2020
Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models
Ganguly K, Nordström A, Thimraj TA, Rahman M, Ramström M, Sompa SI, Lin EZ, O’Brien F, Koelmel J, Ernstgård L, Johanson G, Pollitt KJG, Palmberg L, Upadhyay S. Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models. Scientific Reports 2020, 10: 20460. PMID: 33235237, PMCID: PMC7686373, DOI: 10.1038/s41598-020-77452-w.Peer-Reviewed Original ResearchConceptsElectronic cigarettesSafety profilingInjury/repairMucosa modelEpithelial barrier functionExpression of markersNicotine contentAnti-microbial defenseTissue injury/repairNicotine presenceHuman bronchialFlavoring agentBarrier functionLung modelOxidative stressEvidence-based policy recommendationsSignificant differencesRespiratory treeMulti-disciplinary approachLimited toxicity dataMultiple factorsAir-liquid interfaceSpecific roleToxicityCytotoxic compounds
2019
Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives
Hung S, Mohan A, Reckhow DA, Godri Pollitt KJ. Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives. Chemosphere 2019, 234: 902-908. PMID: 31519098, DOI: 10.1016/j.chemosphere.2019.06.086.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesNormal human colon cellsHuman liver cancer cellsConcentration-dependent decreaseLiver cancer cellsIntracellular reactive oxygen speciesHuman colon cellsStudy designCell culture mediumCancer cellsColon cellsROS productionCulture mediumGreater cytotoxicityCell linesAcute cytotoxicityCell viabilityToxicological profileToxicological studiesCytotoxicityToxicityEnhanced toxicityOxygen speciesCell mediumPotential underestimation