2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingDiastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography
Lamy J, Xiang J, Shah N, Kwan J, Kim Y, Upadhyaya K, Reinhardt S, Meadows J, McNamara R, Baldassarre L, Peters D. Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography. Physiological Reports 2024, 12: e70078. PMID: 39604208, PMCID: PMC11602526, DOI: 10.14814/phy2.70078.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceTransthoracic echocardiographyDiastolic dysfunctionDiastolic functionDiagnostic accuracy of cardiovascular magnetic resonanceEvaluate diastolic dysfunctionCardiovascular magnetic resonance imagingLeft atrial volumeMitral annular velocityHealthy age-matched subjectsComparison to echocardiographyMitral inflow velocityEvaluate diastolic functionAge-matched subjectsPresence of DDAtrial volumeDD gradeFirst-lineAnnular velocityDiagnostic accuracyImaging modalitiesMagnetic resonanceEchocardiographyALLTransthoracicAdvanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology
Arbune A, Khattab M, Henry M, Baldassarre L. Advanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology. Current Treatment Options In Cardiovascular Medicine 2024, 27: 5. DOI: 10.1007/s11936-024-01061-3.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsBaseline risk stratificationCardiac computed tomographyCardiac magnetic resonanceAdvanced cardiac imaging modalitiesPositron emission tomographyCardiac imaging modalitiesCoronary artery calciumRisk stratificationCardio-oncologyImaging modalitiesCardiac massEvaluate immune checkpoint inhibitorsImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitor therapyAdvanced cardiac imaging techniquesCardiac positron emission tomographyDiagnosis of cardiotoxicityNoninvasive diagnostic testCardiac imaging techniquesRisk stratification toolCardio-oncology patientsAdvanced imaging modalitiesCoronary flow reserveImaging techniquesRetraction notice to Gedatolisib Associated Acute Myocarditis in a Patient With Breast Adenocarcinoma J Am Coll Cardiol. 2024;83(13 Suppl):3575.
Shen M, Khattab M, Akintoye E, Baldassarre L, Kwan J. Retraction notice to Gedatolisib Associated Acute Myocarditis in a Patient With Breast Adenocarcinoma J Am Coll Cardiol. 2024;83(13 Suppl):3575. Journal Of The American College Of Cardiology 2024, 84: 1683. DOI: 10.1016/j.jacc.2024.09.017.Peer-Reviewed Original ResearchArtificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images.
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images. Circulation Cardiovascular Quality And Outcomes 2024 PMID: 39221857, DOI: 10.1161/circoutcomes.124.011504.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular systolic dysfunctionCardiac dysfunctionBreast cancerNon-Hodgkin lymphoma therapyNon-Hodgkin's lymphomaVentricular systolic dysfunctionAssociated with worse global longitudinal strainRisk stratification strategiesHigh-risk groupMonths post-treatmentPost hoc analysisElectrocardiographic (ECGTrastuzumab exposureLymphoma therapySystolic dysfunctionAI-ECGBefore treatmentRisk biomarkersLongitudinal strainLow riskStratification strategiesHigher incidencePositive screenArtificial Intelligence and Machine Learning for Cardiovascular Computed Tomography (CCT): A White Paper of the Society of Cardiovascular Computed Tomography (SCCT)
Williams M, Weir-McCall J, Baldassarre L, De Cecco C, Choi A, Dey D, Dweck M, Isgum I, Kolossvary M, Leipsic J, Lin A, Lu M, Motwani M, Nieman K, Shaw L, van Assen M, Nicol E. Artificial Intelligence and Machine Learning for Cardiovascular Computed Tomography (CCT): A White Paper of the Society of Cardiovascular Computed Tomography (SCCT). Journal Of Cardiovascular Computed Tomography 2024, 18: 519-532. PMID: 39214777, DOI: 10.1016/j.jcct.2024.08.003.Peer-Reviewed Original ResearchRemoved: “Kiosk 8Q-FA-03—Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma” [Journal of Cardiovascular Magnetic Resonance 26 (2024) 100856]
Khattab M, Kwan J, Alkhatib D, Shen M, Desai S, Akintoye E, Huber S, Baldassarre L. Removed: “Kiosk 8Q-FA-03—Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma” [Journal of Cardiovascular Magnetic Resonance 26 (2024) 100856]. Journal Of Cardiovascular Magnetic Resonance 2024, 101084. PMID: 39181776, DOI: 10.1016/j.jocmr.2024.101084.Peer-Reviewed Original ResearchAdverse social determinants of health elevate uncontrolled hypertension risk: a cardio-oncology prospective cohort study
