2017
Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia
Tong M, Cheng SB, Chen Q, DeSousa J, Stone PR, James JL, Chamley LW, Sharma S. Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific Reports 2017, 7: 6694. PMID: 28751735, PMCID: PMC5532246, DOI: 10.1038/s41598-017-07017-x.Peer-Reviewed Original ResearchConceptsPreeclamptic placentasMaternal circulationNormotensive placentasPreeclampsia-like symptomsProduction of transthyretinPathogenesis of preeclampsiaNano-vesiclesPlacental extracellular vesiclesSerum levelsPreeclamptic seraMaternal organsPreeclampsiaPlacentaTotal transthyretinWestern blottingQRT-PCRExtracellular vesiclesSignificant proportionTransthyretin
2015
An analysis of the differences between early and late preeclampsia with severe hypertension
Li X, Guo P, Xue Y, Gou W, Tong M, Chen Q. An analysis of the differences between early and late preeclampsia with severe hypertension. Pregnancy Hypertension 2015, 6: 47-52. PMID: 26955772, DOI: 10.1016/j.preghy.2015.12.003.Peer-Reviewed Original ResearchConceptsLate-onset preeclampsiaSevere hypertensionLate preeclampsiaEarly preeclampsiaOnset preeclampsiaRenal functionLaboratory biomarkersEarly onsetClinical parametersSubgroups of preeclampsiaDiastolic velocity ratioUniversity Teaching HospitalBlood urea nitrogenTime of deliveryAlkaline phosphatase levelsRenal dysfunctionPerinatal mortalitySevere headacheGestational ageClinical symptomsLiver functionVision disturbancesMaternal ageTeaching hospitalHypertensionAssociations between body mass index and maternal weight gain on the delivery of LGA infants in Chinese women with gestational diabetes mellitus
Chen Q, Wei J, Tong M, Yu L, Lee A, Gao Y, Zhao M. Associations between body mass index and maternal weight gain on the delivery of LGA infants in Chinese women with gestational diabetes mellitus. Journal Of Diabetes And Its Complications 2015, 29: 1037-1041. PMID: 26376766, DOI: 10.1016/j.jdiacomp.2015.08.017.Peer-Reviewed Original ResearchMeSH KeywordsAdultBirth WeightBody Mass IndexChinaChi-Square DistributionDiabetes, GestationalFemaleFetal MacrosomiaHospitals, UniversityHumansIncidenceInfant, NewbornMaleMaternal Nutritional Physiological PhenomenaObesityOverweightPregnancyRetrospective StudiesRisk FactorsThinnessWeight GainYoung AdultConceptsMaternal body mass indexGestational diabetes mellitusBody mass indexLGA infantsMaternal weight gainExcessive weight gainPregnant womenWeight gainDiabetes mellitusMass indexNormal weight pregnant womenChinese womenIncidence of deliveryIncidence of LGAGestational age infantsOverweight pregnant womenUniversity Teaching HospitalNormal weight gainOdds of deliveryFetal complicationsGestational weeksAge infantsOdds ratioTeaching hospitalInfantsSerum uric acid may not be involved in the development of preeclampsia
Chen Q, Lau S, Tong M, Wei J, Shen F, Zhao J, Zhao M. Serum uric acid may not be involved in the development of preeclampsia. Journal Of Human Hypertension 2015, 30: 136-140. PMID: 25994995, DOI: 10.1038/jhh.2015.47.Peer-Reviewed Original ResearchConceptsDevelopment of preeclampsiaSerum levelsSecond trimesterUric acidSeverity of preeclampsiaTime of presentationHigher serum levelsSerum uric acidTime of onsetNormotensive pregnanciesThird trimesterClinical symptomsPregnant womenPreeclampsiaPrediction biomarkersEarly changesRetrospective sampleProspective sampleTrimesterWomenPresentationLess evidenceMeaningful associations