2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imaging
2023
SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction
Avula V, Sharma G, Kosiborod M, Vaduganathan M, Neilan T, Lopez T, Dent S, Baldassarre L, Scherrer-Crosbie M, Barac A, Liu J, Deswal A, Khadke S, Yang E, Ky B, Lenihan D, Nohria A, Dani S, Ganatra S. SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction. JACC Heart Failure 2023, 12: 67-78. PMID: 37897456, DOI: 10.1016/j.jchf.2023.08.026.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionSGLT2 inhibitor useGuideline-directed medical therapyHeart failureInhibitor useSGLT2 inhibitorsMedical therapyCardiac dysfunctionAntineoplastic therapyAtrial fibrillation/flutterType 2 diabetes mellitusAcute HF exacerbationCox proportional HRsAcute kidney injuryRenal replacement therapyRetrospective cohort analysisIschemic heart diseaseRisk of cardiomyopathyAggregate patient dataTriNetX Research NetworkProportional HRsCause hospitalizationCause mortalityHF exacerbationKidney injuryImpaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis
Feher A, Miller E, Peters D, Mojibian H, Sinusas A, Hinchcliff M, Baldassarre L. Impaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis. Rheumatology International 2023, 43: 849-858. PMID: 36894756, DOI: 10.1007/s00296-023-05294-6.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLV-GLSSystemic sclerosisWorse survivalClinical indicationsImpaired left ventricular global longitudinal strainLeft ventricular global longitudinal strainPresence of LGECMR strainLV cardiac indexWorse LV-GLSLV ejection fractionCox regression analysisGlobal longitudinal strainLV cardiac outputGlobal radialCardiac indexOverall survivalRetrospective cohortEjection fractionPrognostic valueAdverse outcomesCardiac outputGadolinium enhancementRV strainMyocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement
Vidula M, Rajewska-Tabor J, Cao J, Kang Y, Craft J, Mei W, Chandrasekaran P, Clark D, Poenar A, Gorecka M, Malahfji M, Cowan E, Kwan J, Reinhardt S, Al-Tabatabaee S, Doeblin P, Villa A, Karagodin I, Alvi N, Christia P, Spetko N, Cassar M, Park C, Nambiar L, Turgut A, Azad M, Lambers M, Wong T, Salerno M, Kim J, Elliott M, Raman B, Neubauer S, Tsao C, LaRocca G, Patel A, Chiribiri A, Kelle S, Baldassarre L, Shah D, Hughes S, Tong M, Pyda M, Simonetti O, Plein S, Han Y. Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement. JACC Cardiovascular Imaging 2023, 16: 609-624. PMID: 36752429, PMCID: PMC9833283, DOI: 10.1016/j.jcmg.2022.10.021.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceNatriuretic peptide elevationMyocardial injuryIschemic patternTroponin elevationCardiac involvementChest discomfortInjury patternsCOVID-19Cardiac biomarker elevationCOVID-19 infectionAcute myocarditisAcute ischemicBiomarker elevationCardiac symptomsClinical suspicionCoronary diseaseMulticenter cohortAbnormal electrocardiogramMulticenter studyRetrospective studyECG abnormalitiesUnivariate analysisPatientsMultivariate analysis
2022
Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry
Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, contributors I, Aghel N, Alexandre J, Aonuma K, Asnani A, Behling J, Bilen M, Bottinor W, Cariou E, Chahine J, Chan W, Chauhan A, Cohen M, Crusz S, Fernando S, Florido R, Frigeri M, Fukushima S, Gaughan E, Geisler B, Gilstrap L, Grohe C, Guha A, Habib M, Haegler-Laube E, Haydon A, Hayek S, Hughes A, Imai R, Katsume Y, Kimura H, Lin L, Lenneman C, Leong D, Makker V, Martinez-Calle N, Moey M, Mohri M, Morimoto R, Moritoki Y, Narezkina A, Nicol M, Nooka A, Orimoloye O, Patel M, Perl M, Piriou N, Raikhelkar J, Raza Y, Rao A, Reddy S, Seki N, Stangl K, Stewart A, Stringer B, Tamarappoo B, Tamura Y, Thuny F, Tierney S, Tresorier R, Ullah W, Von Hunolstein J, Warner E, Weppler A. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. European Journal Of Cancer 2022, 177: 197-205. PMID: 36030143, PMCID: PMC10165738, DOI: 10.1016/j.ejca.2022.07.018.