2020
Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation
Toothaker JM, Presicce P, Cappelletti M, Stras SF, McCourt CC, Chougnet CA, Kallapur SG, Konnikova L. Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation. Frontiers In Immunology 2020, 11: 866. PMID: 32528468, PMCID: PMC7256198, DOI: 10.3389/fimmu.2020.00866.Peer-Reviewed Original ResearchConceptsFetal-maternal interfaceIntra-amniotic inflammationImmune cellsVillous placentaT cellsPlacental villiNatural killerTumor necrosis factor alphaAbundance of neutrophilsIA LPS exposureCD8 T cellsMemory T cellsAntigen-presenting cellsRhesus macaque modelNecrosis factor alphaDistinct immunological profilePotential therapeutic targetTNFα blockadeLPS exposureSignificant morbidityMacaque modelProinflammatory cytokinesImmunological profileFactor alphaImmunological response
2018
DOP010 Activating PIK3CD mutations cause severe intestinal lymphonodular hyperplasia and an IBD-like phenotype
Farachi S, Werner L, Konnikova L, Rea F, Vardi I, Romeo E, Barel O, De Angelis P, Dall’Oglio L, Rechavi G, Snapper S, Somech R, Weiss B, Cancrini C, Shouval D. DOP010 Activating PIK3CD mutations cause severe intestinal lymphonodular hyperplasia and an IBD-like phenotype. Journal Of Crohn's And Colitis 2018, 12: s36-s37. DOI: 10.1093/ecco-jcc/jjx180.047.Peer-Reviewed Original ResearchIBD-like phenotypeCD8 T cellsWhole-exome sequencingLymphonodular hyperplasiaPIK3CD mutationsT cellsIntestinal diffuse large B-cell lymphomaDiffuse large B-cell lymphomaExome sequencingLarge B-cell lymphomaIntestinal immune cellsEarly-onset IBDRecurrent sinopulmonary infectionsT-cell lymphopeniaB-cell lymphomaPI3K inhibitorsFirst yearNovel PI3K inhibitorsDifferent monogenic disordersGastrointestinal manifestationsMemory CD4Chronic diarrheaImmunological alterationsIntestinal inflammationIgM levels