2021
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
Ovadia C, Sajous J, Seed PT, Patel K, Williamson NJ, Attilakos G, Azzaroli F, Bacq Y, Batsry L, Broom K, Brun-Furrer R, Bull L, Chambers J, Cui Y, Ding M, Dixon PH, Estiú MC, Gardiner FW, Geenes V, Grymowicz M, Günaydin B, Hague WM, Haslinger C, Hu Y, Indraccolo U, Juusela A, Kane SC, Kebapcilar A, Kebapcilar L, Kohari K, Kondrackienė J, Koster MPH, Lee RH, Liu X, Locatelli A, Macias RIR, Madazli R, Majewska A, Maksym K, Marathe JA, Morton A, Oudijk MA, Öztekin D, Peek MJ, Shennan AH, Tribe RM, Tripodi V, Özterlemez N, Vasavan T, Wong LFA, Yinon Y, Zhang Q, Zloto K, Marschall HU, Thornton J, Chappell LC, Williamson C. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology 2021, 6: 547-558. PMID: 33915090, PMCID: PMC8192305, DOI: 10.1016/s2468-1253(21)00074-1.Peer-Reviewed Original ResearchConceptsUrsodeoxycholic acid treatmentPrevalence of stillbirthIndividual participant dataIntrahepatic cholestasisBile acid concentrationsUrsodeoxycholic acidComposite outcomeParticipant dataPerinatal outcomesPreterm birthSystematic reviewIndividual participant data analysisLow overall event rateComposite of stillbirthMain secondary outcomesUnpublished cohort studiesAdverse perinatal outcomesMore study participantsOverall event rateTwo-arm studyWeb of ScienceCohort studySecondary outcomesSingleton pregnanciesPrimary outcome
2017
Outcome After Implementation of a Modern Management Strategy for Intrahepatic Cholestasis of Pregnancy
Kohari K, Carroll R, Capogna S, Ditchik A, Fox N, Ferrara L. Outcome After Implementation of a Modern Management Strategy for Intrahepatic Cholestasis of Pregnancy. Obstetrical & Gynecological Survey 2017, 72: 521-522. DOI: 10.1097/01.ogx.0000524473.91161.4d.Peer-Reviewed Original Research
2016
Mitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy
Mella MT, Kohari K, Jones R, Peña J, Ferrara L, Stone J, Lambertini L. Mitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy. Placenta 2016, 45: 16-23. PMID: 27577705, DOI: 10.1016/j.placenta.2016.07.002.Peer-Reviewed Original ResearchConceptsOxidative stress statusIntrahepatic cholestasisHepatic bile acid accumulationHigher maternal serum levelsMaternal serum levelsSpontaneous preterm birthNon-pregnant stateBile acid levelsBile acid concentrationsBile acid accumulationStress statusPathophysiology of ICPOxidative stress ratePreterm birthClinical courseFetal demiseSerum levelsFetal effectsPregnant womenHigh oxidative stressReal-time PCRLong-term effectsMitochondrial activityPlacenta samplesBile acids