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseHumansImmune Checkpoint InhibitorsMyocarditisPrognosisRegistriesRetrospective StudiesRisk FactorsConceptsCoronary artery diseaseImmune checkpoint blockersCoronary revascularizationArtery diseaseCAD groupInternational registryPrompt clinical diagnosisAcute coronary syndromeCoronary artery stenosisAdjustment of ageCause deathCoronary syndromeIndex hospitalisationSteroid administrationCheckpoint blockersCoronary angiographyArtery stenosisCoronary angiogramPoor outcomeSevere presentationRevascularizationPatientsCardiac pathologyClinical diagnosisMyocarditis
2019
Valvular imaging in the era of feature‐tracking: A slice‐following cardiac MR sequence to measure mitral flow
Seemann F, Heiberg E, Carlsson M, Gonzales RA, Baldassarre LA, Qiu M, Peters DC. Valvular imaging in the era of feature‐tracking: A slice‐following cardiac MR sequence to measure mitral flow. Journal Of Magnetic Resonance Imaging 2019, 51: 1412-1421. PMID: 31654470, PMCID: PMC7217167, DOI: 10.1002/jmri.26971.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityHumansMagnetic Resonance ImagingMitral Valve InsufficiencyProspective StudiesReproducibility of ResultsRetrospective StudiesConceptsMitral valve dysfunctionAortic stroke volumeStroke volumeHealthy subjectsValve dysfunctionMitral flowMitral valveMitral flow patternTransmitral blood flowMitral stroke volumeStage 2 J. MagnDiastolic functionMitral regurgitationTransmitral flowCine phase contrastDysfunction patientsClinical examinationBland-Altman analysisPhase-contrast sequenceBlood flowJ. MagnImportant clinical examinationTechnical efficacyPatientsT-testLeft atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy
Latif SR, Nguyen VQ, Peters DC, Soufer A, Henry ML, Grunseich K, Testani J, Hur DJ, Huber S, Mojibian H, Dicks D, Sinusas AJ, Meadows JL, Papoutsidakis N, Jacoby D, Baldassarre LA. Left atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy. The International Journal Of Cardiovascular Imaging 2019, 35: 1309-1318. PMID: 30790116, DOI: 10.1007/s10554-019-01551-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAtrial Function, LeftAtrial RemodelingCardiomyopathy, HypertrophicContrast MediaFemaleFibrosisHeart AtriaHeart VentriclesHumansHypertrophy, Left VentricularMagnetic Resonance Imaging, CineMaleMiddle AgedOrganometallic CompoundsPredictive Value of TestsRetrospective StudiesVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsLA fibrosisLV-LGEHypertrophic cardiomyopathyLA-LGELV fibrosisLV parametersLV end-diastolic volumeSetting of HCMAldosterone system inhibitionLate gadolinium enhancement (LGE) sequencesLV global strainLeft ventricular massEnd-diastolic volumeLeft atrial fibrosisMaximum wall thicknessFibrosis correlatesRenin-AngiotensinVentricular strainMedication usageAtrial fibrosisLV remodelingVentricular massLV massSystem inhibitionDiastolic volumePrognostic and functional implications of left atrial late gadolinium enhancement cardiovascular magnetic resonance
Quail M, Grunseich K, Baldassarre LA, Mojibian H, Marieb MA, Cornfeld D, Soufer A, Sinusas AJ, Peters DC. Prognostic and functional implications of left atrial late gadolinium enhancement cardiovascular magnetic resonance. Journal Of Cardiovascular Magnetic Resonance 2019, 21: 2. PMID: 30602395, PMCID: PMC6317232, DOI: 10.1186/s12968-018-0514-3.Peer-Reviewed Original ResearchConceptsLA late gadolinium enhancementNew-onset atrial arrhythmiasLate gadolinium enhancementAtrial arrhythmiasAtrial late gadolinium enhancementLA functionAtrial fibrillationGadolinium enhancementCardiovascular magnetic resonance imagingNew atrial arrhythmiasPoor procedural outcomesLV diastolic functionLA ejection fractionVentricular mechanical functionCardiovascular magnetic resonanceMagnetic resonance imagingSeptal eDiastolic functionEjection fractionHazard ratioLA volumeProcedural outcomesPrognostic biomarkerCardiac diseasePrior history