Journal Of Critical Care 2018, 48: 124-129. PMID: 30179762, PMCID: PMC6226351, DOI: 10.1016/j.jcrc.2018.08.028.Peer-Reviewed Original ResearchConceptsICU patientsIll patientsOdds ratioHigher oddsSleep spindlesIntensive care unit outcomesGrade of encephalopathySignificant sleep disruptionWorse ICU outcomeMedical ICU patientsAcute brain injuryObservational cohort studySedative-hypnotic useImportant prognostic valueLength of stayStage N2 sleepK-complexesCohort studyCritical illnessHospital dischargeRankin ScaleICU outcomesPrognostic valueSevere gradesMedical recordsNon-circadian signals in the intensive care unit: Point prevalence morning, noon and night
Altman MT, Pulaski C, Mburu F, Pisani MA, Knauert MP. Non-circadian signals in the intensive care unit: Point prevalence morning, noon and night. Heart & Lung 2018, 47: 610-615. PMID: 30143362, PMCID: PMC6234066, DOI: 10.1016/j.hrtlng.2018.07.011.Peer-Reviewed Original ResearchConceptsSleep promotion interventionsIntensive care unitICU patient roomsQuality improvement initiativesCare unitSleep disturbancesObservational studyICU roomAbnormal lightPatient roomsSound exposureImprovement initiativesDoor curtainsInterventionPrevalenceEnvironmental factorsBright lightRoom doorICUFactors
2017
Factors Influencing Patients' Sleep in the Intensive Care Unit: Perceptions of Patients and Clinical Staff.
Ding Q, Redeker NS, Pisani MA, Yaggi HK, Knauert MP. Factors Influencing Patients' Sleep in the Intensive Care Unit: Perceptions of Patients and Clinical Staff. American Journal Of Critical Care 2017, 26: 278-286. PMID: 28668912, PMCID: PMC5559223, DOI: 10.4037/ajcc2017333.Peer-Reviewed Original ResearchConceptsIntensive care unitMedical intensive care unitPatients' sleepCare unitSleep improvementIntensive care unit staffIntensive care unit environmentPerceptions of patientsAdequate sleep opportunityIll patientsBeliefs of staffClinical outcomesSleep qualityRestorative sleepUnit staffPatientsClinical staffPatient surrogatesSleepUnit environmentSleep opportunityOnly factorPatients' emotionsNonenvironmental factorsSemistructured interviewsSleep Disturbance after Hospitalization and Critical Illness: A Systematic Review
Altman MT, Knauert MP, Pisani MA. Sleep Disturbance after Hospitalization and Critical Illness: A Systematic Review. Annals Of The American Thoracic Society 2017, 14: 1457-1468. PMID: 28644698, PMCID: PMC5711402, DOI: 10.1513/annalsats.201702-148sr.BooksConceptsCritical illnessHospital dischargeSleep disturbancesRisk factorsSystematic reviewIntensive care unit admissionCare unit admissionIll adult patientsTime pointsCritical illness survivorsObjective sleep parametersQuestionnaire studyUnit admissionAdult patientsHospital factorsIll patientsPrimary outcomePrehospital factorsImpaired qualityObjective measurement toolsPsychological comorbiditiesAbnormal sleepMultiple time pointsPolysomnography studiesPoor sleep
2016
Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers
Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.Peer-Reviewed Original ResearchConceptsPoor sleepICU outcomesProviders' perceptionsIntensive care unit outcomesAvailable evidence-based guidelinesDevelopment of deliriumIntensive care unitEvidence-based guidelinesCritical care providersBetter sleep qualityMinority of providersICU surveyICU patientsIll patientsCare unitMechanical ventilationICU providersPatient outcomesRecent guidelinesPhysical therapyMost cliniciansPromotion protocolSleep qualityCare providersICU