2008
Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells
von Wichert G, Edenfeld T, von Blume J, Krisp H, Krndija D, Schmid H, Oswald F, Lother U, Walther P, Adler G, Seufferlein T. Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells. Cellular Signalling 2008, 20: 925-934. PMID: 18262756, DOI: 10.1016/j.cellsig.2008.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceBiological Transport, ActiveCell Line, TumorChromogranin AGolgi ApparatusHumansMolecular Sequence DataNeuroendocrine TumorsProtein Kinase D2Protein Kinase InhibitorsProtein KinasesRNA, Small InterferingSecretory VesiclesSignal TransductionTrans-Golgi NetworkConceptsTrans-Golgi networkNeuroendocrine tumor cellsGolgi networkFunctional neuroendocrine tumorsProtein kinase D (PKD) familyGolgi apparatusProtein kinase D2Secretory granulesTumor cellsSerine-threonine kinaseHormone secretionNeuroendocrine tumorsChromogranin APerinuclear retentionThreonine kinaseSecretory vesiclesPrecise regulationAutonomous hormone secretionD family
2006
New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases
Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R. New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases. Molecular And Cellular Biology 2006, 26: 7086-7102. PMID: 16980613, PMCID: PMC1592903, DOI: 10.1128/mcb.00231-06.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsActive Transport, Cell NucleusAmino Acid SequenceAnimalsBinding SitesCell NucleusCells, CulturedChlorocebus aethiopsCOS CellsCytoplasmHeLa CellsHistone DeacetylasesHumansMolecular Sequence DataPhosphorylationPhosphoserineProtein Serine-Threonine KinasesProtein TransportSubstrate SpecificityConceptsMicrotubule affinity-regulating kinaseClass IIa HDACsN-terminal serine residueClass IIa histoneIIa HDACsC-TAK1IIa histoneSerine residuesMajor developmental programsMARK/ParVariety of kinasesHierarchical phosphorylationRepressive activityNuclear exportRepressive functionDevelopmental programSubcellular localizationNuclear exclusionConstitutive phosphorylationSophisticated regulationPhosphorylationKinaseSpecific signalsHDACsHistones