2021
Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location
Boucher G, Paradis A, Chabot-Roy G, Coderre L, Hillhouse E, Bitton A, Rosiers C, Levings M, Schumm L, Lazarev M, Brant S, Duerr R, McGovern D, Silverberg M, Cho J, Lesage S, Rioux J, Bitton A, Boucher G, Charron G, Rosiers C, Forest A, Goyette P, Ivinson S, Joseph L, Kohen R, Lachaine J, Lesage S, Levings M, Rioux J, Thompson-Legault J, Vachon L, Veilleux S, White-Guay B, Bajpai M, Birch S, Bitton A, Borowski K, Botwin G, Boucher G, Brant S, Chen W, Cho J, Cordero R, Côté-Daigneault J, Daly M, Datta L, Duerr R, Filice M, Fleshner P, Gettler K, Giri M, Goyette P, Hao K, Haritunians T, Itan Y, Johnston E, Konnikova L, Landers C, Lazarev M, Li D, McGovern D, Mengesha E, Merad M, Miladinova V, Nayeri S, Proksell S, Raquel M, Rioux J, Rymaszewski K, Sabic K, Sands B, Schumm L, Schwartz M, Silverberg M, Simpson C, Stempak J, Stevens C, Targan S, Xavier R. Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location. Inflammatory Bowel Diseases 2021, 28: 9-20. PMID: 34106269, PMCID: PMC8730700, DOI: 10.1093/ibd/izab123.Peer-Reviewed Original ResearchConceptsCrohn's diseaseDisease locationCD patientsIL-6 beingColonic Crohn's diseaseInterleukin IL-6IL-12p70Chronic inflammationColorectal diseaseIL-6Inflammatory processHealthy controlsColorectal regionIntestinal microbiotaClinical observationsEpithelial barrierImmune systemPatientsSerum analytesEndothelial systemDiseaseSerum samplesGrowth factorMultiple cell typesDigestive tractGenetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin
Mirizio E, Liu C, Yan Q, Waltermire J, Mandel R, Schollaert KL, Konnikova L, Wang X, Chen W, Torok KS. Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin. Frontiers In Pediatrics 2021, 9: 669116. PMID: 34164359, PMCID: PMC8215272, DOI: 10.3389/fped.2021.669116.Peer-Reviewed Original ResearchLocalized sclerodermaLS patientsGene signatureClinical activity parametersPediatric localized sclerodermaSignificant functional disabilityInterferon-inducible chemokinesSkin transcriptional profileIFNγ signatureProgressive diseaseFunctional disabilityInflammatory lesionsLesion biopsyParaffinized tissuesDisease progressionHealthy controlsInflammatory diseasesFibrotic pathwaysScleroderma skinCellular expressionDiseaseL subjectsGene expression profilesSkinIFNγ
2020
317 CYTOF ANALYSIS OF HUMAN COLON AND BLOOD REVEALS DISTINCT IMMUNE SIGNATURES OF ULCERATIVE COLITIS AND CROHN'S DISEASE
Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Field M, McCourt C, Toothaker J, Goldsmith J, Kean L, Shalek A, Tseng G, Konnikova L, Snapper S. 317 CYTOF ANALYSIS OF HUMAN COLON AND BLOOD REVEALS DISTINCT IMMUNE SIGNATURES OF ULCERATIVE COLITIS AND CROHN'S DISEASE. Gastroenterology 2020, 158: s-57. DOI: 10.1016/s0016-5085(20)30824-6.Peer-Reviewed Original Research
2018
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue
Konnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Mucosal Immunology 2018, 11: 1684-1693. PMID: 30111863, PMCID: PMC6512331, DOI: 10.1038/s41385-018-0047-y.Peer-Reviewed Original ResearchConceptsImmune cellsGastrointestinal tissuesMucosal immune compartmentPeripheral immune cellsMucosal immune cellsEpithelial cellsImmune compartmentImmune phenotypingTreatment responsivenessMucosal tissuesTranslational studiesDisease pathogenesisSimple storage techniquesPreservation of viabilityPathogenesisTissueBiomarker discoveryCellsDisease382 - High Dimensional Immune Phenotyping Using Mass Cytometry Reveals Unique IL1B Signatures in Peripheral Blood and GI Tissue of Ulcerative Colitis, Crohn's Disease, and IL10R Deficient Patients
Mitsialis V, Shouval D, Wall S, Snapper S, Konnikova L. 382 - High Dimensional Immune Phenotyping Using Mass Cytometry Reveals Unique IL1B Signatures in Peripheral Blood and GI Tissue of Ulcerative Colitis, Crohn's Disease, and IL10R Deficient Patients. Gastroenterology 2018, 154: s-90-s-91. DOI: 10.1016/s0016-5085(18)30750-9.Peer-Reviewed Original ResearchHuman TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy
Kotlarz D, Marquardt B, Barøy T, Lee WS, Konnikova L, Hollizeck S, Magg T, Lehle AS, Walz C, Borggraefe I, Hauck F, Bufler P, Conca R, Wall SM, Schumacher EM, Misceo D, Frengen E, Bentsen BS, Uhlig HH, Hopfner KP, Muise AM, Snapper SB, Strømme P, Klein C. Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy. Nature Genetics 2018, 50: 344-348. PMID: 29483653, PMCID: PMC6309869, DOI: 10.1038/s41588-018-0063-6.Peer-Reviewed Original ResearchConceptsInfantile inflammatory bowel diseaseInflammatory bowel diseaseTGF-β1Bowel diseaseSevere inflammatory bowel diseaseCentral nervous system diseaseNervous system diseasesRole of TGFPosterior leukoencephalopathyIntestinal immunityBrain atrophySystem diseasesTGFB1 geneBiallelic lossImpaired secretionGrowth factorTGF-β familyDiseaseTGF-β1 deficiencyNonredundant roleFunction mutationsPrototypic memberLeukoencephalopathyAtrophyEpilepsy
2017
Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea
Silverman MA, Konnikova L, Gerber JS. Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea. Gastroenterology Clinics Of North America 2017, 46: 61-76. PMID: 28164853, PMCID: PMC5314436, DOI: 10.1016/j.gtc.2016.09.010.Peer-Reviewed Original Research
2012
The Role of Nutrition in Health and Disease in Premature Infants: Current Knowledge Gaps and Defining the Research Agenda
Parker M, Konnikova L, Martin C. The Role of Nutrition in Health and Disease in Premature Infants: Current Knowledge Gaps and Defining the Research Agenda. Nutrition And Health 2012, 111-133. DOI: 10.1007/978-1-62703-224-7_8.Peer-Reviewed Original Research