2016
Dexmedetomidine for hyperactive delirium: worth further study
Knauert MP, Pisani MA. Dexmedetomidine for hyperactive delirium: worth further study. Journal Of Thoracic Disease 2016, 8: e999-e1002. PMID: 27747045, PMCID: PMC5059358, DOI: 10.21037/jtd.2016.08.14.Commentaries, Editorials and LettersRisk factorsIntensive care unit patientsLength of ICUHistory of hypertensionCare unit patientsManagement of painPre-existing dementiaSeverity of illnessClinical practice guidelinesCritical care issuesHigher healthcare costsHistory of alcoholismLong-term cognitionPoor ICU outcomesCritical care medicineICU incidenceICU medicationsIntravenous haloperidolHospital stayHyperactive deliriumICU deliriumAdult patientsUnit patientsMechanical ventilationICU outcomes
2015
Awake or Sedated: Trends in the Evaluation and Management of Agitation in the Intensive Care Unit
DeBiasi EM, Akgün KM, Pisani M. Awake or Sedated: Trends in the Evaluation and Management of Agitation in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2015, 36: 899-913. PMID: 26595050, DOI: 10.1055/s-0035-1564875.BooksConceptsICU patientsSedation practicesIll intensive care unit (ICU) patientsIntensive care unit patientsSedation assessment scaleMechanical ventilation durationCare unit patientsManagement of agitationMost ICU patientsIntensive care unitImproved clinical outcomesMultidisciplinary treatment modelLife-saving interventionsHospital lengthMinimal sedationSedative medicationsUnit patientsCare unitClinical outcomesMechanical ventilationVentilation durationPatient distressFunctional impairmentPractice guidelinesPatient discomfortSleep in the Intensive Care Unit
Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF. Sleep in the Intensive Care Unit. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 731-738. PMID: 25594808, PMCID: PMC5447310, DOI: 10.1164/rccm.201411-2099ci.Peer-Reviewed Original ResearchConceptsCritical illnessIntensive care unit patientsConcise clinical reviewCare unit patientsIntensive care unitPatient care activitiesCircadian rhythm abnormalitiesCircadian rhythmImportant physiologic processesLack of sleepUnit patientsICU patientsPatients' sleepCare unitClinical reviewAdverse outcomesSleep disturbancesRhythm abnormalitiesRole sleepCare activitiesIllnessClinical researchSleepPatientsPhysiologic processesHealth care worker attitudes and identified barriers to patient sleep in the medical intensive care unit
Hopper K, Fried TR, Pisani MA. Health care worker attitudes and identified barriers to patient sleep in the medical intensive care unit. Heart & Lung 2015, 44: 95-99. PMID: 25686516, PMCID: PMC5632814, DOI: 10.1016/j.hrtlng.2015.01.011.Peer-Reviewed Original ResearchConceptsHealth care workers' attitudesCare workers' attitudesPatients' sleepMedical intensive care unitIntensive care unit patientsCare unit patientsIntensive care unitSystem-based barriersSignificance of sleepICU careUnit patientsCare unitSleep promotionICU policyMultiple environmental barriersSleep disruptionQualitative studyICUSleepNight shiftsLack of consensusWorkers' attitudesAttitudinal barriersAdditional targetsEnvironmental barriers
2014
Feasibility study of unattended polysomnography in medical intensive care unit patients
Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart & Lung 2014, 43: 445-452. PMID: 25023504, PMCID: PMC4150840, DOI: 10.1016/j.hrtlng.2014.06.049.Peer-Reviewed Original ResearchConceptsMedical intensive care unitPortable polysomnographySleep efficiencyMedical intensive care unit patientsIntensive care unit patientsSleep deprivationOvernight sleep durationCare unit patientsObservational pilot studyIntensive care unitIndicators of feasibilityUnattended polysomnographyUnit patientsIll patientsPatients' sleepCare unitArousal indexPSG studiesSleep durationPatientsInterpretable qualityPilot studyGold standardSleepSleep stagesThe prevalence of undiagnosed diabetes mellitus and the association of baseline glycemic control on mortality in the intensive care unit: A prospective observational study
Hoang QN, Pisani MA, Inzucchi S, Hu B, Honiden S. The prevalence of undiagnosed diabetes mellitus and the association of baseline glycemic control on mortality in the intensive care unit: A prospective observational study. Journal Of Critical Care 2014, 29: 1052-1056. PMID: 25092614, DOI: 10.1016/j.jcrc.2014.06.007.Peer-Reviewed Original ResearchConceptsBaseline glycemic controlStress hyperglycemiaGlycemic controlUndiagnosed diabetesChronic Health Evaluation II scoreMedical intensive care unit patientsIntensive care unit patientsHemoglobin A1c levelsHistory of diabetesObservational cohort studyProspective observational studyUndiagnosed diabetes mellitusCare unit patientsIntensive care unitLower baseline HbA1cMultivariable logistic regressionSignificant differencesAcute PhysiologyHospital mortalityNondiabetic patientsBaseline HbA1cII scoreMICU patientsCohort studyCritical illness
2010
Does Gender Impact Intensity of Care Provided to Older Medical Intensive Care Unit Patients?
