2010
Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens
Burton O, Gibbs S, Miller N, Jones F, Wen L, Dunne D, Cooke A, Zaccone P. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. European Journal Of Immunology 2010, 40: 2221-2229. PMID: 20480503, DOI: 10.1002/eji.200939998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, HelminthCD4-Positive T-LymphocytesCells, CulturedFemaleForkhead Transcription FactorsGalectin 3Helminth ProteinsHost-Pathogen InteractionsImmunomodulationLectins, C-TypeMiceMice, Inbred C57BLMice, Inbred NODMice, KnockoutMinor Histocompatibility AntigensReceptors, Cell SurfaceSchistosoma mansoniToll-Like Receptor 2Transforming Growth Factor betaConceptsS. mansoni soluble egg antigenSchistosoma mansoni antigensT cellsFoxp3 expressionImportance of TLR2S. mansoni antigensSurface-bound TGFTLR2 ligand stimulationT cell secretionAccessory cell interactionsNOD miceTh2 responsesEgg antigenImmunomodulatory effectsT lymphocytesAbsence of APCC-type lectinBioactive TGFGalectin-3AntigenTGFTLR2Cell interactionsCellsLigand stimulation
2008
CD8+ T-cells and their interaction with other cells in damage to islet β-cells
Wong F, Siew L, Wen L. CD8+ T-cells and their interaction with other cells in damage to islet β-cells. Biochemical Society Transactions 2008, 36: 316-320. PMID: 18481949, DOI: 10.1042/bst0360316.Peer-Reviewed Original ResearchConceptsT cellsHuman type 1 diabetesAntigen-presenting cellsType 1 diabetesAutoimmune attackDiabetes developmentAntigenic targetsEffector stageToxic mediatorsVariety of cellsAnimal modelsTarget antigenImmune systemΒ-cellsMechanisms of damageCellsEarly stagesDamageCD8DiabetesCytokinesLymphocytesAntigen
1994
T Cell Clones Generated from Patients with Type 1 Diabetes Using Interleukin-2 Proliferate to Human Islet Antigens
Peakman M, Wen L, McNab G, Watkins P, Tan K, Vergani D. T Cell Clones Generated from Patients with Type 1 Diabetes Using Interleukin-2 Proliferate to Human Islet Antigens. Autoimmunity 1994, 17: 31-39. PMID: 8025212, DOI: 10.3109/08916939409014656.Peer-Reviewed Original ResearchMeSH KeywordsAdultAutoantigensAutoimmune DiseasesCD4 AntigensCD8 AntigensChildChild, PreschoolClone CellsDiabetes Mellitus, Type 1FemaleHumansInterleukin-2Islets of LangerhansLymphocyte ActivationMaleReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, Interleukin-2T-Lymphocyte SubsetsConceptsT cell clonesT lymphocytesIslet antigensControl subjectsAntigen specificityType 1Cell clonesT cell populationsPeripheral blood lymphocytesIL-2 receptorActivated T lymphocytesDose-dependent fashionPrediabetic periodLiver membrane preparationsPeripheral bloodAutologous APCIL-2Blood lymphocytesPatientsHuman isletsLymphocytesMembrane preparationsProliferation assaysPathogenesisAntigen
1990
T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis
Wen L, Peakman M, Lobo-Yeo A, Vergani D, Mowat A, Mieli-Vergani, McFarlane B. T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. The Lancet 1990, 336: 1527-1530. PMID: 1979365, DOI: 10.1016/0140-6736(90)93306-a.Peer-Reviewed Original ResearchConceptsAutoimmune chronic active hepatitisChronic active hepatitisActive hepatitisPeripheral bloodT lymphocytesAutologous B lymphocytesLiver membrane antigensT cell clonesAsialoglycoprotein receptorActivated T lymphocytesLiver cell membraneSpecific autoantibodiesAutoimmune attackImmune attackHepatocyte damageHepatitisB lymphocytesLymphocytesBloodLipoprotein complexAutoantibodiesPatientsCell membraneAntigenClones