Nain P, Stabellini N, Makram O, Rast J, Yerraguntla S, Gopu G, Bhave A, Seth L, Patel V, Jiang S, Malik S, Shetewi A, Montero A, Cullen J, Agarwal N, Wang X, Ky B, Baldassarre L, Weintraub N, Harris R, Guha A. Adverse social determinants of health elevate uncontrolled hypertension risk: a cardio-oncology prospective cohort study. JNCI Cancer Spectrum 2024, 8: pkae064. PMID: 39115393, PMCID: PMC11368120, DOI: 10.1093/jncics/pkae064.Peer-Reviewed Original ResearchSocial determinants of healthSocial determinants of health scoreSocial determinantsAdverse SDHImpact of social determinants of healthUncontrolled hypertensionAdverse social determinantsDeterminants of healthRisk of uncontrolled hypertensionProspective cohort studyCardio-oncology clinicCancer patientsBlood pressure readingsHypertension riskHypertension controlCohort studySocial isolationUrban residentsClinic blood pressure readingsControlled hypertensionIncreased riskProspective study patientsCox regressionCardio-oncologyHealthKiosk 8Q-FA-03 Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma
Khattab M, Kwan J, Alkhatib D, Shen M, Desai S, Akintoye E, Huber S, Baldassarre L. Kiosk 8Q-FA-03 Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100856. PMID: 39155091, DOI: 10.1016/j.jocmr.2024.100856.Peer-Reviewed Original ResearchGEDATOLISIB ASSOCIATED ACUTE MYOCARDITIS IN A PATIENT WITH BREAST CANCER
Shen M, Khattab M, Akintoye E, Baldassarre L, Kwan J. GEDATOLISIB ASSOCIATED ACUTE MYOCARDITIS IN A PATIENT WITH BREAST CANCER. Journal Of The American College Of Cardiology 2024, 83: 3575. PMID: 39327001, DOI: 10.1016/s0735-1097(24)05565-7.Peer-Reviewed Original ResearchMultimodality Cardiac Imaging and the Imaging Workforce in the United States: Diversity, Disparities, and Future Directions
Bullock-Palmer R, Rosario K, Douglas P, Hahn R, Lang R, Chareonthaitawee P, Srichai M, Ordovas K, Baldassarre L, Burroughs M, Henderson C, Woodard P, Pressoir K, Swaminathan M, Blankstein R, Daubert M. Multimodality Cardiac Imaging and the Imaging Workforce in the United States: Diversity, Disparities, and Future Directions. Circulation Cardiovascular Imaging 2024, 17: e016409. PMID: 38377238, DOI: 10.1161/circimaging.123.016409.Peer-Reviewed Original ResearchKiosk 5R-TA-01 Left Atrial Evaluation in Immune Check Point Inhibitor Myocarditis Using Cardiac Magnetic Resonance Imaging and Correlations with Cardiovascular Outcomes
Jeyashanmugaraja G, Kwan J, Shah N, Lamy J, Khattab M, Chehayeb R, Guajardo A, Lin D, Christofides A, Alkhatib D, Martinez C, Im Y, Salem J, Redheuil A, Peters D, Baldassarre L. Kiosk 5R-TA-01 Left Atrial Evaluation in Immune Check Point Inhibitor Myocarditis Using Cardiac Magnetic Resonance Imaging and Correlations with Cardiovascular Outcomes. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100677. DOI: 10.1016/j.jocmr.2024.100677.Peer-Reviewed Original ResearchKiosk 5R-TB-01 Prospective Evaluation of Immune Checkpoint Inhibitor Myocarditis with Serial Quantitative Cardiovascular Magnetic Resonance and Correlations with Cardiovascular Outcomes
Khattab M, Kwan J, Chehayeb R, Guajardo A, Lin D, Christophides A, Alkhatib D, Martinez C, Shah N, Im Y, Jeyashanmugaraja G, Ragheb E, Higgins A, Redheiul A, Salem J, Peters D, Mohjibian H, Baldassarre L. Kiosk 5R-TB-01 Prospective Evaluation of Immune Checkpoint Inhibitor Myocarditis with Serial Quantitative Cardiovascular Magnetic Resonance and Correlations with Cardiovascular Outcomes. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100686. DOI: 10.1016/j.jocmr.2024.100686.Peer-Reviewed Original ResearchKiosk 5R-TA-04 Comprehensive Characterization of Cardiac, Skeletal and Diaphragmatic Myotoxicity Using CMR in Patients with Immune Checkpoint Inhibitor Therapy and Relation to Outcomes
Charpentier E, boussouar S, Bretagne M, Bouazizi K, Kachenoura N, Nguyen L, Pasi N, Edhery S, allenbach Y, Similowski T, Kerneis M, Baldassarre L, Salem J, Redheuil A. Kiosk 5R-TA-04 Comprehensive Characterization of Cardiac, Skeletal and Diaphragmatic Myotoxicity Using CMR in Patients with Immune Checkpoint Inhibitor Therapy and Relation to Outcomes. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100680. DOI: 10.1016/j.jocmr.2024.100680.Peer-Reviewed Original Research
2023
SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction
