2004
Burn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model
Davis KA, Santaniello JM, He LK, Muthu K, Sen S, Jones SB, Gamelli RL, Shankar R. Burn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model. Journal Of Trauma And Acute Care Surgery 2004, 56: 272-278. PMID: 14960967, DOI: 10.1097/01.ta.0000108995.64133.90.Peer-Reviewed Original ResearchConceptsColony-stimulating factorPulmonary sepsisCytokine tumor necrosisSystemic sepsisInterleukin-6Tumor necrosisProinflammatory cytokine tumor necrosisInflammatory cytokine tumor necrosisAlveolar macrophage releaseBurn/traumaDorsal scald burnGram stainMultiple organ failureDevelopment of pneumoniaGranulocyte-macrophage (GM) CSFFemoral bone marrow cellsEnd-organ responseIsolated alveolar macrophagesPositive tissue culturesPseudomonas aeruginosaWhole lung tissueMale B6D2F1 miceTissue Gram stainMacrophage colony-stimulating factorBone marrow cells
2001
COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA. Shock 2001, 15: 479-484. PMID: 11386622, DOI: 10.1097/00024382-200115060-00012.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal AbscessAbdominal InjuriesAminoimidazole CarboxamideAnimalsAnti-Inflammatory AgentsBlood PressureCapillariesDisease Models, AnimalHemodynamicsInflammationLactatesLungLung InjuryNeutrophilsPulmonary AlveoliPulmonary ArteryResuscitationRibonucleotidesShock, HemorrhagicSteroidsSwineConceptsSecondary lung injuryAbdominal traumaG-CSFPMN activationLung injuryHemorrhagic shockAnalysis of BALLate septic complicationsLavage leukocyte countPulmonary reperfusion injurySecondary pulmonary changesAnti-inflammatory drugsAnti-inflammatory metabolitesWhite blood cellsNeutrophil sequestrationPulmonary contusionSeptic complicationsPMN infiltrationPulmonary changesReperfusion injurySecondary injuryResuscitation strategiesShed bloodCombination therapyEndogenous adenosine
2000
Endogenous Adenosine and Secondary Injury after Chest Trauma
Davis K, Fabian T, Ragsdale D, Trenthem L, Proctor A. Endogenous Adenosine and Secondary Injury after Chest Trauma. Journal Of Trauma And Acute Care Surgery 2000, 49: 892-898. PMID: 11086782, DOI: 10.1097/00005373-200011000-00017.Peer-Reviewed Original ResearchConceptsBlunt chest traumaBlunt chest injuryChest traumaAdenosine-regulating agentSecondary injuryBAL proteinChest injuriesEndogenous adenosineLung myeloperoxidase levelsTime of resuscitationAnti-inflammatory actionProgressive inflammatory responseAction of adenosineAlveolar-capillary membraneWet-dry ratioBAL WBCPulmonary contusionContralateral lungMyeloperoxidase levelsSystemic hemodynamicsUninjured lungsLung edemaRight chestMongrel pigsPathophysiologic changes