Partial Correction of Cystic Fibrosis Defects with PLGA Nanoparticles Encapsulating Curcumin
Cartiera MS, Ferreira EC, Caputo C, Egan ME, Caplan MJ, Saltzman WM. Partial Correction of Cystic Fibrosis Defects with PLGA Nanoparticles Encapsulating Curcumin. Molecular Pharmaceutics 2009, 7: 86-93. PMID: 19886674, PMCID: PMC2815009, DOI: 10.1021/mp900138a.Peer-Reviewed Original ResearchAdministration, OralAnimalsBiological AvailabilityBiological Transport, ActiveCurcuminCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEnzyme InhibitorsHumansLactic AcidMiceMice, Inbred C57BLMice, Inbred CFTRMicroscopy, Electron, ScanningMutationNanoparticlesPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerSarcoplasmic Reticulum Calcium-Transporting ATPasesThe uptake and intracellular fate of PLGA nanoparticles in epithelial cells
Cartiera MS, Johnson KM, Rajendran V, Caplan MJ, Saltzman WM. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials 2009, 30: 2790-2798. PMID: 19232712, PMCID: PMC3195413, DOI: 10.1016/j.biomaterials.2009.01.057.Peer-Reviewed Original ResearchConceptsEpithelial cellsCell linesRenal proximal tubulesType of epitheliumParticle/cell ratiosCaco-2 cellsEpithelial cell lineIntracellular fateProximal tubulesRespiratory airwaysCell ratioImmunofluorescence techniqueOK cellsDifferent epithelial cell linesEndoplasmic reticulumConfocal analysisMajor targetConfocal microscopyExtent of uptakeCellsParticle uptakeEarly endosomesCellular uptakePLGA nanoparticlesUptake