Avula V, Sharma G, Kosiborod M, Vaduganathan M, Neilan T, Lopez T, Dent S, Baldassarre L, Scherrer-Crosbie M, Barac A, Liu J, Deswal A, Khadke S, Yang E, Ky B, Lenihan D, Nohria A, Dani S, Ganatra S. SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction. JACC Heart Failure 2023, 12: 67-78. PMID: 37897456, DOI: 10.1016/j.jchf.2023.08.026.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionSGLT2 inhibitor useGuideline-directed medical therapyHeart failureInhibitor useSGLT2 inhibitorsMedical therapyCardiac dysfunctionAntineoplastic therapyAtrial fibrillation/flutterType 2 diabetes mellitusAcute HF exacerbationCox proportional HRsAcute kidney injuryRenal replacement therapyRetrospective cohort analysisIschemic heart diseaseRisk of cardiomyopathyAggregate patient dataTriNetX Research NetworkProportional HRsCause hospitalizationCause mortalityHF exacerbationKidney injuryAtrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation
Lamy J, Taoutel R, Chamoun R, Akar J, Niederer S, Mojibian H, Huber S, Baldassarre L, Meadows J, Peters D. Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation. The International Journal Of Cardiovascular Imaging 2023, 40: 107-117. PMID: 37857929, PMCID: PMC11378145, DOI: 10.1007/s10554-023-02968-x.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLA reservoir strainLeft atrial pressureLA volumeReservoir strainLA fibrosisLA strainStiffness indexLA late gadolinium enhancementAtrial stiffness indexMaximal LA volumeAtrial fibrillation cohortLA minimum volumeAtrial tissue fibrosisMaximum LA volumeCardiac MR examsAtrial stiffnessAtrial strainAF ablationAtrial pressureAF cohortAtrial fibrillationAtrial fibrosisPatient subgroupsLGE volumeMultimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report
Shah T, Shah N, Baldassarre L, Freed L, Mojibian H, Shah S. Multimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101125. PMID: 39129904, PMCID: PMC11308843, DOI: 10.1016/j.jscai.2023.101125.Peer-Reviewed Case Reports and Technical NotesScientific document development standards for the society of cardiovascular computed tomography (SCCT): A statement from the SCCT Guidelines Committee
Baldassarre L, Koweek L, Andreini D, Branch K, Brennaman D, Budde R, De La O S, Fairbairn T, Hedgire S, Weir-McCall J, Woodard P, Wong D, Chen M, Committee S. Scientific document development standards for the society of cardiovascular computed tomography (SCCT): A statement from the SCCT Guidelines Committee. Journal Of Cardiovascular Computed Tomography 2023, 17: 459-464. PMID: 37429770, DOI: 10.1016/j.jcct.2023.06.006.Peer-Reviewed Original ResearchQuantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients
Kwan J, Arbune A, Henry M, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader A, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre L. Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients. PLOS ONE 2023, 18: e0286364. PMID: 37252927, PMCID: PMC10228774, DOI: 10.1371/journal.pone.0286364.Peer-Reviewed Original ResearchConceptsBreast cancer patientsSystolic heart failureCardiovascular outcomesCancer patientsHeart failureValvular diseaseStrain abnormalitiesLeft ventricular ejection fraction reductionCancer treatment-related cardiotoxicityCardiovascular magnetic resonance findingsVentricular ejection fraction reductionYale-New Haven HospitalEjection fraction reductionTreatment-related cardiotoxicityAdverse cardiovascular outcomesClinical risk factorsNormal LV functionGlobal longitudinal strainIschemic heart diseaseMagnetic resonance findingsRisk regression modelsNew Haven HospitalSubclinical cardiotoxicityDiastolic dysfunctionStatin useAdvances in Coronary Computed Tomographic Angiographic Imaging of Atherosclerosis for Risk Stratification and Preventive Care
Bienstock S, Lin F, Blankstein R, Leipsic J, Cardoso R, Ahmadi A, Gelijns A, Patel K, Baldassarre L, Hadley M, LaRocca G, Sanz J, Narula J, Chandrashekhar Y, Shaw L, Fuster V. Advances in Coronary Computed Tomographic Angiographic Imaging of Atherosclerosis for Risk Stratification and Preventive Care. JACC Cardiovascular Imaging 2023, 16: 1099-1115. PMID: 37178070, DOI: 10.1016/j.jcmg.2023.02.002.Peer-Reviewed Original ResearchConceptsCoronary Computed Tomography AngiographyCoronary artery diseaseAtherosclerotic plaquesArtery diseaseRisk stratificationPreventive carePlaque volumeHigh-risk plaque featuresNonobstructive coronary artery diseaseCoronary CTAMeasurements of atherosclerosisEffective risk stratificationHigh-risk patientsTotal plaque volumeComputed tomography angiographyPatient-specific factorsCoronary artery dimensionsIntravascular ultrasound measurementsHealth care systemCoronary dominanceCardiovascular preventionPatient subsetsPlaque featuresArtery sizeTomography angiography