2021
Inflammasomes and Type 1 Diabetes
Pearson JA, Wong FS, Wen L. Inflammasomes and Type 1 Diabetes. Frontiers In Immunology 2021, 12: 686956. PMID: 34177937, PMCID: PMC8219953, DOI: 10.3389/fimmu.2021.686956.Peer-Reviewed Original ResearchConceptsType 1 diabetesMultiprotein complexesEnhanced toleranceMicrobial ligandsIslet autoantibody developmentImmune responseGenetic associationMicrobial stimulationAvailable inhibitorsImportant modulatorType 1 diabetes susceptibilityPathwayDiabetes susceptibilityAutoimmune processMicrobiota compositionAutoantibody developmentMicrobiotaAnimal modelsInflammasomeActivationGenetic riskType 1DiabetesHumansRole
2006
Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility
Ge X, Piganelli J, Tse H, Bertera S, Mathews C, Trucco M, Wen L, Rudert W. Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility. Diabetes 2006, 55: 3455-3462. PMID: 17130492, DOI: 10.2337/db06-0680.Peer-Reviewed Original ResearchConceptsT cell responsesHLA moleculesCaucasian type 1 diabetic patientsCD4 T cell activityCD4 T cell linesCD4 T cell responsesType 1 diabetic patientsHLA class II allelesCertain HLA moleculesT cell activityType 1 diabetesClass II allelesT cell linesSpecific DRB1HLA-DQ8Diabetic patientsModulatory roleDisease riskDQ8Type 1DR4Diabetes susceptibilityPeptide occupancyPrimary genetic determinantGenetic determinants