Akgün KM, Murphy TE, Araujo KL, Van Ness PH, Pisani M. Does Gender Impact Intensity of Care Provided to Older Medical Intensive Care Unit Patients? Critical Care Research And Practice 2010, 2010: 404608. PMID: 20981259, PMCID: PMC2964007, DOI: 10.1155/2010/404608.Peer-Reviewed Original ResearchMedical intensive care unitTISS-28 scoresMICU interventionMICU patientsMICU admissionTISS-28Medical intensive care unit patientsTherapeutic Intervention Scoring System-28Intensive care unit patientsUrban university teaching hospitalAggressive critical careChronic respiratory failureCare unit patientsIntensive care unitUniversity Teaching HospitalCritical care literatureEquivalence of careLevel of careRespiratory failureProspective cohortUnit patientsPrimary outcomeCare unitTeaching hospitalCritical care
2009
Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population
Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population. American Journal Of Respiratory And Critical Care Medicine 2009, 180: 1092-1097. PMID: 19745202, PMCID: PMC2784414, DOI: 10.1164/rccm.200904-0537oc.Peer-Reviewed Original ResearchConceptsICU deliriumPatient populationNumber of daysOlder intensive care unit patientsIntensive care unit populationAdverse long-term outcomesIntensive care unit patientsRelevant covariatesUrban acute care hospitalDuration of deliriumPost-ICU admissionConfusion Assessment MethodOlder patient populationProspective cohort studyCare unit patientsSeverity of illnessLong-term outcomesDays of deliriumPsychoactive medication useAcute care hospitalsChart review methodImportant health outcomesICU admissionCohort studyICU populationBenzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*
Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*. Critical Care Medicine 2009, 37: 177-183. PMID: 19050611, PMCID: PMC2700732, DOI: 10.1097/ccm.0b013e318192fcf9.Peer-Reviewed Original ResearchConceptsModifiable risk factorsICU deliriumDelirium durationOpioid useRisk factorsFirst episodeMedical intensive care unit patientsIntensive care unit deliriumMedical intensive care unitIntensive care unit patientsUrban university teaching hospitalConfusion Assessment MethodProspective cohort studyCare unit patientsSeverity of illnessIntensive care unitUniversity Teaching HospitalMain outcome measuresUse of benzodiazepinesChart review methodMultivariable regression modelsImpact of benzodiazepinesCohort studyMedian durationUnit patients
2008
Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient
Pisani MA. Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient. Journal Of Intensive Care Medicine 2008, 24: 83-95. PMID: 19114416, DOI: 10.1177/0885066608329942.Peer-Reviewed Original ResearchConceptsOlder patientsPhysiologic changesOlder intensive care unit patientsIntensive care unit admissionIntensive care unit patientsIll Older PatientsImportant physiologic changesOlder ICU patientsCare unit admissionCare unit patientsDevelopment of sepsisSeverity of illnessUnit admissionCritical illnessUnit patientsICU patientsPoor outcomeAdverse outcomesRisk factorsCritical careOutcome studiesChronologic agePatientsAge 65Sepsis
2005
Short-term outcomes in older intensive care unit patients with dementia*
Pisani MA, Redlich CA, McNicoll L, Ely EW, Friedkin RJ, Inouye SK. Short-term outcomes in older intensive care unit patients with dementia*. Critical Care Medicine 2005, 33: 1371-1376. PMID: 15942358, DOI: 10.1097/01.ccm.0000165558.83676.48.Peer-Reviewed Original ResearchConceptsICU interventionsOlder patientsModerate-severe dementiaPatient ageCode statusMortality rateChronic Health Evaluation II scoreOlder intensive care unit patientsProspective observational cohort studyIntensive care unit careIntensive care unit patientsUrban university teaching hospitalShort-term mortality rateBlessed Dementia Rating ScaleHigher Acute PhysiologyHospital mortality rateObservational cohort studyCare unit patientsMedical record abstractionShort-term outcomesUniversity Teaching HospitalDementia Rating ScaleImpact of dementiaAcute PhysiologyHospital length
2003
Screening for Preexisting Cognitive Impairment in Older Intensive Care Unit Patients: Use of Proxy Assessment
Pisani MA, Inouye SK, McNicoll L, Redlich CA. Screening for Preexisting Cognitive Impairment in Older Intensive Care Unit Patients: Use of Proxy Assessment. Journal Of The American Geriatrics Society 2003, 51: 689-693. PMID: 12752846, DOI: 10.1034/j.1600-0579.2003.00215.x.Peer-Reviewed Original ResearchConceptsMedical intensive care unitIntensive care unitCognitive impairmentOlder intensive care unit patientsIntensive care unit patientsUrban university teaching hospitalCross-sectional comparative studyBlessed Dementia Rating ScaleDirect patient assessmentPreexisting Cognitive ImpairmentCare unit patientsUniversity Teaching HospitalPatient care decisionsDementia Rating ScaleUnit patientsICU patientsCare unitPatient assessmentPhysician recognitionTeaching hospitalHigh prevalencePatientsInformant QuestionnaireCognitive declineProxy measureDelirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients
McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK. Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients. Journal Of The American Geriatrics Society 2003, 51: 591-598. PMID: 12752832, DOI: 10.1034/j.1600-0579.2003.00201.x.Peer-Reviewed Original ResearchConceptsConfusion Assessment MethodOccurrence of deliriumPost-ICU periodICU stayMedical intensive care unit patientsIntensive care unit patientsOlder ICU patientsDevelopment of deliriumHalf of patientsProspective cohort studyCare unit patientsMedical chart reviewNormal mental statusBaseline functional statusSeverity of illnessIntensive care unitUniversity Teaching HospitalSurrogate interviewsHospital stayBaseline characteristicsChart reviewCohort studyFrequent complicationMedical ICUOlder patients