2018
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study
Liu L, Urch B, Szyszkowicz M, Evans G, Speck M, Van Huang A, Leingartner K, Shutt RH, Pelletier G, Gold DR, Brook JR, Godri Pollitt K, Silverman FS. Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environment International 2018, 121: 1331-1340. PMID: 30420132, PMCID: PMC6396878, DOI: 10.1016/j.envint.2018.10.055.Peer-Reviewed Original ResearchConceptsUbiquitin C-terminal hydrolase L1Vascular endothelium growth factorBiomarker levelsPost exposureSystemic inflammationOxidative stressNeural biomarkersS100 calcium-binding protein BCalcium-binding protein BNeural functionHealthy non-smoking volunteersConcentrated ambient PMAssessment of biomarkersNon-smoking volunteersStress marker cortisolAmbient PMUrinary malondialdehydeUrinary biomarkersUrinary cortisolInterleukin-6Mixed regression modelsVanillylmandelic acidInflammationMean concentrationGrowth factorFine Particulate Air Pollution and Adverse Birth Outcomes: Effect Modification by Regional Nonvolatile Oxidative Potential
Lavigne É, Burnett RT, Stieb DM, Evans GJ, Godri Pollitt KJ, Chen H, van Rijswijk D, Weichenthal S. Fine Particulate Air Pollution and Adverse Birth Outcomes: Effect Modification by Regional Nonvolatile Oxidative Potential. Environmental Health Perspectives 2018, 126: 077012. PMID: 30073952, PMCID: PMC6108848, DOI: 10.1289/ehp2535.Peer-Reviewed Original ResearchConceptsTerm low birth weightLow birth weightAdverse birth outcomesPreterm birthBirth outcomesHighest quartileBirth weightEffect modificationFirst trimester PMRetrospective cohort studyTerm birth weightFine particulate air pollutionPossible effect modificationDays of deliveryFine particulate matter air pollutionParticulate matter air pollutionMatter air pollutionEffects of PMEstimate of effectParticulate air pollutionPreterm deliveryCohort studySingleton birthsPrenatal exposureImpact of PM
2016
Fine Particulate Matter and Emergency Room Visits for Respiratory Illness. Effect Modification by Oxidative Potential
Weichenthal SA, Lavigne E, Evans GJ, Pollitt K, Burnett RT. Fine Particulate Matter and Emergency Room Visits for Respiratory Illness. Effect Modification by Oxidative Potential. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 577-86. PMID: 26963193, DOI: 10.1164/rccm.201512-2434oc.Peer-Reviewed Original ResearchConceptsEmergency room visitsAcute respiratory morbidityRespiratory illnessRoom visitsImpact of PM2.5Respiratory morbidityChronic obstructive pulmonary diseaseAcute respiratory illnessObstructive pulmonary diseaseFine particulate air pollutionCases of asthmaConditional logistic regressionCase-crossover studyParticulate air pollutionRespiratory outcomesPulmonary diseaseEmergency roomEffect modificationRespiratory tractDaily air pollution dataInterquartile changeTime-varying covariatesOxidative burdenIllnessLogistic regression
2015
Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC)
Weichenthal S, Crouse DL, Pinault L, Godri-Pollitt K, Lavigne E, Evans G, van Donkelaar A, Martin RV, Burnett RT. Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC). Environmental Research 2015, 146: 92-99. PMID: 26745732, DOI: 10.1016/j.envres.2015.12.013.Peer-Reviewed Original ResearchConceptsCause-specific mortalityFine particulate air pollutionOxidative burdenParticulate air pollutionHazard ratioLung cancer hazard ratiosLong-term mortality riskCox proportional hazards modelCanadian Census HealthCancer hazard ratioLung cancer mortalityRisk of mortalityProportional hazards modelRespiratory tract lining fluidCanadian Long Form CensusEnvironment CohortSynthetic respiratory tract lining fluidCancer mortalityLung cancerLining fluidMortality riskHazards modelIndividual-level covariatesInterquartile changeLong-form census